Staff View: Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia

Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia

Epigenetic is a mutual interaction between the gene and environment. It forms the basis of many diseases including Schizophrenia. Brain derived neurotrophic factors (BDNF) contributes to neurodeveloment hypothesis of Schizophrenia since its function is to facilitate neuronal signaling and survival....

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Main Authors:	Abd. Rahim, Nour El Huda, Rahim, Mohd Nabil Fikri, Ku Zaifah, Norsidah, Mohd Noor, Hanisah, Abdullah, Kartini, A.Talib, Norlelawati
Format:	Conference or Workshop Item
Language:	English English
Published:	2016
Subjects:	R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/52018/1/Poster%20Huda%20MSBMB%20print.pdf http://irep.iium.edu.my/52018/7/52018_abstract.pdf http://irep.iium.edu.my/52018/
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spelling	my.iium.irep.520182017-08-01T08:27:04Z http://irep.iium.edu.my/52018/ Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia Abd. Rahim, Nour El Huda Rahim, Mohd Nabil Fikri Ku Zaifah, Norsidah Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Epigenetic is a mutual interaction between the gene and environment. It forms the basis of many diseases including Schizophrenia. Brain derived neurotrophic factors (BDNF) contributes to neurodeveloment hypothesis of Schizophrenia since its function is to facilitate neuronal signaling and survival. Hypermethylated effect of BDNF gene may cause reduction in BDNF transcription. Thus, contribute to pathophysiology of Schizophrenia. The objective of this study is to assess the relationship of BDNF gene DNA methylation in Schizophrenia. A total of 240 participants (118 Schizophrenia and 122 healthy controls) were recruited. Genomic DNA was extracted from peripheral blood and bisulfite treated. The Methylight Taqman analysis method was adopted for the quantitation of the methylation level. Sociodemographic variables were gathered through interview and the review of the medical records. There was no significant difference of DNA methylation between the two study groups. However, among males, the DNA methylation level of BDNF was significantly increased as compared to the healthy control (p = 0.016). Further analysis among Schizophrenia showed significant inverse correlation between the level of methylation and age of the patients (r=-0.089, p=0.001) and the number of years of having the disease (r=-0.120, p=0.000). Otherwise, there were no correlation between BDNF DNA methylation level with body mass index, age of diagnosis, educational status and smoking status. Methylation status is related to Schizophrenia among males. However this sex specific tendency may require further evaluation. The reduction of methylation status with aging and duration of illness follows the typical degradation of methylation observed in aging. 2016-08-17 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/52018/1/Poster%20Huda%20MSBMB%20print.pdf application/pdf en http://irep.iium.edu.my/52018/7/52018_abstract.pdf Abd. Rahim, Nour El Huda and Rahim, Mohd Nabil Fikri and Ku Zaifah, Norsidah and Mohd Noor, Hanisah and Abdullah, Kartini and A.Talib, Norlelawati (2016) Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia. In: 41st Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology (MSBMB 2016), 17th-18th Aug. 2016, Kuala Lumpur. (Unpublished)
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Abd. Rahim, Nour El Huda Rahim, Mohd Nabil Fikri Ku Zaifah, Norsidah Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia
description	Epigenetic is a mutual interaction between the gene and environment. It forms the basis of many diseases including Schizophrenia. Brain derived neurotrophic factors (BDNF) contributes to neurodeveloment hypothesis of Schizophrenia since its function is to facilitate neuronal signaling and survival. Hypermethylated effect of BDNF gene may cause reduction in BDNF transcription. Thus, contribute to pathophysiology of Schizophrenia. The objective of this study is to assess the relationship of BDNF gene DNA methylation in Schizophrenia. A total of 240 participants (118 Schizophrenia and 122 healthy controls) were recruited. Genomic DNA was extracted from peripheral blood and bisulfite treated. The Methylight Taqman analysis method was adopted for the quantitation of the methylation level. Sociodemographic variables were gathered through interview and the review of the medical records. There was no significant difference of DNA methylation between the two study groups. However, among males, the DNA methylation level of BDNF was significantly increased as compared to the healthy control (p = 0.016). Further analysis among Schizophrenia showed significant inverse correlation between the level of methylation and age of the patients (r=-0.089, p=0.001) and the number of years of having the disease (r=-0.120, p=0.000). Otherwise, there were no correlation between BDNF DNA methylation level with body mass index, age of diagnosis, educational status and smoking status. Methylation status is related to Schizophrenia among males. However this sex specific tendency may require further evaluation. The reduction of methylation status with aging and duration of illness follows the typical degradation of methylation observed in aging.
format	Conference or Workshop Item
author	Abd. Rahim, Nour El Huda Rahim, Mohd Nabil Fikri Ku Zaifah, Norsidah Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati
author_facet	Abd. Rahim, Nour El Huda Rahim, Mohd Nabil Fikri Ku Zaifah, Norsidah Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati
author_sort	Abd. Rahim, Nour El Huda
title	Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia
title_short	Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia
title_full	Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia
title_fullStr	Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia
title_full_unstemmed	Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia
title_sort	relationship of brain derived neurotrophic factor (bdnf) dna methylation with schizophrenia
publishDate	2016
url	http://irep.iium.edu.my/52018/1/Poster%20Huda%20MSBMB%20print.pdf http://irep.iium.edu.my/52018/7/52018_abstract.pdf http://irep.iium.edu.my/52018/
_version_	1643614086754205696
score	13.211869

Relationship of brain derived neurotrophic factor (BDNF) DNA methylation with schizophrenia

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