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Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model

Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with h...

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Main Authors: Abdul Rahim, Roslina, Badaruddin, Muhammad Taufiq, Ahmed, Qamar Uddin, Muhammad, Siti Aeshah @ Naznin
Format: Conference or Workshop Item
Language:English
Published: 2016
Subjects:
QP Physiology
RB Pathology
RC Internal medicine
Online Access:http://irep.iium.edu.my/51856/40/51856.pdf
http://irep.iium.edu.my/51856/
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spelling my.iium.irep.518562022-04-07T01:57:01Z http://irep.iium.edu.my/51856/ Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aeshah @ Naznin QP Physiology RB Pathology RC Internal medicine Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD. 2016-08 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/51856/40/51856.pdf Abdul Rahim, Roslina and Badaruddin, Muhammad Taufiq and Ahmed, Qamar Uddin and Muhammad, Siti Aeshah @ Naznin (2016) Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model. In: Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016, 3rd-5th August 2016, Kuantan, Pahang, Malaysia. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QP Physiology
RB Pathology
RC Internal medicine
spellingShingle QP Physiology
RB Pathology
RC Internal medicine
Abdul Rahim, Roslina
Badaruddin, Muhammad Taufiq
Ahmed, Qamar Uddin
Muhammad, Siti Aeshah @ Naznin
Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
description Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD.
format Conference or Workshop Item
author Abdul Rahim, Roslina
Badaruddin, Muhammad Taufiq
Ahmed, Qamar Uddin
Muhammad, Siti Aeshah @ Naznin
author_facet Abdul Rahim, Roslina
Badaruddin, Muhammad Taufiq
Ahmed, Qamar Uddin
Muhammad, Siti Aeshah @ Naznin
author_sort Abdul Rahim, Roslina
title Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_short Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_full Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_fullStr Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_full_unstemmed Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
title_sort nigella sativa oil extracts improves dyslipidaemia in high fat diet (hfd) animal model
publishDate 2016
url http://irep.iium.edu.my/51856/40/51856.pdf
http://irep.iium.edu.my/51856/
_version_ 1729702897048879104
score 13.211869

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