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Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger

The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EP...

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Main Authors: Omar, Muhammad Nor, Hasali, Nor Hazwani, Yarmo, Mohd Ambar
Format: Article
Language:English
English
English
Published: Oriental Scientific Publishing Company 2016
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/54229/1/PROF%20NO%20OJC_Vol32_No5_p_2731-2734-2.pdf
http://irep.iium.edu.my/54229/7/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_WOS.pdf
http://irep.iium.edu.my/54229/8/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_SCOPUS.pdf
http://irep.iium.edu.my/54229/
http://www.orientjchem.org/vol32no5/cytotoxicity-activity-of-biotransformedethyl-p-methoxycinnamate-by-aspergillusniger/
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spelling my.iium.irep.542292017-11-21T09:17:00Z http://irep.iium.edu.my/54229/ Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger Omar, Muhammad Nor Hasali, Nor Hazwani Yarmo, Mohd Ambar QD Chemistry The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 μg/mL where percentage of cell viability was 9.87 %, while IC50 was 340 μg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC). Oriental Scientific Publishing Company 2016-10 Article REM application/pdf en http://irep.iium.edu.my/54229/1/PROF%20NO%20OJC_Vol32_No5_p_2731-2734-2.pdf application/pdf en http://irep.iium.edu.my/54229/7/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_WOS.pdf application/pdf en http://irep.iium.edu.my/54229/8/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_SCOPUS.pdf Omar, Muhammad Nor and Hasali, Nor Hazwani and Yarmo, Mohd Ambar (2016) Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger. Oriental Journal of Chemistry, 32 (5). pp. 2732-2734. ISSN 0970-020X http://www.orientjchem.org/vol32no5/cytotoxicity-activity-of-biotransformedethyl-p-methoxycinnamate-by-aspergillusniger/ 10.13005/ojc/320547
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic QD Chemistry
spellingShingle QD Chemistry
Omar, Muhammad Nor
Hasali, Nor Hazwani
Yarmo, Mohd Ambar
Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
description The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 μg/mL where percentage of cell viability was 9.87 %, while IC50 was 340 μg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC).
format Article
author Omar, Muhammad Nor
Hasali, Nor Hazwani
Yarmo, Mohd Ambar
author_facet Omar, Muhammad Nor
Hasali, Nor Hazwani
Yarmo, Mohd Ambar
author_sort Omar, Muhammad Nor
title Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_short Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_full Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_fullStr Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_full_unstemmed Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_sort cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by aspergillus niger
publisher Oriental Scientific Publishing Company
publishDate 2016
url http://irep.iium.edu.my/54229/1/PROF%20NO%20OJC_Vol32_No5_p_2731-2734-2.pdf
http://irep.iium.edu.my/54229/7/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_WOS.pdf
http://irep.iium.edu.my/54229/8/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_SCOPUS.pdf
http://irep.iium.edu.my/54229/
http://www.orientjchem.org/vol32no5/cytotoxicity-activity-of-biotransformedethyl-p-methoxycinnamate-by-aspergillusniger/
_version_ 1643614509096501248
score 13.211869

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