Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres
In conventional method, insulin is injected subcutaneously two to four times a day before each meal to maintain the serum glucose level of diabetic patients [1]. This multiple injection routine is complex, painful, inconvenient and fear of hypoglycemia. To improve patient compliance and convenience,...
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my.iium.irep.434982018-05-21T02:29:36Z http://irep.iium.edu.my/43498/ Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza QD Chemistry In conventional method, insulin is injected subcutaneously two to four times a day before each meal to maintain the serum glucose level of diabetic patients [1]. This multiple injection routine is complex, painful, inconvenient and fear of hypoglycemia. To improve patient compliance and convenience, poly(lactide-co-glycolide) (PLGA) based sustained release formulation of insulin delivery has been developed [2]. Generally, the major drawbacks in the development of insulin loaded PLGA microspheres are the high initial burst and incomplete release of encapsulated insulin [3]. Initial burst release means the release of insulin within 24 hours of release studies. Moreover, PLGA microspheres tend to have a very slow or near to zero release of insulin after the initial burst. The slow or no release period is often referred to as the “lag phase” and continues until extensive degradation of PLGA starts. During this period, the patient may not be effectively treated due to the lack of sufficient insulin release [4]. In this study, insulin encapsulated PLGA microspheres have been prepared using a fast degrading hydroxyl terminated–PLGA (PLGA-OH) to reduce the initial burst release and to remove the lag phase with a view to achieve controlled release of insulin. 2015 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/43498/1/43498.pdf Rahman, Md. Mokhlesur and Rezaul Haque, Ansary and Mohamed, Awang and Katas, Haliza (2015) Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres. In: Research Acculturation Collaborative Effort, Colloquim 2015, 13 - 14 January 2015, Barder Enstek, Negeri Sembilan. (Unpublished) http://www.penerbit.upm.my |
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QD Chemistry Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres |
| description |
In conventional method, insulin is injected subcutaneously two to four times a day before each meal to maintain the serum glucose level of diabetic patients [1]. This multiple injection routine is complex, painful, inconvenient and fear of hypoglycemia. To improve patient compliance and convenience, poly(lactide-co-glycolide) (PLGA) based sustained release formulation of insulin delivery has been developed [2]. Generally, the major drawbacks in the development of insulin loaded PLGA microspheres are the high initial burst and incomplete release of encapsulated insulin [3]. Initial burst release means the release of insulin within 24 hours of release studies. Moreover, PLGA microspheres tend to have a very slow or near to zero release of insulin after the initial burst. The slow or no release period is often referred to as the “lag phase” and continues until extensive degradation of PLGA starts. During this period, the patient may not be effectively treated due to the lack of sufficient insulin release [4]. In this study, insulin encapsulated PLGA microspheres have been prepared using a fast degrading hydroxyl terminated–PLGA (PLGA-OH) to reduce the initial burst release and to remove the lag phase with a view to achieve controlled release of insulin. |
| format |
Conference or Workshop Item |
| author |
Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza |
| author_facet |
Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza |
| author_sort |
Rahman, Md. Mokhlesur |
| title |
Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres |
| title_short |
Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres |
| title_full |
Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres |
| title_fullStr |
Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres |
| title_full_unstemmed |
Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres |
| title_sort |
preparation, characterization and reduction of burst release of insulin from biodegradable plga microspheres |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/43498/1/43498.pdf http://irep.iium.edu.my/43498/ http://www.penerbit.upm.my |
| _version_ |
1643612399986540544 |
| score |
13.250345 |