Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group N...
保存先:
| 主要な著者: | , , , , , |
|---|---|
| フォーマット: | 論文 |
| 言語: | English English |
| 出版事項: |
The Spanish Society of Anatomy
2016
|
| 主題: | |
| オンライン･アクセス: | http://irep.iium.edu.my/50698/1/Article_2016.pdf http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf http://irep.iium.edu.my/50698/ http://eurjanat.com/data/pdf/eja.150350ia.pdf |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|
| id |
my.iium.irep.50698 |
|---|---|
| record_format |
dspace |
| spelling |
my.iium.irep.506982017-04-04T02:16:56Z http://irep.iium.edu.my/50698/ Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah R Medicine (General) RM Therapeutics. Pharmacology The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure. The Spanish Society of Anatomy 2016-04 Article REM application/pdf en http://irep.iium.edu.my/50698/1/Article_2016.pdf application/pdf en http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf Al-Jaufi, Fakhria and Al-Ani, Imad M and Saxena, Anil Kumar and Talib, Norlelawati A. and H. Mokhtar, Rafidah and Ku-Zaifah, Norsidah (2016) Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study. European Journal of Anatomy, 20 (2). pp. 131-136. ISSN 1136-4890 http://eurjanat.com/data/pdf/eja.150350ia.pdf |
| institution |
Universiti Islam Antarabangsa Malaysia |
| building |
IIUM Library |
| collection |
Institutional Repository |
| continent |
Asia |
| country |
Malaysia |
| content_provider |
International Islamic University Malaysia |
| content_source |
IIUM Repository (IREP) |
| url_provider |
http://irep.iium.edu.my/ |
| language |
English English |
| topic |
R Medicine (General) RM Therapeutics. Pharmacology |
| spellingShingle |
R Medicine (General) RM Therapeutics. Pharmacology Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| description |
The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure. |
| format |
Article |
| author |
Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah |
| author_facet |
Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah |
| author_sort |
Al-Jaufi, Fakhria |
| title |
Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_short |
Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_full |
Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_fullStr |
Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_full_unstemmed |
Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_sort |
assessment of anti-atherosclerotic effect of eurycoma longifolia extract on high-fat diet model in rats. i: histological study |
| publisher |
The Spanish Society of Anatomy |
| publishDate |
2016 |
| url |
http://irep.iium.edu.my/50698/1/Article_2016.pdf http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf http://irep.iium.edu.my/50698/ http://eurjanat.com/data/pdf/eja.150350ia.pdf |
| _version_ |
1643613790848155648 |
| score |
13.251813 |