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Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmod...

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Main Authors: Mohamad Zin, Noraziah, Baba, Mohd Shukri, Zainal-Abidin, Abu Hassan, Latip, Jalifah, Mazlan, Noor Wini, RuAngelie, Edrada-Ebel
Format: Article
Language:English
English
English
Published: Dove Medical Press Ltd. 2017
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/57103/1/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity.pdf
http://irep.iium.edu.my/57103/2/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_SCOPUS.pdf
http://irep.iium.edu.my/57103/3/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_WOS.pdf
http://irep.iium.edu.my/57103/
https://www.dovepress.com/gancidin-w-a-potential-low-toxicity-antimalarial-agent-isolated-from-a-peer-reviewed-fulltext-article-DDDT
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spelling my.iium.irep.571032019-10-14T01:43:14Z http://irep.iium.edu.my/57103/ Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10 Mohamad Zin, Noraziah Baba, Mohd Shukri Zainal-Abidin, Abu Hassan Latip, Jalifah Mazlan, Noor Wini RuAngelie, Edrada-Ebel QD Chemistry Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.25 and 3.125 mu g kg(-1) body weight on day four using the 4-day suppression test method on male ICR strain mice. Comparing GW at both concentrations with quinine hydrochloride and normal saline as positive and negative controls, respectively, 50% of the mice treated with 3.125 mu g kg-1 body weight managed to survive for more than 11 months after infection, which almost reached the life span of normal mice. Biochemical tests of selected enzymes and proteins in blood samples of mice treated with GW were also within normal levels; in addition, no abnormalities or injuries were found on internal vital organs. These findings indicated that this isolated bioactive compound from Streptomyces SUK10 exhibits very low toxicity and is a good candidate for potential use as an antimalarial agent in an animal model. Dove Medical Press Ltd. 2017-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57103/1/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity.pdf application/pdf en http://irep.iium.edu.my/57103/2/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/57103/3/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_WOS.pdf Mohamad Zin, Noraziah and Baba, Mohd Shukri and Zainal-Abidin, Abu Hassan and Latip, Jalifah and Mazlan, Noor Wini and RuAngelie, Edrada-Ebel (2017) Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10. Drug Design, Development and Therapy, 11. pp. 351-363. ISSN 1177-8881 https://www.dovepress.com/gancidin-w-a-potential-low-toxicity-antimalarial-agent-isolated-from-a-peer-reviewed-fulltext-article-DDDT
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic QD Chemistry
spellingShingle QD Chemistry
Mohamad Zin, Noraziah
Baba, Mohd Shukri
Zainal-Abidin, Abu Hassan
Latip, Jalifah
Mazlan, Noor Wini
RuAngelie, Edrada-Ebel
Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
description Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.25 and 3.125 mu g kg(-1) body weight on day four using the 4-day suppression test method on male ICR strain mice. Comparing GW at both concentrations with quinine hydrochloride and normal saline as positive and negative controls, respectively, 50% of the mice treated with 3.125 mu g kg-1 body weight managed to survive for more than 11 months after infection, which almost reached the life span of normal mice. Biochemical tests of selected enzymes and proteins in blood samples of mice treated with GW were also within normal levels; in addition, no abnormalities or injuries were found on internal vital organs. These findings indicated that this isolated bioactive compound from Streptomyces SUK10 exhibits very low toxicity and is a good candidate for potential use as an antimalarial agent in an animal model.
format Article
author Mohamad Zin, Noraziah
Baba, Mohd Shukri
Zainal-Abidin, Abu Hassan
Latip, Jalifah
Mazlan, Noor Wini
RuAngelie, Edrada-Ebel
author_facet Mohamad Zin, Noraziah
Baba, Mohd Shukri
Zainal-Abidin, Abu Hassan
Latip, Jalifah
Mazlan, Noor Wini
RuAngelie, Edrada-Ebel
author_sort Mohamad Zin, Noraziah
title Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_short Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_full Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_fullStr Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_full_unstemmed Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
title_sort gancidin w, a potential low-toxicity antimalarial agent isolated from an endophytic streptomyces suk10
publisher Dove Medical Press Ltd.
publishDate 2017
url http://irep.iium.edu.my/57103/1/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity.pdf
http://irep.iium.edu.my/57103/2/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_SCOPUS.pdf
http://irep.iium.edu.my/57103/3/57103_Gancidin%20W%2C%20a%20potential%20low-toxicity_WOS.pdf
http://irep.iium.edu.my/57103/
https://www.dovepress.com/gancidin-w-a-potential-low-toxicity-antimalarial-agent-isolated-from-a-peer-reviewed-fulltext-article-DDDT
_version_ 1648739692761317376
score 13.211869

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