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The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling

Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius work...

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Main Authors: Zhang, Xudong, Wang, William, Nordin, Anis Nurashikin, Li, Fang, Jang, Sunghoon, Voiculescu, Ioana R.
Format: Article
Language:English
English
Published: Elsevier B.V. 2017
Subjects:
QA Mathematics
QA75 Electronic computers. Computer science
Online Access:http://irep.iium.edu.my/57338/1/57338_The%20influence%20of%20the%20electrode_article.pdf
http://irep.iium.edu.my/57338/2/57338_The%20influence%20of%20the%20electrode_article_SCOPUS.pdf
http://irep.iium.edu.my/57338/
http://www.sciencedirect.com/science/article/pii/S0925400517304641
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spelling my.iium.irep.573382018-10-25T06:07:38Z http://irep.iium.edu.my/57338/ The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling Zhang, Xudong Wang, William Nordin, Anis Nurashikin Li, Fang Jang, Sunghoon Voiculescu, Ioana R. QA Mathematics QA75 Electronic computers. Computer science Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius working electrodes generate more sensitive impedance shift to cell density change. Also, the smaller radius of working electrodes yield higher impedance values, which improves signal-to-noise ratio. In a range from 1.0 mm to 3.5 mm, the distance between the working and counter electrodes does not affect impedance measurements. However, the distance should be large enough to prevent the current from directly bypassing the cells between the electrodes. A mathematical model has been developed to analyze the distribution of electric potential and current over the sensing electrodes of ECIS sensors, which is helpful in understanding the mechanisms of ECIS. This mathematical model, supported by experimental data and finite element analysis, is able to illustrate a quantitative relationship between cell impedance and cell characteristics. This model can be used to optimize the design of ECIS sensors and interpret cell behavior. Elsevier B.V. 2017-08-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57338/1/57338_The%20influence%20of%20the%20electrode_article.pdf application/pdf en http://irep.iium.edu.my/57338/2/57338_The%20influence%20of%20the%20electrode_article_SCOPUS.pdf Zhang, Xudong and Wang, William and Nordin, Anis Nurashikin and Li, Fang and Jang, Sunghoon and Voiculescu, Ioana R. (2017) The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling. Sensors and Actuators, B: Chemical, 247. pp. 780-790. ISSN 0925-4005 http://www.sciencedirect.com/science/article/pii/S0925400517304641 10.1016/j.snb.2017.03.047
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QA Mathematics
QA75 Electronic computers. Computer science
spellingShingle QA Mathematics
QA75 Electronic computers. Computer science
Zhang, Xudong
Wang, William
Nordin, Anis Nurashikin
Li, Fang
Jang, Sunghoon
Voiculescu, Ioana R.
The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
description Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius working electrodes generate more sensitive impedance shift to cell density change. Also, the smaller radius of working electrodes yield higher impedance values, which improves signal-to-noise ratio. In a range from 1.0 mm to 3.5 mm, the distance between the working and counter electrodes does not affect impedance measurements. However, the distance should be large enough to prevent the current from directly bypassing the cells between the electrodes. A mathematical model has been developed to analyze the distribution of electric potential and current over the sensing electrodes of ECIS sensors, which is helpful in understanding the mechanisms of ECIS. This mathematical model, supported by experimental data and finite element analysis, is able to illustrate a quantitative relationship between cell impedance and cell characteristics. This model can be used to optimize the design of ECIS sensors and interpret cell behavior.
format Article
author Zhang, Xudong
Wang, William
Nordin, Anis Nurashikin
Li, Fang
Jang, Sunghoon
Voiculescu, Ioana R.
author_facet Zhang, Xudong
Wang, William
Nordin, Anis Nurashikin
Li, Fang
Jang, Sunghoon
Voiculescu, Ioana R.
author_sort Zhang, Xudong
title The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_short The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_full The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_fullStr The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_full_unstemmed The influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ECIS) and its mathematical modeling
title_sort influence of the electrode dimension on the detection sensitivity of electric cell–substrate impedance sensing (ecis) and its mathematical modeling
publisher Elsevier B.V.
publishDate 2017
url http://irep.iium.edu.my/57338/1/57338_The%20influence%20of%20the%20electrode_article.pdf
http://irep.iium.edu.my/57338/2/57338_The%20influence%20of%20the%20electrode_article_SCOPUS.pdf
http://irep.iium.edu.my/57338/
http://www.sciencedirect.com/science/article/pii/S0925400517304641
_version_ 1643617765758599168
score 13.211869

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