Staff View: The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)

The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)

Introduction: Over accumulation of polyamines is one of the causes of cancer because polyamines could promote the cancer cells growth. Due to the lack of specificity and increased reports of side effects in the current cancer treatment, one of the strategies to overcome the challenges is by utilizin...

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Main Authors:	Jamil, Masnizahani, Abdul Ghani, Radiah, Sahabudeen, Adzly Hairee, Fong, Fiona How Ni
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	QD Chemistry RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/58032/20/58032.pdf http://irep.iium.edu.my/58032/
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spelling	my.iium.irep.580322017-08-18T07:51:30Z http://irep.iium.edu.my/58032/ The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7) Jamil, Masnizahani Abdul Ghani, Radiah Sahabudeen, Adzly Hairee Fong, Fiona How Ni QD Chemistry RM300 Drugs and their action Introduction: Over accumulation of polyamines is one of the causes of cancer because polyamines could promote the cancer cells growth. Due to the lack of specificity and increased reports of side effects in the current cancer treatment, one of the strategies to overcome the challenges is by utilizing polyamines as vectors of known cytotoxic compounds to target the cancer cells. Therefore, this study was aimed to investigate the cytotoxicity effects of Spermidine Sulphur Analogues Type 1 and Type 2 (SSA-1 and SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cell (MCF-7). Materials and method: The cytotoxicity studies of SSA-1 and SSA-2 against in vitro cells: A549, HCT-8, and MCF-7 were carried out by using MTT assay and the IC50 in each cell was determined. Results: SSA-1 exhibited cytotoxicity effects in all selected cell lines with IC50 between 2.0 mM to 5.3 mM. While SSA-2 also exhibited cytotoxicity effects in all cell lines with IC50 between 0.8 mM to 5.0 mM. Conclusion: SSA-1 and SSA-2 were cytotoxic against A549, HCT-8, and MCF-7. However, the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth. Hence, it is suggested that further study on the cytotoxicity effects of SSA-1 and SSA-2 in other cell lines should be conducted and the formulation of the analogues based on sulphur should be amended by conjugating it with selected metal. 2017 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/58032/20/58032.pdf Jamil, Masnizahani and Abdul Ghani, Radiah and Sahabudeen, Adzly Hairee and Fong, Fiona How Ni (2017) The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7). In: Medical Research Symposium 2017, 10th August 2017, Kuantan, Pahang Darul Makmur, Malaysia. (Unpublished)
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	QD Chemistry RM300 Drugs and their action
spellingShingle	QD Chemistry RM300 Drugs and their action Jamil, Masnizahani Abdul Ghani, Radiah Sahabudeen, Adzly Hairee Fong, Fiona How Ni The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
description	Introduction: Over accumulation of polyamines is one of the causes of cancer because polyamines could promote the cancer cells growth. Due to the lack of specificity and increased reports of side effects in the current cancer treatment, one of the strategies to overcome the challenges is by utilizing polyamines as vectors of known cytotoxic compounds to target the cancer cells. Therefore, this study was aimed to investigate the cytotoxicity effects of Spermidine Sulphur Analogues Type 1 and Type 2 (SSA-1 and SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cell (MCF-7). Materials and method: The cytotoxicity studies of SSA-1 and SSA-2 against in vitro cells: A549, HCT-8, and MCF-7 were carried out by using MTT assay and the IC50 in each cell was determined. Results: SSA-1 exhibited cytotoxicity effects in all selected cell lines with IC50 between 2.0 mM to 5.3 mM. While SSA-2 also exhibited cytotoxicity effects in all cell lines with IC50 between 0.8 mM to 5.0 mM. Conclusion: SSA-1 and SSA-2 were cytotoxic against A549, HCT-8, and MCF-7. However, the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth. Hence, it is suggested that further study on the cytotoxicity effects of SSA-1 and SSA-2 in other cell lines should be conducted and the formulation of the analogues based on sulphur should be amended by conjugating it with selected metal.
format	Conference or Workshop Item
author	Jamil, Masnizahani Abdul Ghani, Radiah Sahabudeen, Adzly Hairee Fong, Fiona How Ni
author_facet	Jamil, Masnizahani Abdul Ghani, Radiah Sahabudeen, Adzly Hairee Fong, Fiona How Ni
author_sort	Jamil, Masnizahani
title	The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_short	The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_full	The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_fullStr	The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_full_unstemmed	The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)
title_sort	cytotoxicity effects of spermidine sulphur analogues type 1 (ssa-1) and type 2 (ssa-2) against human lung adenocarcinoma cells (a549), human colorectal adenocarcinoma cells (hct-8), and human breast adenocarcinoma cells (mcf-7)
publishDate	2017
url	http://irep.iium.edu.my/58032/20/58032.pdf http://irep.iium.edu.my/58032/
_version_	1643615270197002240
score	13.211869

The cytotoxicity effects of spermidine sulphur analogues Type 1 (SSA-1) and Type 2 (SSA-2) against human lung adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8), and human breast adenocarcinoma cells (MCF-7)

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