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Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines

Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceratio...

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Main Authors: Hamidon, Hanisuhana, Bakhtiar, M. Taher, Md. Jaffri, Juliana, Tg Zakaria, Tg Muhammad Faris Syafiq, Wan Sulaiman, Wan Mohd Azizi, Darnis, Deny Susanti, Ichwan, Solachuddin Jauhari Arief, Zakaria, Zainul Amiruddin
Format: Article
Language:English
English
Published: Directorate of Research and Public Services Universitas Indonesia 2016
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/50327/1/Makara-5599-10849-1-PB.pdf
http://irep.iium.edu.my/50327/4/50327_Cytotoxic%20and%20anti-inflammatory_wos.pdf
http://irep.iium.edu.my/50327/
http://journal.ui.ac.id/index.php/health/article/view/5599/3624
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spelling my.iium.irep.503272022-12-09T02:32:04Z http://irep.iium.edu.my/50327/ Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines Hamidon, Hanisuhana Bakhtiar, M. Taher Md. Jaffri, Juliana Tg Zakaria, Tg Muhammad Faris Syafiq Wan Sulaiman, Wan Mohd Azizi Darnis, Deny Susanti Ichwan, Solachuddin Jauhari Arief Zakaria, Zainul Amiruddin RS Pharmacy and materia medica Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusion: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation. Directorate of Research and Public Services Universitas Indonesia 2016-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50327/1/Makara-5599-10849-1-PB.pdf application/pdf en http://irep.iium.edu.my/50327/4/50327_Cytotoxic%20and%20anti-inflammatory_wos.pdf Hamidon, Hanisuhana and Bakhtiar, M. Taher and Md. Jaffri, Juliana and Tg Zakaria, Tg Muhammad Faris Syafiq and Wan Sulaiman, Wan Mohd Azizi and Darnis, Deny Susanti and Ichwan, Solachuddin Jauhari Arief and Zakaria, Zainul Amiruddin (2016) Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines. Makara Journal of Health Research, 20 (1). pp. 11-17. ISSN 2356-3664 E-ISSN 2356-3656 http://journal.ui.ac.id/index.php/health/article/view/5599/3624 10.7454/msk.v20i1.5599
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Hamidon, Hanisuhana
Bakhtiar, M. Taher
Md. Jaffri, Juliana
Tg Zakaria, Tg Muhammad Faris Syafiq
Wan Sulaiman, Wan Mohd Azizi
Darnis, Deny Susanti
Ichwan, Solachuddin Jauhari Arief
Zakaria, Zainul Amiruddin
Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
description Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusion: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.
format Article
author Hamidon, Hanisuhana
Bakhtiar, M. Taher
Md. Jaffri, Juliana
Tg Zakaria, Tg Muhammad Faris Syafiq
Wan Sulaiman, Wan Mohd Azizi
Darnis, Deny Susanti
Ichwan, Solachuddin Jauhari Arief
Zakaria, Zainul Amiruddin
author_facet Hamidon, Hanisuhana
Bakhtiar, M. Taher
Md. Jaffri, Juliana
Tg Zakaria, Tg Muhammad Faris Syafiq
Wan Sulaiman, Wan Mohd Azizi
Darnis, Deny Susanti
Ichwan, Solachuddin Jauhari Arief
Zakaria, Zainul Amiruddin
author_sort Hamidon, Hanisuhana
title Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_short Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_full Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_fullStr Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_full_unstemmed Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_sort cytotoxic and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
publisher Directorate of Research and Public Services Universitas Indonesia
publishDate 2016
url http://irep.iium.edu.my/50327/1/Makara-5599-10849-1-PB.pdf
http://irep.iium.edu.my/50327/4/50327_Cytotoxic%20and%20anti-inflammatory_wos.pdf
http://irep.iium.edu.my/50327/
http://journal.ui.ac.id/index.php/health/article/view/5599/3624
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score 13.211869

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