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Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio

Pseudovibrio is a marine bacterial genus members of which are predominantly isolated from sessile marine animals, and particularly sponges. It has been hypothesized that Pseudovibrio spp. form mutualistic relationships with their hosts. Here, we studied Pseudovibrio phylogeny and genetic adaptations...

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Main Authors: Versluis, Dennis, Nijsse, Bart, Naim, Mohd Azrul, Koehorst, Jasper J., Wiese, Jutta, Imhoff, Johannes F, Schaap, Peter J, van Passel, Mark W J, Smidt, Hauke, Sipkema, Detmer
Format: Article
Language:English
Published: Oxford University Press 2018
Subjects:
QR Microbiology
Online Access:http://irep.iium.edu.my/61482/3/7319_Comparative%20genomics%20highlights%20symbiotic%20capacities%20and%20high%20metabolic%20flexibility%20of%20the%20marine%20genus%20pseudovibrio.pdf
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spelling my.iium.irep.614822018-01-17T10:24:13Z http://irep.iium.edu.my/61482/ Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio Versluis, Dennis Nijsse, Bart Naim, Mohd Azrul Koehorst, Jasper J. Wiese, Jutta Imhoff, Johannes F Schaap, Peter J van Passel, Mark W J Smidt, Hauke Sipkema, Detmer QR Microbiology Pseudovibrio is a marine bacterial genus members of which are predominantly isolated from sessile marine animals, and particularly sponges. It has been hypothesized that Pseudovibrio spp. form mutualistic relationships with their hosts. Here, we studied Pseudovibrio phylogeny and genetic adaptations that may play a role in host colonization by comparative genomics of 31 Pseudovibrio strains, including 25 sponge isolates. All genomes were highly similar in terms of encoded core metabolic pathways, albeit with substantial differences in overall gene content. Based on gene composition, Pseudovibrio spp. clustered by geographic region, indicating geographic speciation. Furthermore, the fact that isolates from the Mediterranean Sea clustered by sponge species suggested host-specific adaptation or colonization. Genome analyses suggest that Pseudovibrio hongkongensis UST20140214-015BT is only distantly related to other Pseudovibrio spp., thereby challenging its status as typical Pseudovibrio member. All Pseudovibrio genomes were found to encode numerous proteins with SEL1 and tetratricopeptide repeats, which have been suggested to play a role in host colonization. For evasion of the host immune system, Pseudovibrio spp. may depend on type III, IV, and VI secretion systems that can inject effector molecules into eukaryotic cells. Furthermore, Pseudovibrio genomes carry on average seven secondary metabolite biosynthesis clusters, reinforcing the role of Pseudovibrio spp. as potential producers of novel bioactive compounds. Tropodithietic acid, bacteriocin, and terpene biosynthesis clusters were highly conserved within the genus, suggesting an essential role in survival, for example through growth inhibition of bacterial competitors. Taken together, these results support the hypothesis that Pseudovibrio spp. have mutualistic relations with sponges. Oxford University Press 2018 Article REM application/pdf en http://irep.iium.edu.my/61482/3/7319_Comparative%20genomics%20highlights%20symbiotic%20capacities%20and%20high%20metabolic%20flexibility%20of%20the%20marine%20genus%20pseudovibrio.pdf Versluis, Dennis and Nijsse, Bart and Naim, Mohd Azrul and Koehorst, Jasper J. and Wiese, Jutta and Imhoff, Johannes F and Schaap, Peter J and van Passel, Mark W J and Smidt, Hauke and Sipkema, Detmer (2018) Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio. Genome Biology and Evolution, 10 (1). pp. 125-142. https://academic.oup.com/gbe
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QR Microbiology
spellingShingle QR Microbiology
Versluis, Dennis
Nijsse, Bart
Naim, Mohd Azrul
Koehorst, Jasper J.
Wiese, Jutta
Imhoff, Johannes F
Schaap, Peter J
van Passel, Mark W J
Smidt, Hauke
Sipkema, Detmer
Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio
description Pseudovibrio is a marine bacterial genus members of which are predominantly isolated from sessile marine animals, and particularly sponges. It has been hypothesized that Pseudovibrio spp. form mutualistic relationships with their hosts. Here, we studied Pseudovibrio phylogeny and genetic adaptations that may play a role in host colonization by comparative genomics of 31 Pseudovibrio strains, including 25 sponge isolates. All genomes were highly similar in terms of encoded core metabolic pathways, albeit with substantial differences in overall gene content. Based on gene composition, Pseudovibrio spp. clustered by geographic region, indicating geographic speciation. Furthermore, the fact that isolates from the Mediterranean Sea clustered by sponge species suggested host-specific adaptation or colonization. Genome analyses suggest that Pseudovibrio hongkongensis UST20140214-015BT is only distantly related to other Pseudovibrio spp., thereby challenging its status as typical Pseudovibrio member. All Pseudovibrio genomes were found to encode numerous proteins with SEL1 and tetratricopeptide repeats, which have been suggested to play a role in host colonization. For evasion of the host immune system, Pseudovibrio spp. may depend on type III, IV, and VI secretion systems that can inject effector molecules into eukaryotic cells. Furthermore, Pseudovibrio genomes carry on average seven secondary metabolite biosynthesis clusters, reinforcing the role of Pseudovibrio spp. as potential producers of novel bioactive compounds. Tropodithietic acid, bacteriocin, and terpene biosynthesis clusters were highly conserved within the genus, suggesting an essential role in survival, for example through growth inhibition of bacterial competitors. Taken together, these results support the hypothesis that Pseudovibrio spp. have mutualistic relations with sponges.
format Article
author Versluis, Dennis
Nijsse, Bart
Naim, Mohd Azrul
Koehorst, Jasper J.
Wiese, Jutta
Imhoff, Johannes F
Schaap, Peter J
van Passel, Mark W J
Smidt, Hauke
Sipkema, Detmer
author_facet Versluis, Dennis
Nijsse, Bart
Naim, Mohd Azrul
Koehorst, Jasper J.
Wiese, Jutta
Imhoff, Johannes F
Schaap, Peter J
van Passel, Mark W J
Smidt, Hauke
Sipkema, Detmer
author_sort Versluis, Dennis
title Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio
title_short Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio
title_full Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio
title_fullStr Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio
title_full_unstemmed Comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio
title_sort comparative genomics highlights symbiotic capacities and high metabolic flexibility of the marine genus pseudovibrio
publisher Oxford University Press
publishDate 2018
url http://irep.iium.edu.my/61482/3/7319_Comparative%20genomics%20highlights%20symbiotic%20capacities%20and%20high%20metabolic%20flexibility%20of%20the%20marine%20genus%20pseudovibrio.pdf
http://irep.iium.edu.my/61482/
https://academic.oup.com/gbe
_version_ 1643616013593346048
score 13.211869

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