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Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia

Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvem...

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Main Authors: Md Rosli, Ahmad Nabil, Subbiah, Rakesh, Maniam, T
Format: Article
Language:English
Published: ASEAN Federation of Psychiatry 2014
Subjects:
R Medicine (General)
RC Internal medicine
Online Access:http://irep.iium.edu.my/47979/1/CLOZAPINE_RE-CHALLENGE_WITH_LITHIUM.pdf
http://irep.iium.edu.my/47979/
http://www.aseanjournalofpsychiatry.org/index.php/aseanjournalofpsychiatry/article/view/191
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spelling my.iium.irep.47979 http://irep.iium.edu.my/47979/ Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia Md Rosli, Ahmad Nabil Subbiah, Rakesh Maniam, T R Medicine (General) RC Internal medicine Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely. Results: The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patient’s clinical condition also improved. Conclusion: Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed ASEAN Federation of Psychiatry 2014-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47979/1/CLOZAPINE_RE-CHALLENGE_WITH_LITHIUM.pdf Md Rosli, Ahmad Nabil and Subbiah, Rakesh and Maniam, T (2014) Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia. ASEAN Journal of Psychiatry, 15 (1). pp. 90-92. ISSN 2231-7791 (O), 1876-2018 (P) http://www.aseanjournalofpsychiatry.org/index.php/aseanjournalofpsychiatry/article/view/191
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RC Internal medicine
spellingShingle R Medicine (General)
RC Internal medicine
Md Rosli, Ahmad Nabil
Subbiah, Rakesh
Maniam, T
Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
description Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely. Results: The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patient’s clinical condition also improved. Conclusion: Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed
format Article
author Md Rosli, Ahmad Nabil
Subbiah, Rakesh
Maniam, T
author_facet Md Rosli, Ahmad Nabil
Subbiah, Rakesh
Maniam, T
author_sort Md Rosli, Ahmad Nabil
title Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_short Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_full Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_fullStr Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_full_unstemmed Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_sort clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
publisher ASEAN Federation of Psychiatry
publishDate 2014
url http://irep.iium.edu.my/47979/1/CLOZAPINE_RE-CHALLENGE_WITH_LITHIUM.pdf
http://irep.iium.edu.my/47979/
http://www.aseanjournalofpsychiatry.org/index.php/aseanjournalofpsychiatry/article/view/191
_version_ 1643616893589782528
score 13.211869

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