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The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model

Introduction: Conditioned Place Preference (CPP) continues to be one of the most popular models to study the dependence effects of substance abuse. This study is divided into three main phases which are pre-conditioning, conditioning and post-conditioning phases. It can be conducted using different...

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Main Authors: Abdul Basir, Siti Najihah, Suhaimi, Maryam Saadah, Syd Mohmad Faudzi, Syed Mohd Syahmi, Ridzwan, Irna Elina
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/45947/8/PPoint_UCSI_%28N%29.pdf
http://irep.iium.edu.my/45947/
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spelling my.iium.irep.459472018-01-03T06:51:32Z http://irep.iium.edu.my/45947/ The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model Abdul Basir, Siti Najihah Suhaimi, Maryam Saadah Syd Mohmad Faudzi, Syed Mohd Syahmi Ridzwan, Irna Elina RS Pharmacy and materia medica Introduction: Conditioned Place Preference (CPP) continues to be one of the most popular models to study the dependence effects of substance abuse. This study is divided into three main phases which are pre-conditioning, conditioning and post-conditioning phases. It can be conducted using different protocols which can be used to investigate the effects of drug dependence. Since there is not much study done to investigate the effects of duration of confinement, this study is conducted to figure out the effects of different duration of confinement towards intensity of morphine dependence. Methods: Using adult male Swiss albino mice, 12 mice were used for each group with different duration of confinement times, 40 to 60 minutes respectively. During conditioning phase, the mice received 7.5 mg/kg morphine and saline through intraperitoneal route on alternate day for 6 days. Result: Using unbiased method, it was found that both groups had significantly developed dependence (P<0.05, P<0.01). Later, a comparison between these groups had shown that the group of mice that underwent 60 minutes confinement time showed greater intensity of dependence than the other group, although the difference was not statistically significant. Interestingly, it was also noted that the number of mice that was excluded after post-conditioning test was higher in the group that underwent 40 minutes confinement cpmpared to the counterpart (n=5, n=2). Conclusion: These results proved that increasing in confinement time caused an increase in the intensity of morphine dependence in mice. Therefore, it is suggested that 60 minutes confinement time is more suitable for morphine to develop dependence in mice and to minimise subject elimination throughout a long cycle of CPP procedure, provided that other variables are maintained. 2015-10-10 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/45947/8/PPoint_UCSI_%28N%29.pdf Abdul Basir, Siti Najihah and Suhaimi, Maryam Saadah and Syd Mohmad Faudzi, Syed Mohd Syahmi and Ridzwan, Irna Elina (2015) The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model. In: Health and Pharmaceutical Sciences Undergraduate Research Symposium, 10th October, 2015, Le Quadri Ball Room, KL campus, North Wing, UCSI University, KL, Malaysia. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Abdul Basir, Siti Najihah
Suhaimi, Maryam Saadah
Syd Mohmad Faudzi, Syed Mohd Syahmi
Ridzwan, Irna Elina
The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model
description Introduction: Conditioned Place Preference (CPP) continues to be one of the most popular models to study the dependence effects of substance abuse. This study is divided into three main phases which are pre-conditioning, conditioning and post-conditioning phases. It can be conducted using different protocols which can be used to investigate the effects of drug dependence. Since there is not much study done to investigate the effects of duration of confinement, this study is conducted to figure out the effects of different duration of confinement towards intensity of morphine dependence. Methods: Using adult male Swiss albino mice, 12 mice were used for each group with different duration of confinement times, 40 to 60 minutes respectively. During conditioning phase, the mice received 7.5 mg/kg morphine and saline through intraperitoneal route on alternate day for 6 days. Result: Using unbiased method, it was found that both groups had significantly developed dependence (P<0.05, P<0.01). Later, a comparison between these groups had shown that the group of mice that underwent 60 minutes confinement time showed greater intensity of dependence than the other group, although the difference was not statistically significant. Interestingly, it was also noted that the number of mice that was excluded after post-conditioning test was higher in the group that underwent 40 minutes confinement cpmpared to the counterpart (n=5, n=2). Conclusion: These results proved that increasing in confinement time caused an increase in the intensity of morphine dependence in mice. Therefore, it is suggested that 60 minutes confinement time is more suitable for morphine to develop dependence in mice and to minimise subject elimination throughout a long cycle of CPP procedure, provided that other variables are maintained.
format Conference or Workshop Item
author Abdul Basir, Siti Najihah
Suhaimi, Maryam Saadah
Syd Mohmad Faudzi, Syed Mohd Syahmi
Ridzwan, Irna Elina
author_facet Abdul Basir, Siti Najihah
Suhaimi, Maryam Saadah
Syd Mohmad Faudzi, Syed Mohd Syahmi
Ridzwan, Irna Elina
author_sort Abdul Basir, Siti Najihah
title The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model
title_short The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model
title_full The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model
title_fullStr The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model
title_full_unstemmed The influence of duration of confinement towards morphine dependence intensity in conditioned place preference (CPP) model
title_sort influence of duration of confinement towards morphine dependence intensity in conditioned place preference (cpp) model
publishDate 2015
url http://irep.iium.edu.my/45947/8/PPoint_UCSI_%28N%29.pdf
http://irep.iium.edu.my/45947/
_version_ 1643612890304872448
score 13.211869

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