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Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions

Aim and purpose: To investigate the difference in biological behavior between Giant Cell Lesion in oral cavity with Giant Cells tumors in long bones by using transforming growth factor beta (IHC) marker. Materials and method: Total of 40 cases of giant cell lesions (C.G.C.G., P.G.C.G. and G.C.T) w...

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Main Authors: Abdul Jabbar, Omar, Mustafa Al-Ahmad, Basma Ezzat, Faisal, Ghasak Ghazi
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
RK Dentistry
Online Access:http://irep.iium.edu.my/45156/1/2015-International_Dental_Journal_%28my_abstract_in_page_31%29.pdf
http://irep.iium.edu.my/45156/
http://onlinelibrary.wiley.com/doi/10.1111/idj.12194/abstract
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spelling my.iium.irep.451562016-05-23T03:32:17Z http://irep.iium.edu.my/45156/ Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions Abdul Jabbar, Omar Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi RK Dentistry Aim and purpose: To investigate the difference in biological behavior between Giant Cell Lesion in oral cavity with Giant Cells tumors in long bones by using transforming growth factor beta (IHC) marker. Materials and method: Total of 40 cases of giant cell lesions (C.G.C.G., P.G.C.G. and G.C.T) were included in this study. 17 cases were of G.C.T, 14 of C.G.C.G. and 9 cases were of P.G.C.G. Immunohistochemical staining technique by TGF-b marker was conducted upon these cases showing positive expression in both multinucleated giant cells (MGC) and mononucleated stromal cells (MC) which are considered to be the main histopathological constituent of giant cell lesions.Results: The PGCL showed lightly higher expression of TGF B1 in (MC) than CGCL and GCT but with a non-significant difference value. In comparison of PGCL and CGCL with GCT, they showed higher expression of TGF-b in MGC (p < 0.05). Summary and conclusions: Our results suggest that, in CGCL and PCGL the TGF-b may be important for osteoclastogenesis and bone resorption. 2015 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/45156/1/2015-International_Dental_Journal_%28my_abstract_in_page_31%29.pdf Abdul Jabbar, Omar and Mustafa Al-Ahmad, Basma Ezzat and Faisal, Ghasak Ghazi (2015) Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions. In: FDI 2015 - Annual World Dental Congress, 22-25 Sep 2015, Bangkok. http://onlinelibrary.wiley.com/doi/10.1111/idj.12194/abstract
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RK Dentistry
spellingShingle RK Dentistry
Abdul Jabbar, Omar
Mustafa Al-Ahmad, Basma Ezzat
Faisal, Ghasak Ghazi
Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
description Aim and purpose: To investigate the difference in biological behavior between Giant Cell Lesion in oral cavity with Giant Cells tumors in long bones by using transforming growth factor beta (IHC) marker. Materials and method: Total of 40 cases of giant cell lesions (C.G.C.G., P.G.C.G. and G.C.T) were included in this study. 17 cases were of G.C.T, 14 of C.G.C.G. and 9 cases were of P.G.C.G. Immunohistochemical staining technique by TGF-b marker was conducted upon these cases showing positive expression in both multinucleated giant cells (MGC) and mononucleated stromal cells (MC) which are considered to be the main histopathological constituent of giant cell lesions.Results: The PGCL showed lightly higher expression of TGF B1 in (MC) than CGCL and GCT but with a non-significant difference value. In comparison of PGCL and CGCL with GCT, they showed higher expression of TGF-b in MGC (p < 0.05). Summary and conclusions: Our results suggest that, in CGCL and PCGL the TGF-b may be important for osteoclastogenesis and bone resorption.
format Conference or Workshop Item
author Abdul Jabbar, Omar
Mustafa Al-Ahmad, Basma Ezzat
Faisal, Ghasak Ghazi
author_facet Abdul Jabbar, Omar
Mustafa Al-Ahmad, Basma Ezzat
Faisal, Ghasak Ghazi
author_sort Abdul Jabbar, Omar
title Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_short Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_full Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_fullStr Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_full_unstemmed Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions
title_sort immunoexpression of tgf-b in giant cell tumour, central and peripheral giant cell lesions
publishDate 2015
url http://irep.iium.edu.my/45156/1/2015-International_Dental_Journal_%28my_abstract_in_page_31%29.pdf
http://irep.iium.edu.my/45156/
http://onlinelibrary.wiley.com/doi/10.1111/idj.12194/abstract
_version_ 1643612732606382080
score 13.211869

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