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Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion

Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic poly...

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Main Authors: Algadar, Gada Sulaiman, May, Kyaw Oo, Sengupta, Pinaki Ranjan, Mandal, Uttam Kumar, Md. Jaffri, Juliana, Chatterjee, Bappaditya
Format: Article
Language:English
Published: Wolters Kluwer 2017
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/58718/1/58718_Development%20of%20a%20binary%20carrier%20system%20consisting.pdf
http://irep.iium.edu.my/58718/
http://www.jpionline.org/temp/PharmInvestigations73142-6578907_014938.pdf
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spelling my.iium.irep.587182018-03-19T05:55:54Z http://irep.iium.edu.my/58718/ Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion Algadar, Gada Sulaiman May, Kyaw Oo Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Md. Jaffri, Juliana Chatterjee, Bappaditya RS Pharmacy and materia medica Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aims to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier. Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1:3.5 w/w) (SDPE). Another SD was prepared using only PEG (SDP) as a carrier for comparative study. The developed formulation was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid dispersion, which is responsible for the increase in dissolution rate of SD than a physical mixture. The release characteristics within 1 h from the higher to the lower value were the SDPE > SDP > physical mixture. Flow property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr index and Hausner ratio, the flow properties of SDPE was excellent. Conclusion: The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution of ibuprofen immediate release dosage form. Wolters Kluwer 2017-10-17 Article REM application/pdf en http://irep.iium.edu.my/58718/1/58718_Development%20of%20a%20binary%20carrier%20system%20consisting.pdf Algadar, Gada Sulaiman and May, Kyaw Oo and Sengupta, Pinaki Ranjan and Mandal, Uttam Kumar and Md. Jaffri, Juliana and Chatterjee, Bappaditya (2017) Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion. International Journal of Pharmaceutical Investigation, 7 (3). pp. 142-148. ISSN 2230-973X http://www.jpionline.org/temp/PharmInvestigations73142-6578907_014938.pdf 10.4103/jphi.JPHI_54_17
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Algadar, Gada Sulaiman
May, Kyaw Oo
Sengupta, Pinaki Ranjan
Mandal, Uttam Kumar
Md. Jaffri, Juliana
Chatterjee, Bappaditya
Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
description Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aims to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier. Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1:3.5 w/w) (SDPE). Another SD was prepared using only PEG (SDP) as a carrier for comparative study. The developed formulation was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid dispersion, which is responsible for the increase in dissolution rate of SD than a physical mixture. The release characteristics within 1 h from the higher to the lower value were the SDPE > SDP > physical mixture. Flow property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr index and Hausner ratio, the flow properties of SDPE was excellent. Conclusion: The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution of ibuprofen immediate release dosage form.
format Article
author Algadar, Gada Sulaiman
May, Kyaw Oo
Sengupta, Pinaki Ranjan
Mandal, Uttam Kumar
Md. Jaffri, Juliana
Chatterjee, Bappaditya
author_facet Algadar, Gada Sulaiman
May, Kyaw Oo
Sengupta, Pinaki Ranjan
Mandal, Uttam Kumar
Md. Jaffri, Juliana
Chatterjee, Bappaditya
author_sort Algadar, Gada Sulaiman
title Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_short Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_full Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_fullStr Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_full_unstemmed Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_sort development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
publisher Wolters Kluwer
publishDate 2017
url http://irep.iium.edu.my/58718/1/58718_Development%20of%20a%20binary%20carrier%20system%20consisting.pdf
http://irep.iium.edu.my/58718/
http://www.jpionline.org/temp/PharmInvestigations73142-6578907_014938.pdf
_version_ 1643615418863058944
score 13.211869

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