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Antioxidant effects of some selected flavonoids: a structure-activity relationship based study

Objective: To investigate the antioxidant and radical scavenging activities of some selected flavonoids with respect to identify key positions responsible for antioxidant effects as well as the effect of derivatisation on the antioxidative effects. Design and method: Antioxidant potential was eva...

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Main Authors: Sarian, Murni Nazira, Ahmed, Qamar Uddin, Mat So'ad, Siti Zaiton, Alhassan, A.M, Murugesu, Suganya, Perumal, Vikneswari, Syed Mohamed, S.N.A, Latif, J
Format: Conference or Workshop Item
Language:English
English
Published: Universiti Putra Malaysia 2017
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/60999/1/IABS%202017%20PROCEEDINGS.pdf
http://irep.iium.edu.my/60999/2/IABS%202017_33_Murni%20Nazira%20Sarian-1.pdf
http://irep.iium.edu.my/60999/
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spelling my.iium.irep.609992017-12-31T15:18:04Z http://irep.iium.edu.my/60999/ Antioxidant effects of some selected flavonoids: a structure-activity relationship based study Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, A.M Murugesu, Suganya Perumal, Vikneswari Syed Mohamed, S.N.A Latif, J QD Chemistry Objective: To investigate the antioxidant and radical scavenging activities of some selected flavonoids with respect to identify key positions responsible for antioxidant effects as well as the effect of derivatisation on the antioxidative effects. Design and method: Antioxidant potential was evaluated using different sets of assays viz., rapid test by dot blot, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ABTS+ radical cation scavenging, ferric reducing antioxidant powder (FRAP) and xanthine oxidase inhibitory (XOI) assays. Results: It was determined that the total number and the configuration of hydroxyl group play an important role in regulating bioactivity of flavonoids in scavenging DPPH radical, ABTS+ radical cation and FRAP assays. Presence of catechol and the absence of C-2-C-3 double bond as well as ketonic group at C-4 reduced the xanthine oxidase inhibitory activity. Methylation and acetylation of hydroxyl groups at particular positions were also found to decrease the in vitro bioactivity of flavonoids. Conclusions: The results of this study will further help to understand the role of flavonoids as natural antioxidants which might facilitate in the development of nutritional products and semi synthetic analogs that retain substantial antioxidant capacity with minimal adverse effects. Keywords: Flavonoids; antioxidant activity; derivatisation, structure activity relationship Universiti Putra Malaysia 2017-08-01 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/60999/1/IABS%202017%20PROCEEDINGS.pdf application/pdf en http://irep.iium.edu.my/60999/2/IABS%202017_33_Murni%20Nazira%20Sarian-1.pdf Sarian, Murni Nazira and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton and Alhassan, A.M and Murugesu, Suganya and Perumal, Vikneswari and Syed Mohamed, S.N.A and Latif, J (2017) Antioxidant effects of some selected flavonoids: a structure-activity relationship based study. In: 2nd International Anatomical and Biomedical Scientific Conference 2017, 1-2 Aug 2017, Serdang, Selangor.
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QD Chemistry
spellingShingle QD Chemistry
Sarian, Murni Nazira
Ahmed, Qamar Uddin
Mat So'ad, Siti Zaiton
Alhassan, A.M
Murugesu, Suganya
Perumal, Vikneswari
Syed Mohamed, S.N.A
Latif, J
Antioxidant effects of some selected flavonoids: a structure-activity relationship based study
description Objective: To investigate the antioxidant and radical scavenging activities of some selected flavonoids with respect to identify key positions responsible for antioxidant effects as well as the effect of derivatisation on the antioxidative effects. Design and method: Antioxidant potential was evaluated using different sets of assays viz., rapid test by dot blot, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ABTS+ radical cation scavenging, ferric reducing antioxidant powder (FRAP) and xanthine oxidase inhibitory (XOI) assays. Results: It was determined that the total number and the configuration of hydroxyl group play an important role in regulating bioactivity of flavonoids in scavenging DPPH radical, ABTS+ radical cation and FRAP assays. Presence of catechol and the absence of C-2-C-3 double bond as well as ketonic group at C-4 reduced the xanthine oxidase inhibitory activity. Methylation and acetylation of hydroxyl groups at particular positions were also found to decrease the in vitro bioactivity of flavonoids. Conclusions: The results of this study will further help to understand the role of flavonoids as natural antioxidants which might facilitate in the development of nutritional products and semi synthetic analogs that retain substantial antioxidant capacity with minimal adverse effects. Keywords: Flavonoids; antioxidant activity; derivatisation, structure activity relationship
format Conference or Workshop Item
author Sarian, Murni Nazira
Ahmed, Qamar Uddin
Mat So'ad, Siti Zaiton
Alhassan, A.M
Murugesu, Suganya
Perumal, Vikneswari
Syed Mohamed, S.N.A
Latif, J
author_facet Sarian, Murni Nazira
Ahmed, Qamar Uddin
Mat So'ad, Siti Zaiton
Alhassan, A.M
Murugesu, Suganya
Perumal, Vikneswari
Syed Mohamed, S.N.A
Latif, J
author_sort Sarian, Murni Nazira
title Antioxidant effects of some selected flavonoids: a structure-activity relationship based study
title_short Antioxidant effects of some selected flavonoids: a structure-activity relationship based study
title_full Antioxidant effects of some selected flavonoids: a structure-activity relationship based study
title_fullStr Antioxidant effects of some selected flavonoids: a structure-activity relationship based study
title_full_unstemmed Antioxidant effects of some selected flavonoids: a structure-activity relationship based study
title_sort antioxidant effects of some selected flavonoids: a structure-activity relationship based study
publisher Universiti Putra Malaysia
publishDate 2017
url http://irep.iium.edu.my/60999/1/IABS%202017%20PROCEEDINGS.pdf
http://irep.iium.edu.my/60999/2/IABS%202017_33_Murni%20Nazira%20Sarian-1.pdf
http://irep.iium.edu.my/60999/
_version_ 1643615910779420672
score 13.211869

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