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Effect of neutron irradiation on the physicochemical properties of naproxen sodium

Abstract Pharmaceutical drug delivery systems for non-steroidal anti-inflammatory drugs involve targeted delivery or controlled release of the drug. The most common method to monitor the in vivo behavior of pharmaceutical dosage form is neutron activation based gamma scintigraphy. It is necessary t...

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Main Authors: D, Sithra, Rahman, Md. Mokhlesur, I, Ibrahim, Awang, Mohamed
Format: Article
Language:English
Published: Trade Science Inc 2016
Subjects:
QD Chemistry
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/56589/1/Naproxen-sodium_IIUM_CUCMS_2016.pdf
http://irep.iium.edu.my/56589/
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spelling my.iium.irep.565892017-07-03T07:28:47Z http://irep.iium.edu.my/56589/ Effect of neutron irradiation on the physicochemical properties of naproxen sodium D, Sithra Rahman, Md. Mokhlesur I, Ibrahim Awang, Mohamed QD Chemistry RS Pharmacy and materia medica Abstract Pharmaceutical drug delivery systems for non-steroidal anti-inflammatory drugs involve targeted delivery or controlled release of the drug. The most common method to monitor the in vivo behavior of pharmaceutical dosage form is neutron activation based gamma scintigraphy. It is necessary to ensure that the process of neutron irradiation does not affect the physicochemical properties of the formulated drug and its dosage form. This study, the effect of neutron irradiation on the physicochemical properties of naproxen sodium is investigated and it is also; selected as the model drug. The process of neutron irradiation was carried out at the Malaysian Nuclear Agency using the TRIGA MK II reactor. After irradiation times of 1, 2, 3, 4, 5 and 30 min, the effect of neutron irradiation on physicochemical properties of naproxen sodium was investigated using scanning electron microscope (SEM), gas chromatograph-mass spectrometer (GCMS), Fourier transform infrared spectrometer (FTIR) and ifferential scanning calorimeter (DSC). The physicochemical properties of non-irradiated naproxen sodium were compared to the irradiated naproxen sodium samples. Colour changes after irradiation was observed. Results of analysis of SEM and FTIR spectrometer showed changes in the physicochemical properties of naproxen sodium when duration of irradiation was ncreased. There were no major changes in the result of GC-MS and DSC. Based on the results obtained, it can be concluded that naproxen sodium is a suitable drug that can be used for neutron activation based gamma scintigraphy. The maximum irradiation time that naproxen sodium can withstand without changes in its physicochemical properties is 3 min. Trade Science Inc 2016-12-23 Article REM application/pdf en http://irep.iium.edu.my/56589/1/Naproxen-sodium_IIUM_CUCMS_2016.pdf D, Sithra and Rahman, Md. Mokhlesur and I, Ibrahim and Awang, Mohamed (2016) Effect of neutron irradiation on the physicochemical properties of naproxen sodium. ChemXpress, 9 (6). pp. 1-15. ISSN 2320-1967 http://www.tsijournals.com/journals/chemxpress.html
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
RS Pharmacy and materia medica
spellingShingle QD Chemistry
RS Pharmacy and materia medica
D, Sithra
Rahman, Md. Mokhlesur
I, Ibrahim
Awang, Mohamed
Effect of neutron irradiation on the physicochemical properties of naproxen sodium
description Abstract Pharmaceutical drug delivery systems for non-steroidal anti-inflammatory drugs involve targeted delivery or controlled release of the drug. The most common method to monitor the in vivo behavior of pharmaceutical dosage form is neutron activation based gamma scintigraphy. It is necessary to ensure that the process of neutron irradiation does not affect the physicochemical properties of the formulated drug and its dosage form. This study, the effect of neutron irradiation on the physicochemical properties of naproxen sodium is investigated and it is also; selected as the model drug. The process of neutron irradiation was carried out at the Malaysian Nuclear Agency using the TRIGA MK II reactor. After irradiation times of 1, 2, 3, 4, 5 and 30 min, the effect of neutron irradiation on physicochemical properties of naproxen sodium was investigated using scanning electron microscope (SEM), gas chromatograph-mass spectrometer (GCMS), Fourier transform infrared spectrometer (FTIR) and ifferential scanning calorimeter (DSC). The physicochemical properties of non-irradiated naproxen sodium were compared to the irradiated naproxen sodium samples. Colour changes after irradiation was observed. Results of analysis of SEM and FTIR spectrometer showed changes in the physicochemical properties of naproxen sodium when duration of irradiation was ncreased. There were no major changes in the result of GC-MS and DSC. Based on the results obtained, it can be concluded that naproxen sodium is a suitable drug that can be used for neutron activation based gamma scintigraphy. The maximum irradiation time that naproxen sodium can withstand without changes in its physicochemical properties is 3 min.
format Article
author D, Sithra
Rahman, Md. Mokhlesur
I, Ibrahim
Awang, Mohamed
author_facet D, Sithra
Rahman, Md. Mokhlesur
I, Ibrahim
Awang, Mohamed
author_sort D, Sithra
title Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_short Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_full Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_fullStr Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_full_unstemmed Effect of neutron irradiation on the physicochemical properties of naproxen sodium
title_sort effect of neutron irradiation on the physicochemical properties of naproxen sodium
publisher Trade Science Inc
publishDate 2016
url http://irep.iium.edu.my/56589/1/Naproxen-sodium_IIUM_CUCMS_2016.pdf
http://irep.iium.edu.my/56589/
http://www.tsijournals.com/journals/chemxpress.html
_version_ 1643614950991593472
score 13.211869

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