Electrochemical characterization of polylactic acid-block-poly(2-vinylpyridine)/gold nanoparticle (aunp) composites for glucose biosensor development
Nanocomposites that consist of diblock copolymer (BCP) and gold nanoparticles (AuNPs) can be applied as a suitable matrix to immobilize enzymes or other molecules based on the well-defined core/shell nanostructures of these composites. In this research, polylactic acid-block-poly(2-vinylpyridine)...
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| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Kulliyah of Engineering, International Islamic University Malaysia
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/51784/1/51784.pdf http://irep.iium.edu.my/51784/ http://www.iium.edu.my/icbioe/2016/ |
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| Summary: | Nanocomposites that consist of diblock copolymer (BCP) and gold nanoparticles (AuNPs) can be applied as a
suitable matrix to immobilize enzymes or other molecules based on the well-defined core/shell nanostructures
of these composites. In this research, polylactic acid-block-poly(2-vinylpyridine) (PLA-b-P2VP)/hydrogen
tetrachloroaurate(III) hydrate (HAuCl4.3H2O) composites were hybridized and then reduced in
dichloromethane (DCM) solution. The hybridizations between gold precursors and the P2VP domain were
prepared with different ratios of gold to P2VP block (1:1, 1:5, 1:10, 5:1, 10:1) by taking advantage of the
association between the long-pair nitrogen of the pyridine group of P2VP. The reduction of the Au3+/PLA-bP2VP
composite was accomplished by hydrazine solution in order to get gold nanoparticle/PLA-b-P2VP
composites, visually confirmed by a direct color change from bright yellow to purple. In this work,
ultraviolet–visible (UV-vis) spectroscopy and Fourier transform infrared spectroscopy (FTIR) were used to
confirm the association between gold precursors and pyridine groups as well as the synthesis of gold
nanoparticles. Furthermore, the electrochemical properties of gold nanoparticle/BCP composites with
different ratios were obtained via cyclic voltammetry measurement. This composite has high potential to be
used in the development of a glucose biosensor. |
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