The in vivo study of open fracture in New Zealand white rabbit using orthopaedic metal implant coated with silver composite – A pilot study
INTRODUCTION: Bacterial infection during implant placement is a serious complication. The reason for this infection is mainly due to contamination during surgical implantation with the formation of a resistant biofilm at the implant surface. The infection risks may be overcome by application of ort...
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| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/57852/31/57852.pdf http://irep.iium.edu.my/57852/ http://www.apoatrauma.com/eposters.html |
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| Summary: | INTRODUCTION:
Bacterial infection during implant placement is a serious complication. The reason for this infection is mainly due to contamination during surgical implantation with the formation of a resistant biofilm at the implant surface. The infection risks may be overcome by application of orthopaedic metallic implant coated with 3% silver composite as alternative treatment of implant-infection related. The purpose of this study was to investigate the potential effect of test material against infection through in vivo experimental setting.
METHODS:
The effect of silver coated as antibacterial agent on orthopaedic metal implant was evaluated in New Zealand White Rabbit. The study was performed by surgically implanted at right tibia (silver coated plate) and non-coated implant at left tibia (non-coated plate) after six hours of exposure at surgical site. The subject was observed daily for infection effect up to three weeks. Microbial analyze was performed after euthanasia for assessment day. No antibiotics were administered. Animal was sacrificed at 3 weeks and evaluated for infection. Culture for the rabbit was taken at sacrifice after 3 week assessment duration. The organism on the swab on the implanted plate was inoculated on the sterile nutrient agar. After that, it was incubated for 24 hours before reading the colony.
RESULT:
The culture result on the nutrient agar showed that there is no colony bacteria growth on the silver coated implant meanwhile the non-coated implant has a few colony bacteria at the nutrient agar plate in 3 weeks observation period after 24 hours incubation.
DISCUSSIONS:
The outcome of this study revealed positive response of the silver as antibacterial agent. The study is still ongoing.
CONCLUSION:
This result suggested that orthopaedic metal implant coated with silver composite has the intended antibacterial properties in 3 weeks period and may provide potential as bacteriostatic or bactericidal properties against infection. |
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