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Diffusion of betamethasone 17-Valerate from palm olein-based vehicle

The current study aims to produce pharmaceutical formulation using palm olein as the oil phase with betamethasone 17-valerate as the active ingredient and to compare efficacy with that of commercial products. Creams were prepared using Span® 20 and Tween® 20 as surfactants, Carbopol® 940 as thickene...

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Main Authors: Win, Thazin, Ahmad, Kausar, Md. Jaffri, Juliana, Edueng, Khadijah
Format: Conference or Workshop Item
Language:English
Published: 2014
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/44989/1/Symposium_CRDDS2014_DiffusionBetamethasone_kausar20151007.pdf
http://irep.iium.edu.my/44989/
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spelling my.iium.irep.449892015-11-19T01:49:53Z http://irep.iium.edu.my/44989/ Diffusion of betamethasone 17-Valerate from palm olein-based vehicle Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah RS Pharmacy and materia medica The current study aims to produce pharmaceutical formulation using palm olein as the oil phase with betamethasone 17-valerate as the active ingredient and to compare efficacy with that of commercial products. Creams were prepared using Span® 20 and Tween® 20 as surfactants, Carbopol® 940 as thickener, methyl paraben, propyl paraben and chlorocresol as preservatives, propylene glycol as solubilizer and distilled water as aqueous phase. The formulations were characterized, subjected to stability studies for 3 months and degradation of betamethasone 17-valerate in the formulations was analysed using HPLC. Evaluation on drug release with three different viscosities was further performed with Hanson Verticle Diffusion Cell System using cellulose acetate and rat skin as membranes and the samples were quantified with HPLC. The results were compared to that of three commmercially available products. The optimized formulation showed particle size ranging from 3 to 14 µm, viscosity 68.2±1.43 mPa.s, yield stress 36.5± 0.2 Pa, thixotropy 647± 58, pH 5.8± 0.1 and zeta potential -51 ± 11 mV. The creams exhibited pseudoplastic behaviour and found to be thixotropic. Less than 5 % of drug is degraded during the 3-month period when subjected to 3 different temperatures. The drug release rates from palm-olein-in-water emulsions were 4.5 times higher than that of commercial products. In conclusion, these findings proved that the creams produced from palm-olein-in-water emulsion could be a superior alternative vehicle for topical drug delivery system. 2014 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/44989/1/Symposium_CRDDS2014_DiffusionBetamethasone_kausar20151007.pdf Win, Thazin and Ahmad, Kausar and Md. Jaffri, Juliana and Edueng, Khadijah (2014) Diffusion of betamethasone 17-Valerate from palm olein-based vehicle. In: CRDDS2014, Controlled Release & Drug Delivery Symposium 2014, 23rd-24th Mar. 2014, DK2 & DK3, Universiti Kebangsaan Malaysia Kuala Lumpur Kampus.
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Win, Thazin
Ahmad, Kausar
Md. Jaffri, Juliana
Edueng, Khadijah
Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
description The current study aims to produce pharmaceutical formulation using palm olein as the oil phase with betamethasone 17-valerate as the active ingredient and to compare efficacy with that of commercial products. Creams were prepared using Span® 20 and Tween® 20 as surfactants, Carbopol® 940 as thickener, methyl paraben, propyl paraben and chlorocresol as preservatives, propylene glycol as solubilizer and distilled water as aqueous phase. The formulations were characterized, subjected to stability studies for 3 months and degradation of betamethasone 17-valerate in the formulations was analysed using HPLC. Evaluation on drug release with three different viscosities was further performed with Hanson Verticle Diffusion Cell System using cellulose acetate and rat skin as membranes and the samples were quantified with HPLC. The results were compared to that of three commmercially available products. The optimized formulation showed particle size ranging from 3 to 14 µm, viscosity 68.2±1.43 mPa.s, yield stress 36.5± 0.2 Pa, thixotropy 647± 58, pH 5.8± 0.1 and zeta potential -51 ± 11 mV. The creams exhibited pseudoplastic behaviour and found to be thixotropic. Less than 5 % of drug is degraded during the 3-month period when subjected to 3 different temperatures. The drug release rates from palm-olein-in-water emulsions were 4.5 times higher than that of commercial products. In conclusion, these findings proved that the creams produced from palm-olein-in-water emulsion could be a superior alternative vehicle for topical drug delivery system.
format Conference or Workshop Item
author Win, Thazin
Ahmad, Kausar
Md. Jaffri, Juliana
Edueng, Khadijah
author_facet Win, Thazin
Ahmad, Kausar
Md. Jaffri, Juliana
Edueng, Khadijah
author_sort Win, Thazin
title Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_short Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_full Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_fullStr Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_full_unstemmed Diffusion of betamethasone 17-Valerate from palm olein-based vehicle
title_sort diffusion of betamethasone 17-valerate from palm olein-based vehicle
publishDate 2014
url http://irep.iium.edu.my/44989/1/Symposium_CRDDS2014_DiffusionBetamethasone_kausar20151007.pdf
http://irep.iium.edu.my/44989/
_version_ 1643612688459235328
score 13.211869

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