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Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra

Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castra...

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Main Authors: Bradley, David A., Abdul Sani, Siti Fairus, Ahmad Shaharuddin, Siti Shafiqah, Collins, Sean M., Hugtenburg, Richard P., Abdul Rashid, Hairul Azhar, Zulkepley, Nurul Najua, Maah, Mohd Jamil
Format: Article
Language:English
English
English
Published: Elsevier B.V. 2018
Subjects:
QC Physics
Online Access:http://irep.iium.edu.my/55362/2/55362_Doped%20silica%20fibre%20thermoluminescence_SCOPUS.pdf
http://irep.iium.edu.my/55362/13/55362_Doped%20silica%20fibre%20thermoluminescence.pdf
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spelling my.iium.irep.553622019-01-24T03:09:02Z http://irep.iium.edu.my/55362/ Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra Bradley, David A. Abdul Sani, Siti Fairus Ahmad Shaharuddin, Siti Shafiqah Collins, Sean M. Hugtenburg, Richard P. Abdul Rashid, Hairul Azhar Zulkepley, Nurul Najua Maah, Mohd Jamil QC Physics Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castration-resistant prostate cancer focuses on its favourable uptake in metabolically active bone metastases. Such treatment benefits from the high linear energy transfer (LET) and associated short path length (<100 µm) of the α-particles emitted by 223Ra and its decay progeny. In seeking to provide for in vitro dosimetry of the α-particles originating from the 223Ra decay series, investigation has been made of the TL yield of various forms of Ge-doped SiO2 fibres, including photonic crystal fibre (PCF) collapsed, PCF uncollapsed, flat and single-mode fibres. Irradiations of the fibres were performed at the UK National Physical Laboratory (NPL). Notable features are the considerable sensitivity of the dosimeters and an effective atomic number Zeff approaching that of bone, the glass fibres offering the added advantage of being able to be placed directly into liquid. The outcome of present research is expected to inform development of doped fibre dosimeters of versatile utility, including for applications as detailed herein. Elsevier B.V. 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55362/2/55362_Doped%20silica%20fibre%20thermoluminescence_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/55362/13/55362_Doped%20silica%20fibre%20thermoluminescence.pdf application/pdf en http://irep.iium.edu.my/55362/19/55362%20Doped%20silica%20fibre%20thermoluminescence%20measurements%20of%20radiation%20dose%20in%20the%20use%20of%20223Ra_wos.pdf Bradley, David A. and Abdul Sani, Siti Fairus and Ahmad Shaharuddin, Siti Shafiqah and Collins, Sean M. and Hugtenburg, Richard P. and Abdul Rashid, Hairul Azhar and Zulkepley, Nurul Najua and Maah, Mohd Jamil (2018) Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra. Applied Radiation and Isotopes, 138. pp. 65-72. ISSN 0969-8043 https://www.sciencedirect.com/science/article/pii/S0969804316311241#! 10.1016/j.apradiso.2017.04.019
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic QC Physics
spellingShingle QC Physics
Bradley, David A.
Abdul Sani, Siti Fairus
Ahmad Shaharuddin, Siti Shafiqah
Collins, Sean M.
Hugtenburg, Richard P.
Abdul Rashid, Hairul Azhar
Zulkepley, Nurul Najua
Maah, Mohd Jamil
Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra
description Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castration-resistant prostate cancer focuses on its favourable uptake in metabolically active bone metastases. Such treatment benefits from the high linear energy transfer (LET) and associated short path length (<100 µm) of the α-particles emitted by 223Ra and its decay progeny. In seeking to provide for in vitro dosimetry of the α-particles originating from the 223Ra decay series, investigation has been made of the TL yield of various forms of Ge-doped SiO2 fibres, including photonic crystal fibre (PCF) collapsed, PCF uncollapsed, flat and single-mode fibres. Irradiations of the fibres were performed at the UK National Physical Laboratory (NPL). Notable features are the considerable sensitivity of the dosimeters and an effective atomic number Zeff approaching that of bone, the glass fibres offering the added advantage of being able to be placed directly into liquid. The outcome of present research is expected to inform development of doped fibre dosimeters of versatile utility, including for applications as detailed herein.
format Article
author Bradley, David A.
Abdul Sani, Siti Fairus
Ahmad Shaharuddin, Siti Shafiqah
Collins, Sean M.
Hugtenburg, Richard P.
Abdul Rashid, Hairul Azhar
Zulkepley, Nurul Najua
Maah, Mohd Jamil
author_facet Bradley, David A.
Abdul Sani, Siti Fairus
Ahmad Shaharuddin, Siti Shafiqah
Collins, Sean M.
Hugtenburg, Richard P.
Abdul Rashid, Hairul Azhar
Zulkepley, Nurul Najua
Maah, Mohd Jamil
author_sort Bradley, David A.
title Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra
title_short Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra
title_full Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra
title_fullStr Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra
title_full_unstemmed Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223Ra
title_sort doped silica fibre thermoluminescence measurements of radiation dose in the use of 223ra
publisher Elsevier B.V.
publishDate 2018
url http://irep.iium.edu.my/55362/2/55362_Doped%20silica%20fibre%20thermoluminescence_SCOPUS.pdf
http://irep.iium.edu.my/55362/13/55362_Doped%20silica%20fibre%20thermoluminescence.pdf
http://irep.iium.edu.my/55362/19/55362%20Doped%20silica%20fibre%20thermoluminescence%20measurements%20of%20radiation%20dose%20in%20the%20use%20of%20223Ra_wos.pdf
http://irep.iium.edu.my/55362/
https://www.sciencedirect.com/science/article/pii/S0969804316311241#!
_version_ 1643618763968348160
score 13.211869

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