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Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric...

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Main Authors: Mehde, Atheer Awad, Yusof, Faridah, Mehdi, Wesen Adel, Ahmed Raus, Raha, Othman Farhan, Layla, Zainulabdeen, Jwan Abdulmohsin, Zainal Abidin, Zaima Azira, Ghazali, Hamid, Abd Rahman, Azlina
Format: Article
Language:English
English
Published: Elsevier BV 2016
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/54726/13/54726_Serum%20E3%20SUMO-protein.pdf
http://irep.iium.edu.my/54726/14/54726_Serum%20E3%20SUMO-protein_SCOPUS.pdf
http://irep.iium.edu.my/54726/
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spelling my.iium.irep.547262017-02-21T07:51:55Z http://irep.iium.edu.my/54726/ Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients Mehde, Atheer Awad Yusof, Faridah Mehdi, Wesen Adel Ahmed Raus, Raha Othman Farhan, Layla Zainulabdeen, Jwan Abdulmohsin Zainal Abidin, Zaima Azira Ghazali, Hamid Abd Rahman, Azlina R Medicine (General) Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric method was used to detect blood urea, creatinine, uric acid, protein, albumin, total antioxidant status, total oxidant status, peroxynitrite, nitric oxide and oxidative stress index. Glutathione, NSMCE2 and superoxide dismutase were measured by ELISA. Results: A significant increase in level of peroxynitrite, total oxidant status, NSMCE2 and oxidative stress index in patients was observed, while total antioxidant status and glutathione were significantly decreased. Conclusions: The study concluded that serum NSMCE2 significantly correlated with peroxynitrite and oxidative stress in patients with nephrolithiasis. Elsevier BV 2016-12-10 Article REM application/pdf en http://irep.iium.edu.my/54726/13/54726_Serum%20E3%20SUMO-protein.pdf application/pdf en http://irep.iium.edu.my/54726/14/54726_Serum%20E3%20SUMO-protein_SCOPUS.pdf Mehde, Atheer Awad and Yusof, Faridah and Mehdi, Wesen Adel and Ahmed Raus, Raha and Othman Farhan, Layla and Zainulabdeen, Jwan Abdulmohsin and Zainal Abidin, Zaima Azira and Ghazali, Hamid and Abd Rahman, Azlina (2016) Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients. Asian Pacific Journal of Tropical Biomedicine, 7 (3). pp. 249-252. ISSN 2221-1691 http://ac.els-cdn.com/S2221169116302192/1-s2.0-S2221169116302192-main.pdf?_tid=f6f2e420-f808-11e6-9647-00000aab0f6c&acdnat=1487662986_f0120fdce9a679cc59600706bf5d349f 10.1016/j.apjtb.2016.12.008
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mehde, Atheer Awad
Yusof, Faridah
Mehdi, Wesen Adel
Ahmed Raus, Raha
Othman Farhan, Layla
Zainulabdeen, Jwan Abdulmohsin
Zainal Abidin, Zaima Azira
Ghazali, Hamid
Abd Rahman, Azlina
Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
description Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric method was used to detect blood urea, creatinine, uric acid, protein, albumin, total antioxidant status, total oxidant status, peroxynitrite, nitric oxide and oxidative stress index. Glutathione, NSMCE2 and superoxide dismutase were measured by ELISA. Results: A significant increase in level of peroxynitrite, total oxidant status, NSMCE2 and oxidative stress index in patients was observed, while total antioxidant status and glutathione were significantly decreased. Conclusions: The study concluded that serum NSMCE2 significantly correlated with peroxynitrite and oxidative stress in patients with nephrolithiasis.
format Article
author Mehde, Atheer Awad
Yusof, Faridah
Mehdi, Wesen Adel
Ahmed Raus, Raha
Othman Farhan, Layla
Zainulabdeen, Jwan Abdulmohsin
Zainal Abidin, Zaima Azira
Ghazali, Hamid
Abd Rahman, Azlina
author_facet Mehde, Atheer Awad
Yusof, Faridah
Mehdi, Wesen Adel
Ahmed Raus, Raha
Othman Farhan, Layla
Zainulabdeen, Jwan Abdulmohsin
Zainal Abidin, Zaima Azira
Ghazali, Hamid
Abd Rahman, Azlina
author_sort Mehde, Atheer Awad
title Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
title_short Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
title_full Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
title_fullStr Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
title_full_unstemmed Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
title_sort serum e3 sumo-protein ligase nse2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
publisher Elsevier BV
publishDate 2016
url http://irep.iium.edu.my/54726/13/54726_Serum%20E3%20SUMO-protein.pdf
http://irep.iium.edu.my/54726/14/54726_Serum%20E3%20SUMO-protein_SCOPUS.pdf
http://irep.iium.edu.my/54726/
http://ac.els-cdn.com/S2221169116302192/1-s2.0-S2221169116302192-main.pdf?_tid=f6f2e420-f808-11e6-9647-00000aab0f6c&acdnat=1487662986_f0120fdce9a679cc59600706bf5d349f
_version_ 1643614604844072960
score 13.222552

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