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Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model

Introduction: Although there is a growing insight into the causes and mechanisms of kidney diseases, preventive and therapeutic measures are still few. The aim of this study was therefore to determine the renoprotective effect of tualang honey against high cholesterol diet induced acute kidney di...

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Main Authors: Hamad Mohamed, Zenab, Hamad Alfarisi, Hamad Abdulsalam, Abdullah, Nor Zamzila, Muhammad, Siti Aeshah @ Naznin, Abdul Rahim, Roslina
Format: Article
Language:English
Published: International Islamic University Malaysia 2017
Subjects:
R Medicine (General)
RC Internal medicine
Online Access:http://irep.iium.edu.my/58509/1/Abstract-Book-for-IMJM-final-v2-32.pdf
http://irep.iium.edu.my/58509/
http://iiumedic.net/imjm/v1/volume-16-supplementary-issue-no-1/
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spelling my.iium.irep.585092022-04-06T02:12:30Z http://irep.iium.edu.my/58509/ Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model Hamad Mohamed, Zenab Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Muhammad, Siti Aeshah @ Naznin Abdul Rahim, Roslina R Medicine (General) RC Internal medicine Introduction: Although there is a growing insight into the causes and mechanisms of kidney diseases, preventive and therapeutic measures are still few. The aim of this study was therefore to determine the renoprotective effect of tualang honey against high cholesterol diet induced acute kidney disease in an animal model. Materials and method: Ten female Sprague-Dawley rats were divided into two groups: high cholesterol diet (HCD) group, fed with 12% cholesterol diet with 0.3% cholic acid, and high cholesterol diet with tualang honey (HCD + TH) group, fed with HCD with oral daily dose of 1.4 g/kg/day of tualang honey by gavage. Biochemical analysis of lipid profile and renal function were performed at 48 hours, 7 days, and 6 weeks of the experiment. The animals were sacrificed at 6 weeks and the kidneys were harvested for histological examination. Results: There was no significant difference between the HCD and the HCD+TH groups in the level of TC. The mean serum LDL-c, TG and vLDL levels at completed 48 hours and 7 days for the HCD+TH group were lower as compared to the HCD group. The only significant difference in renal function test between HCD and HCD + TH groups reported were theserum creatinine at completed 48 hours. Histological examination of the kidney tissue of the HCD and HCD+TH groups at 6 weeks revealed segmental mesangial hypercellularity and mesangial matrix expansion of the glomeruli. Conclusion: Tualang honey supplementation has resulted in an improvement of the renal profile which is suggestive of its renoprotective effect. However, the histopathological examination of the kidneys revealed similar changesin both groups and this may be related to the dose of honey used in the study. Additionally, tualang honey showed improvement in LDL-c, triglyceride and vLDL levels indicating its lipid lowering activities. International Islamic University Malaysia 2017-09-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58509/1/Abstract-Book-for-IMJM-final-v2-32.pdf Hamad Mohamed, Zenab and Hamad Alfarisi, Hamad Abdulsalam and Abdullah, Nor Zamzila and Muhammad, Siti Aeshah @ Naznin and Abdul Rahim, Roslina (2017) Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model. International Medical Journal Malaysia (IMJM), 16 (supp. 1). p. 26. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/volume-16-supplementary-issue-no-1/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RC Internal medicine
spellingShingle R Medicine (General)
RC Internal medicine
Hamad Mohamed, Zenab
Hamad Alfarisi, Hamad Abdulsalam
Abdullah, Nor Zamzila
Muhammad, Siti Aeshah @ Naznin
Abdul Rahim, Roslina
Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
description Introduction: Although there is a growing insight into the causes and mechanisms of kidney diseases, preventive and therapeutic measures are still few. The aim of this study was therefore to determine the renoprotective effect of tualang honey against high cholesterol diet induced acute kidney disease in an animal model. Materials and method: Ten female Sprague-Dawley rats were divided into two groups: high cholesterol diet (HCD) group, fed with 12% cholesterol diet with 0.3% cholic acid, and high cholesterol diet with tualang honey (HCD + TH) group, fed with HCD with oral daily dose of 1.4 g/kg/day of tualang honey by gavage. Biochemical analysis of lipid profile and renal function were performed at 48 hours, 7 days, and 6 weeks of the experiment. The animals were sacrificed at 6 weeks and the kidneys were harvested for histological examination. Results: There was no significant difference between the HCD and the HCD+TH groups in the level of TC. The mean serum LDL-c, TG and vLDL levels at completed 48 hours and 7 days for the HCD+TH group were lower as compared to the HCD group. The only significant difference in renal function test between HCD and HCD + TH groups reported were theserum creatinine at completed 48 hours. Histological examination of the kidney tissue of the HCD and HCD+TH groups at 6 weeks revealed segmental mesangial hypercellularity and mesangial matrix expansion of the glomeruli. Conclusion: Tualang honey supplementation has resulted in an improvement of the renal profile which is suggestive of its renoprotective effect. However, the histopathological examination of the kidneys revealed similar changesin both groups and this may be related to the dose of honey used in the study. Additionally, tualang honey showed improvement in LDL-c, triglyceride and vLDL levels indicating its lipid lowering activities.
format Article
author Hamad Mohamed, Zenab
Hamad Alfarisi, Hamad Abdulsalam
Abdullah, Nor Zamzila
Muhammad, Siti Aeshah @ Naznin
Abdul Rahim, Roslina
author_facet Hamad Mohamed, Zenab
Hamad Alfarisi, Hamad Abdulsalam
Abdullah, Nor Zamzila
Muhammad, Siti Aeshah @ Naznin
Abdul Rahim, Roslina
author_sort Hamad Mohamed, Zenab
title Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_short Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_full Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_fullStr Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_full_unstemmed Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_sort renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
publisher International Islamic University Malaysia
publishDate 2017
url http://irep.iium.edu.my/58509/1/Abstract-Book-for-IMJM-final-v2-32.pdf
http://irep.iium.edu.my/58509/
http://iiumedic.net/imjm/v1/volume-16-supplementary-issue-no-1/
_version_ 1729702899072630784
score 13.211869

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