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Development of generic gliclazide 60 mg modified release tablets using central composite design

A modified release gliclazide 60 mg tablet using Methocel® K100 Premium LV DC2 as a drug retaining polymer was prepared by direct compression. Central composite design was adopted for formulation optimization. The two independent formulation variables included the amount of Methocel® K100 LV DC2...

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Main Authors: Elsayed, Tarek Mohamed Ali, Mandal, Uttam Kumar, Kasmuri, Abdul Razak
Format: Article
Language:English
Published: College of Pharmacists of Buenos Aires Province, Argentina 2015
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/44848/1/Latin_American_Journal_of_Pharmacy_34_8_page_1516.pdf
http://irep.iium.edu.my/44848/
http://www.latamjpharm.org/
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spelling my.iium.irep.448482017-10-31T11:06:34Z http://irep.iium.edu.my/44848/ Development of generic gliclazide 60 mg modified release tablets using central composite design Elsayed, Tarek Mohamed Ali Mandal, Uttam Kumar Kasmuri, Abdul Razak RS Pharmacy and materia medica A modified release gliclazide 60 mg tablet using Methocel® K100 Premium LV DC2 as a drug retaining polymer was prepared by direct compression. Central composite design was adopted for formulation optimization. The two independent formulation variables included the amount of Methocel® K100 LV DC2 and Maltrin® M150, whereas the response variables were cumulative % drug release in 1, 2, 4, 8, and 12 h. Drug release data were fitted to various mathematical models for describing the release mechanism from tablets. The effect of polymer and maltodextrin content on gliclazide release at different time points were statistically evaluated by applying one-way ANOVA at 0.05. Four more formulas were prepared to evaluate the prediction ability of the model. All the formulations showed a high correlation coefficient (r2) with zero order and Korsmeyer-Peppas release mechanism. The actual cumulative % drug release versus predicted of the evaluation formulations showed good model prediction with high similarity (86-98) and low difference factors (1-3). College of Pharmacists of Buenos Aires Province, Argentina 2015-06-04 Article REM application/pdf en http://irep.iium.edu.my/44848/1/Latin_American_Journal_of_Pharmacy_34_8_page_1516.pdf Elsayed, Tarek Mohamed Ali and Mandal, Uttam Kumar and Kasmuri, Abdul Razak (2015) Development of generic gliclazide 60 mg modified release tablets using central composite design. Latin American Journal of Pharmacy, 34 (8). pp. 1516-1525. ISSN 2362-3853 http://www.latamjpharm.org/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Elsayed, Tarek Mohamed Ali
Mandal, Uttam Kumar
Kasmuri, Abdul Razak
Development of generic gliclazide 60 mg modified release tablets using central composite design
description A modified release gliclazide 60 mg tablet using Methocel® K100 Premium LV DC2 as a drug retaining polymer was prepared by direct compression. Central composite design was adopted for formulation optimization. The two independent formulation variables included the amount of Methocel® K100 LV DC2 and Maltrin® M150, whereas the response variables were cumulative % drug release in 1, 2, 4, 8, and 12 h. Drug release data were fitted to various mathematical models for describing the release mechanism from tablets. The effect of polymer and maltodextrin content on gliclazide release at different time points were statistically evaluated by applying one-way ANOVA at 0.05. Four more formulas were prepared to evaluate the prediction ability of the model. All the formulations showed a high correlation coefficient (r2) with zero order and Korsmeyer-Peppas release mechanism. The actual cumulative % drug release versus predicted of the evaluation formulations showed good model prediction with high similarity (86-98) and low difference factors (1-3).
format Article
author Elsayed, Tarek Mohamed Ali
Mandal, Uttam Kumar
Kasmuri, Abdul Razak
author_facet Elsayed, Tarek Mohamed Ali
Mandal, Uttam Kumar
Kasmuri, Abdul Razak
author_sort Elsayed, Tarek Mohamed Ali
title Development of generic gliclazide 60 mg modified release tablets using central composite design
title_short Development of generic gliclazide 60 mg modified release tablets using central composite design
title_full Development of generic gliclazide 60 mg modified release tablets using central composite design
title_fullStr Development of generic gliclazide 60 mg modified release tablets using central composite design
title_full_unstemmed Development of generic gliclazide 60 mg modified release tablets using central composite design
title_sort development of generic gliclazide 60 mg modified release tablets using central composite design
publisher College of Pharmacists of Buenos Aires Province, Argentina
publishDate 2015
url http://irep.iium.edu.my/44848/1/Latin_American_Journal_of_Pharmacy_34_8_page_1516.pdf
http://irep.iium.edu.my/44848/
http://www.latamjpharm.org/
_version_ 1643612657828233216
score 13.211869

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