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A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients

Background: Cervical spondylotic myelopathy (CSM) is the commonest cause of spinal cord dysfunction and MRI remains the imaging of choice for CSM. However, its findings are not completely specific for clinically significant CSM. Objectives: This cross-sectional study aimed to determine the pathoa...

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Main Authors: Zakaria@Mohamad, Zamzuri, Sharifudin, Mohd Ariff, Din, Hishamudin, Abdul Aziz, Azian
Format: Conference or Workshop Item
Language:English
Published: 2016
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/57985/1/Jurnal%20MSS%20-%20Mr%20Zam%202016.pdf
http://irep.iium.edu.my/57985/
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spelling my.iium.irep.579852017-10-19T07:41:43Z http://irep.iium.edu.my/57985/ A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Din, Hishamudin Abdul Aziz, Azian R Medicine (General) Background: Cervical spondylotic myelopathy (CSM) is the commonest cause of spinal cord dysfunction and MRI remains the imaging of choice for CSM. However, its findings are not completely specific for clinically significant CSM. Objectives: This cross-sectional study aimed to determine the pathoanatomy of CSM and analyze the correlation between clinical and MRI findings. Methods: Patients ages 40 to 80 years old with CSM were recruited. Clinical parameters include myelopathic signs and other specific signs. MRI findings include level of compression, degenerative pathology and parameters for cord compression. Results: Thirty patients were recruited. Commonest (60%) myelopathic signs observed were positive Hoffmann's sign and brachioradialis sign. 90% of patients had osteophyte formation, 36.7% with single-level facet hypertrophy, and 23.3% had thickening of ligamentum flavum. Myelopathic signs and other specific signs significantly correlate with the cervical cord compression and observed in patients with smaller cord diameter. Positive correlation between the clinical key features with MRI parameters observed for canal and cord diameter. The transverse cord diameter, cord compression ratio and approximate cord area were the only independent variables related to almost all the positive clinical signs. All have moderate to strong correlation with the clinical findings. Conclusions: The MRI parameters with significant correlation reflect compression of the cord, indicating their major role in the pathophysiology of CSM. They may play significant roles in predicting roles in predicting the severity and outcome of CSM. 2016-08-08 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/57985/1/Jurnal%20MSS%20-%20Mr%20Zam%202016.pdf Zakaria@Mohamad, Zamzuri and Sharifudin, Mohd Ariff and Din, Hishamudin and Abdul Aziz, Azian (2016) A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients. In: 4th International MSS Scientific Congress, 8-10 Aug 2016, G Hotel Penang, Malaysia. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Zakaria@Mohamad, Zamzuri
Sharifudin, Mohd Ariff
Din, Hishamudin
Abdul Aziz, Azian
A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients
description Background: Cervical spondylotic myelopathy (CSM) is the commonest cause of spinal cord dysfunction and MRI remains the imaging of choice for CSM. However, its findings are not completely specific for clinically significant CSM. Objectives: This cross-sectional study aimed to determine the pathoanatomy of CSM and analyze the correlation between clinical and MRI findings. Methods: Patients ages 40 to 80 years old with CSM were recruited. Clinical parameters include myelopathic signs and other specific signs. MRI findings include level of compression, degenerative pathology and parameters for cord compression. Results: Thirty patients were recruited. Commonest (60%) myelopathic signs observed were positive Hoffmann's sign and brachioradialis sign. 90% of patients had osteophyte formation, 36.7% with single-level facet hypertrophy, and 23.3% had thickening of ligamentum flavum. Myelopathic signs and other specific signs significantly correlate with the cervical cord compression and observed in patients with smaller cord diameter. Positive correlation between the clinical key features with MRI parameters observed for canal and cord diameter. The transverse cord diameter, cord compression ratio and approximate cord area were the only independent variables related to almost all the positive clinical signs. All have moderate to strong correlation with the clinical findings. Conclusions: The MRI parameters with significant correlation reflect compression of the cord, indicating their major role in the pathophysiology of CSM. They may play significant roles in predicting roles in predicting the severity and outcome of CSM.
format Conference or Workshop Item
author Zakaria@Mohamad, Zamzuri
Sharifudin, Mohd Ariff
Din, Hishamudin
Abdul Aziz, Azian
author_facet Zakaria@Mohamad, Zamzuri
Sharifudin, Mohd Ariff
Din, Hishamudin
Abdul Aziz, Azian
author_sort Zakaria@Mohamad, Zamzuri
title A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients
title_short A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients
title_full A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients
title_fullStr A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients
title_full_unstemmed A morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients
title_sort morphometric analysis of the pathoanatomy of cervical spondylotic myelopathy and the correlation between magnetic resonance imaging findings and clinical presentation of patients
publishDate 2016
url http://irep.iium.edu.my/57985/1/Jurnal%20MSS%20-%20Mr%20Zam%202016.pdf
http://irep.iium.edu.my/57985/
_version_ 1643615258329219072
score 13.211869

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