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Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics

The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of inco...

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Main Authors: Win, Thazin, Rajagopal, JeevanRaj, Mandal, Uttam Kumar, Sengupta, Pinaki, Chatterjee, Bappaditya
Format: Article
Language:English
English
English
Published: Latin American Journal of Pharmacy 2017
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf
http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf
http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf
http://irep.iium.edu.my/58691/
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spelling my.iium.irep.586912018-03-20T02:26:14Z http://irep.iium.edu.my/58691/ Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics Win, Thazin Rajagopal, JeevanRaj Mandal, Uttam Kumar Sengupta, Pinaki Chatterjee, Bappaditya RS Pharmacy and materia medica The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively. Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation. The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects on phase separation of the product. Latin American Journal of Pharmacy 2017-09 Article REM application/pdf en http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf application/pdf en http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf application/pdf en http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf Win, Thazin and Rajagopal, JeevanRaj and Mandal, Uttam Kumar and Sengupta, Pinaki and Chatterjee, Bappaditya (2017) Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics. Latin American Journal of Pharmacy, 36 (11). pp. 2144-2155. ISSN 0326 2383
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Win, Thazin
Rajagopal, JeevanRaj
Mandal, Uttam Kumar
Sengupta, Pinaki
Chatterjee, Bappaditya
Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
description The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively. Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation. The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects on phase separation of the product.
format Article
author Win, Thazin
Rajagopal, JeevanRaj
Mandal, Uttam Kumar
Sengupta, Pinaki
Chatterjee, Bappaditya
author_facet Win, Thazin
Rajagopal, JeevanRaj
Mandal, Uttam Kumar
Sengupta, Pinaki
Chatterjee, Bappaditya
author_sort Win, Thazin
title Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
title_short Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
title_full Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
title_fullStr Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
title_full_unstemmed Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
title_sort incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
publisher Latin American Journal of Pharmacy
publishDate 2017
url http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf
http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf
http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf
http://irep.iium.edu.my/58691/
_version_ 1643615412773978112
score 13.211869

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