Cover Image

Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries

Background In developing countries such as Malaysia, the primary mode for revascularization is via thrombolytic therapy. This is only effective when instituted within a small time window and pre-hospital delay is a major concern. In a region where the mean house-to-door times can be as long as 8.5...

Full description

Saved in:
Bibliographic Details
Main Authors: SMS, Azarisman, Ngow, Harris Abdullah, PA, Melor, Ab Rahman, Jamalludin, Ahmad, Fauzi@Fauri, S., Sapari, K., Khairi, S., Noorfaizan, Oteh, Maskon
Format: Article
Language:English
Published: Springer New York LLC 2008
Subjects:
RC Internal medicine
Online Access:http://irep.iium.edu.my/5251/1/Combined_Circulation_Abstracts%5B1%5D.pdf
http://irep.iium.edu.my/5251/
http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=4&SID=T2ADnb8FamD8DhD@H8j&page=1&doc=1
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.5251
record_format dspace
spelling my.iium.irep.52512016-03-10T04:02:14Z http://irep.iium.edu.my/5251/ Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries SMS, Azarisman Ngow, Harris Abdullah PA, Melor Ab Rahman, Jamalludin Ahmad, Fauzi@Fauri S., Sapari K., Khairi S., Noorfaizan Oteh, Maskon RC Internal medicine Background In developing countries such as Malaysia, the primary mode for revascularization is via thrombolytic therapy. This is only effective when instituted within a small time window and pre-hospital delay is a major concern. In a region where the mean house-to-door times can be as long as 8.5 hours, there is an urgent need to reduce the door-to-needle times. Methods Emergency-based thrombolysis was initiated at Hospital Tengku Ampuan Afzan Kuantan, a 600-bed regional hospital in Malaysia. One hundred and thirty three patients with acute ST elevation myocardial infarction patients were screened. 39 patients were recruited in the 4 months prior to the implementation date and 94 patients were recruited after. The mean house-to-door, door-to-needle times were recorded. Results The majority of patients were male 88.7%, with a mean age of 56.4 � 10.3 years. The median presentation time (house-to-door) was 117.50 minutes before and 136.00 minutes after (p � 0.213, Mann- Whitney U) minutes. The median door-to-needle time was 100.00 minutes before and 50.00 minutes after (p � 0.031). The mortality rates were 12.8% before and 11.70% (p�0.87, Fisher exact test) after mplementation of Emergency-based thrombolysis. Conclusion Implementation of Emergency-based thrombolysis has markedly improved the door-to-needle times and resulted in a trend towards reduced mortality rates in acute ST-elevation myocardial infarction. Springer New York LLC 2008-05-13 Article REM application/pdf en http://irep.iium.edu.my/5251/1/Combined_Circulation_Abstracts%5B1%5D.pdf SMS, Azarisman and Ngow, Harris Abdullah and PA, Melor and Ab Rahman, Jamalludin and Ahmad, Fauzi@Fauri and S., Sapari and K., Khairi and S., Noorfaizan and Oteh, Maskon (2008) Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries. Journal of Thrombosis and Thrombolysis : a journal for translation, application and therapeutics, 118 (12). E206-E206. ISSN 0929-5305 http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=4&SID=T2ADnb8FamD8DhD@H8j&page=1&doc=1
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
SMS, Azarisman
Ngow, Harris Abdullah
PA, Melor
Ab Rahman, Jamalludin
Ahmad, Fauzi@Fauri
S., Sapari
K., Khairi
S., Noorfaizan
Oteh, Maskon
Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries
description Background In developing countries such as Malaysia, the primary mode for revascularization is via thrombolytic therapy. This is only effective when instituted within a small time window and pre-hospital delay is a major concern. In a region where the mean house-to-door times can be as long as 8.5 hours, there is an urgent need to reduce the door-to-needle times. Methods Emergency-based thrombolysis was initiated at Hospital Tengku Ampuan Afzan Kuantan, a 600-bed regional hospital in Malaysia. One hundred and thirty three patients with acute ST elevation myocardial infarction patients were screened. 39 patients were recruited in the 4 months prior to the implementation date and 94 patients were recruited after. The mean house-to-door, door-to-needle times were recorded. Results The majority of patients were male 88.7%, with a mean age of 56.4 � 10.3 years. The median presentation time (house-to-door) was 117.50 minutes before and 136.00 minutes after (p � 0.213, Mann- Whitney U) minutes. The median door-to-needle time was 100.00 minutes before and 50.00 minutes after (p � 0.031). The mortality rates were 12.8% before and 11.70% (p�0.87, Fisher exact test) after mplementation of Emergency-based thrombolysis. Conclusion Implementation of Emergency-based thrombolysis has markedly improved the door-to-needle times and resulted in a trend towards reduced mortality rates in acute ST-elevation myocardial infarction.
format Article
author SMS, Azarisman
Ngow, Harris Abdullah
PA, Melor
Ab Rahman, Jamalludin
Ahmad, Fauzi@Fauri
S., Sapari
K., Khairi
S., Noorfaizan
Oteh, Maskon
author_facet SMS, Azarisman
Ngow, Harris Abdullah
PA, Melor
Ab Rahman, Jamalludin
Ahmad, Fauzi@Fauri
S., Sapari
K., Khairi
S., Noorfaizan
Oteh, Maskon
author_sort SMS, Azarisman
title Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries
title_short Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries
title_full Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries
title_fullStr Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries
title_full_unstemmed Implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries
title_sort implementation of emergency-based thrombolysis : an achievable option for rural hospitals in developing countries
publisher Springer New York LLC
publishDate 2008
url http://irep.iium.edu.my/5251/1/Combined_Circulation_Abstracts%5B1%5D.pdf
http://irep.iium.edu.my/5251/
http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=4&SID=T2ADnb8FamD8DhD@H8j&page=1&doc=1
_version_ 1643605500652158976
score 13.211869

Similar Items