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A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis

Objectives: This study aims to identify the characteristics of scleroderma patients in terms of sociodemographic and clinical characteristics and severity of lung fibrosis and pulmonary hypertension and to show the association between European Scleroderma Study Group (EScSG) scoring and severity of...

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Main Authors: Wan Ali, Wan Ahmad Syahril Rozli, Mohamed Said, Mohd Shahrir, Shaharir , Syahrul Sazliyana, Ban , Andrea Yu Lin, Hussain, Rizuana Iqbal, Rosman, Azmillah
Format: Article
Language:English
Published: Turkish League Against Rheumatism 2015
Subjects:
R Medicine (General)
RC Internal medicine
Online Access:http://irep.iium.edu.my/48264/1/2015-30-4-311-318-eng.pdf
http://irep.iium.edu.my/48264/
http://www.archivesofrheumatology.org/abstract/744
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spelling my.iium.irep.482642018-02-07T07:10:32Z http://irep.iium.edu.my/48264/ A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis Wan Ali, Wan Ahmad Syahril Rozli Mohamed Said, Mohd Shahrir Shaharir , Syahrul Sazliyana Ban , Andrea Yu Lin Hussain, Rizuana Iqbal Rosman, Azmillah R Medicine (General) RC Internal medicine Objectives: This study aims to identify the characteristics of scleroderma patients in terms of sociodemographic and clinical characteristics and severity of lung fibrosis and pulmonary hypertension and to show the association between European Scleroderma Study Group (EScSG) scoring and severity of pulmonary hypertension and lung fibrosis. Patients and methods: This two center cross-sectional study included 43 scleroderma patients (4 males, 39 females; mean age 52 years; range 42 to 59 years) under clinical follow-up. Patients’ sociodemographic data were recorded. Median duration of illness was 10.0 years. All patients underwent blood tests, echocardiogram, full lung function test, six-minute walking test, and high resolution computed tomography of the thorax. Pulmonary hypertension was defined by echocardiogram as systolic pulmonary pressure >36 mmHg. Results: Limited systemic sclerosis was the predominant type (74.7%). Majority of high resolution computed tomography findings showed lung fibrosis with ground glass opacities (74.4%). Pulmonary hypertension was predominantly mild (31.7%), lung function test showed 36.1% restrictive lung disease, and a reduced diffusing capacity of the lungs for carbon monoxide (median 13.85) with reduced six-minute walking test distance (median 300.0 meters). Health Assessment Questionnaire scoring was predominantly in the mild to moderate disability group (median score of 0.5). Five patients (13.9%) had active disease based on the EScSG scoring. There were no significant associations between EScSG scoring and other clinical parameters. Conclusion: In our study, we found that scleroderma was predominant among females and the major type was limited systemic sclerosis. The lung function test revealed a sub-normal diffusing carbon monoxide with a reduced six-minute walking distance. Turkish League Against Rheumatism 2015 Article REM application/pdf en http://irep.iium.edu.my/48264/1/2015-30-4-311-318-eng.pdf Wan Ali, Wan Ahmad Syahril Rozli and Mohamed Said, Mohd Shahrir and Shaharir , Syahrul Sazliyana and Ban , Andrea Yu Lin and Hussain, Rizuana Iqbal and Rosman, Azmillah (2015) A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis. Archives of Rheumatology, 30 (4). pp. 311-318. ISSN 2148-5046 http://www.archivesofrheumatology.org/abstract/744 10.5606/ArchRheumatol.2015.5593
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RC Internal medicine
spellingShingle R Medicine (General)
RC Internal medicine
Wan Ali, Wan Ahmad Syahril Rozli
Mohamed Said, Mohd Shahrir
Shaharir , Syahrul Sazliyana
Ban , Andrea Yu Lin
Hussain, Rizuana Iqbal
Rosman, Azmillah
A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
description Objectives: This study aims to identify the characteristics of scleroderma patients in terms of sociodemographic and clinical characteristics and severity of lung fibrosis and pulmonary hypertension and to show the association between European Scleroderma Study Group (EScSG) scoring and severity of pulmonary hypertension and lung fibrosis. Patients and methods: This two center cross-sectional study included 43 scleroderma patients (4 males, 39 females; mean age 52 years; range 42 to 59 years) under clinical follow-up. Patients’ sociodemographic data were recorded. Median duration of illness was 10.0 years. All patients underwent blood tests, echocardiogram, full lung function test, six-minute walking test, and high resolution computed tomography of the thorax. Pulmonary hypertension was defined by echocardiogram as systolic pulmonary pressure >36 mmHg. Results: Limited systemic sclerosis was the predominant type (74.7%). Majority of high resolution computed tomography findings showed lung fibrosis with ground glass opacities (74.4%). Pulmonary hypertension was predominantly mild (31.7%), lung function test showed 36.1% restrictive lung disease, and a reduced diffusing capacity of the lungs for carbon monoxide (median 13.85) with reduced six-minute walking test distance (median 300.0 meters). Health Assessment Questionnaire scoring was predominantly in the mild to moderate disability group (median score of 0.5). Five patients (13.9%) had active disease based on the EScSG scoring. There were no significant associations between EScSG scoring and other clinical parameters. Conclusion: In our study, we found that scleroderma was predominant among females and the major type was limited systemic sclerosis. The lung function test revealed a sub-normal diffusing carbon monoxide with a reduced six-minute walking distance.
format Article
author Wan Ali, Wan Ahmad Syahril Rozli
Mohamed Said, Mohd Shahrir
Shaharir , Syahrul Sazliyana
Ban , Andrea Yu Lin
Hussain, Rizuana Iqbal
Rosman, Azmillah
author_facet Wan Ali, Wan Ahmad Syahril Rozli
Mohamed Said, Mohd Shahrir
Shaharir , Syahrul Sazliyana
Ban , Andrea Yu Lin
Hussain, Rizuana Iqbal
Rosman, Azmillah
author_sort Wan Ali, Wan Ahmad Syahril Rozli
title A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
title_short A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
title_full A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
title_fullStr A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
title_full_unstemmed A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
title_sort cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
publisher Turkish League Against Rheumatism
publishDate 2015
url http://irep.iium.edu.my/48264/1/2015-30-4-311-318-eng.pdf
http://irep.iium.edu.my/48264/
http://www.archivesofrheumatology.org/abstract/744
_version_ 1643613334836084736
score 13.211869

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