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Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs

Osteoarthritis (OA) is a progression of degenerative joint disease which can cause disability. Previous study shown that thickness of subchondral bone plate (Sbp), trabecular bone (Tb) and calcified cartilage (CC) increases along the progression of OA. However, none of these studies provide evidence...

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Main Authors: Md Yusof, Nur Azirah, Talib, Ain Aisyah, Akman, Akma Azmiera, Zamli, Zaitunnatakhin
Format: Conference or Workshop Item
Language:English
Published: Universiti Putra Malaysia 2017
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/58137/1/Association%20between%20the%20subchondral%20bone%20plate%20and%20articular%20cartilage%20thickness%20during%20the%20progression%20of%20osteoarthritis%20in%20Dunkin%20Hartley%20guinea%20pigs.pdf
http://irep.iium.edu.my/58137/
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spelling my.iium.irep.581372017-12-31T15:12:21Z http://irep.iium.edu.my/58137/ Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs Md Yusof, Nur Azirah Talib, Ain Aisyah Akman, Akma Azmiera Zamli, Zaitunnatakhin R Medicine (General) Osteoarthritis (OA) is a progression of degenerative joint disease which can cause disability. Previous study shown that thickness of subchondral bone plate (Sbp), trabecular bone (Tb) and calcified cartilage (CC) increases along the progression of OA. However, none of these studies provide evidence of their association, especially during early stage of OA. Thus, this study aims to determine the association between the CC and Sbp thickness during the development of OA in Dunkin Hartley (DH) guinea pigs. Micro-computed tomography (Micro-CT) analyser software was used to measure the Sbp thickness (Sbp Th) in medial and lateral side of DH tibia at 10, 20 and 30 weeks of age. Histological analysis was used to determine the thickness of CC, uncalcified cartilage (unCC) and total articular cartilage (AC), and assess severity of the AC degeneration. The results showed that the Sbp [Medial, p = 0.001; Lateral: p = 0.001] and CC [Medial, p = 0.013; Lateral, p = 0.005] was thicker, but the unCC [Medial, p = 0.004; Lateral, p = 0.004] was thinner, in the medial than lateral side of DH tibia at all time points. In the medial side, a significant increase of Sbp Th and CC Th was observed between 10 and 20 weeks of age [(Sbp Medial, p = 0.01; Sbp Lateral, p = 0.01), (CC Medial, p = 0.045; CC Lateral, p = 0.014)]. In contrast, the unCC thickness was decreased with ageing. Since these changes were significantly associated with the AC degeneration, it may suggest that these events play an important role during the initiation and progression of OA. Universiti Putra Malaysia 2017 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/58137/1/Association%20between%20the%20subchondral%20bone%20plate%20and%20articular%20cartilage%20thickness%20during%20the%20progression%20of%20osteoarthritis%20in%20Dunkin%20Hartley%20guinea%20pigs.pdf Md Yusof, Nur Azirah and Talib, Ain Aisyah and Akman, Akma Azmiera and Zamli, Zaitunnatakhin (2017) Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs. In: 2nd International Anatomical and Biomedical Scientific Conference 2017, 1-2 Aug 2017, Serdang, Selangor.
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Md Yusof, Nur Azirah
Talib, Ain Aisyah
Akman, Akma Azmiera
Zamli, Zaitunnatakhin
Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs
description Osteoarthritis (OA) is a progression of degenerative joint disease which can cause disability. Previous study shown that thickness of subchondral bone plate (Sbp), trabecular bone (Tb) and calcified cartilage (CC) increases along the progression of OA. However, none of these studies provide evidence of their association, especially during early stage of OA. Thus, this study aims to determine the association between the CC and Sbp thickness during the development of OA in Dunkin Hartley (DH) guinea pigs. Micro-computed tomography (Micro-CT) analyser software was used to measure the Sbp thickness (Sbp Th) in medial and lateral side of DH tibia at 10, 20 and 30 weeks of age. Histological analysis was used to determine the thickness of CC, uncalcified cartilage (unCC) and total articular cartilage (AC), and assess severity of the AC degeneration. The results showed that the Sbp [Medial, p = 0.001; Lateral: p = 0.001] and CC [Medial, p = 0.013; Lateral, p = 0.005] was thicker, but the unCC [Medial, p = 0.004; Lateral, p = 0.004] was thinner, in the medial than lateral side of DH tibia at all time points. In the medial side, a significant increase of Sbp Th and CC Th was observed between 10 and 20 weeks of age [(Sbp Medial, p = 0.01; Sbp Lateral, p = 0.01), (CC Medial, p = 0.045; CC Lateral, p = 0.014)]. In contrast, the unCC thickness was decreased with ageing. Since these changes were significantly associated with the AC degeneration, it may suggest that these events play an important role during the initiation and progression of OA.
format Conference or Workshop Item
author Md Yusof, Nur Azirah
Talib, Ain Aisyah
Akman, Akma Azmiera
Zamli, Zaitunnatakhin
author_facet Md Yusof, Nur Azirah
Talib, Ain Aisyah
Akman, Akma Azmiera
Zamli, Zaitunnatakhin
author_sort Md Yusof, Nur Azirah
title Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs
title_short Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs
title_full Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs
title_fullStr Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs
title_full_unstemmed Association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in Dunkin Hartley guinea pigs
title_sort association between the subchondral bone plate and articular cartilage thickness during the progression of osteoarthritis in dunkin hartley guinea pigs
publisher Universiti Putra Malaysia
publishDate 2017
url http://irep.iium.edu.my/58137/1/Association%20between%20the%20subchondral%20bone%20plate%20and%20articular%20cartilage%20thickness%20during%20the%20progression%20of%20osteoarthritis%20in%20Dunkin%20Hartley%20guinea%20pigs.pdf
http://irep.iium.edu.my/58137/
_version_ 1643615288811323392
score 13.211869

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