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Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats

Background: Current evidence indicates mixed findings with regard to the effects of low and high maternal dietary salt intake during pregnancy on the maternal blood pressure. Objective: This study investigates the effects of low and high maternal dietary salt intake on the systolic blood pressure...

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Main Authors: Mohd Noor, Noriah, Aminuddin, Niferiti, Tin, Myo Han, Mohd Rashid, Muhammad Hakimi, Abdul Razak, Tariq
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/45310/1/Noriah_et_al_2015.pdf
http://irep.iium.edu.my/45310/
http://icmh2015.usim.edu.my/
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spelling my.iium.irep.453102016-05-24T00:23:16Z http://irep.iium.edu.my/45310/ Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats Mohd Noor, Noriah Aminuddin, Niferiti Tin, Myo Han Mohd Rashid, Muhammad Hakimi Abdul Razak, Tariq R Medicine (General) Background: Current evidence indicates mixed findings with regard to the effects of low and high maternal dietary salt intake during pregnancy on the maternal blood pressure. Objective: This study investigates the effects of low and high maternal dietary salt intake on the systolic blood pressure (SBP) at third week of gestation as compared to pre-pregnancy SBP. Methodology: 30 female Sprague Dawley normotensive rats were randomly assigned into three groups based on maternal dietary salt concentration; low salt (0.145% NaCl, n=10), normal salt (1.0% NaCl, n =10) and high salt (3.0% NaCl, n=10). Food intake and maternal body weight were recorded. SBP (mmHg) and heart rate (HR) were measured during pre-pregnancy and at third week of pregnancy by using non-invasive tail cuff blood pressure monitoring device. Results: There were comparable pre-pregnancy body weight, mean daily food intake, HR and SBP (116.5± 1.54 vs. 118.07 ± 1.22 vs. 115.83 ± 1.76) among LSD, NSD and HSD dams respectively. There were no significant differences in maternal mean daily food intake throughout the pregnancy, body weight at third week of gestation, HR and SBP (113.67± 2.74 vs. 111.37 ± 1.84 vs. 113.93 ± 2.11) at third week of gestation among LSD, NSD and HSD dams respectively. Statistically significant difference in term of SBP between pre-pregnancy and third week of gestation was only seen in the NSD dams (118.07 ±1.22 vs. 111.37 ±1.84) (P<0.05). HR was comparable among the three dams. Conclusion: The SBP decreases in all maternal groups at third week of gestation. However, within group analysis revealed that only NSD dams has significantly lower SBP at third week of gestation as compared to pre- pregnancy SBP. The decrement of SBP is more pronounced in the NSD dams depicting the possibilities of aberration in the expected cardiovascular physiological changes in LSD and HSD dams. 2015 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/45310/1/Noriah_et_al_2015.pdf Mohd Noor, Noriah and Aminuddin, Niferiti and Tin, Myo Han and Mohd Rashid, Muhammad Hakimi and Abdul Razak, Tariq (2015) Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats. In: USIM International Conference on Medicine and Health, 17-18 Oct 2015, Nilai, Negeri Sembilan. http://icmh2015.usim.edu.my/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mohd Noor, Noriah
Aminuddin, Niferiti
Tin, Myo Han
Mohd Rashid, Muhammad Hakimi
Abdul Razak, Tariq
Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
description Background: Current evidence indicates mixed findings with regard to the effects of low and high maternal dietary salt intake during pregnancy on the maternal blood pressure. Objective: This study investigates the effects of low and high maternal dietary salt intake on the systolic blood pressure (SBP) at third week of gestation as compared to pre-pregnancy SBP. Methodology: 30 female Sprague Dawley normotensive rats were randomly assigned into three groups based on maternal dietary salt concentration; low salt (0.145% NaCl, n=10), normal salt (1.0% NaCl, n =10) and high salt (3.0% NaCl, n=10). Food intake and maternal body weight were recorded. SBP (mmHg) and heart rate (HR) were measured during pre-pregnancy and at third week of pregnancy by using non-invasive tail cuff blood pressure monitoring device. Results: There were comparable pre-pregnancy body weight, mean daily food intake, HR and SBP (116.5± 1.54 vs. 118.07 ± 1.22 vs. 115.83 ± 1.76) among LSD, NSD and HSD dams respectively. There were no significant differences in maternal mean daily food intake throughout the pregnancy, body weight at third week of gestation, HR and SBP (113.67± 2.74 vs. 111.37 ± 1.84 vs. 113.93 ± 2.11) at third week of gestation among LSD, NSD and HSD dams respectively. Statistically significant difference in term of SBP between pre-pregnancy and third week of gestation was only seen in the NSD dams (118.07 ±1.22 vs. 111.37 ±1.84) (P<0.05). HR was comparable among the three dams. Conclusion: The SBP decreases in all maternal groups at third week of gestation. However, within group analysis revealed that only NSD dams has significantly lower SBP at third week of gestation as compared to pre- pregnancy SBP. The decrement of SBP is more pronounced in the NSD dams depicting the possibilities of aberration in the expected cardiovascular physiological changes in LSD and HSD dams.
format Conference or Workshop Item
author Mohd Noor, Noriah
Aminuddin, Niferiti
Tin, Myo Han
Mohd Rashid, Muhammad Hakimi
Abdul Razak, Tariq
author_facet Mohd Noor, Noriah
Aminuddin, Niferiti
Tin, Myo Han
Mohd Rashid, Muhammad Hakimi
Abdul Razak, Tariq
author_sort Mohd Noor, Noriah
title Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_short Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_full Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_fullStr Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_full_unstemmed Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_sort maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
publishDate 2015
url http://irep.iium.edu.my/45310/1/Noriah_et_al_2015.pdf
http://irep.iium.edu.my/45310/
http://icmh2015.usim.edu.my/
_version_ 1643612764214657024
score 13.211869

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