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Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children

Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present stud...

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Main Authors: Kukreja, Ruchi, Saxena, Anil Kumar, Gurtu, Sunil, Ali, Bashir, Sitholey, Prabhat
Format: Article
Language:English
Published: Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2011
Subjects:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
RJ101 Child Health. Child health services
Online Access:http://irep.iium.edu.my/4276/1/ADHD.pdf
http://irep.iium.edu.my/4276/
http://www.e-imj.com/
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spelling my.iium.irep.42762012-01-04T06:47:57Z http://irep.iium.edu.my/4276/ Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children Kukreja, Ruchi Saxena, Anil Kumar Gurtu, Sunil Ali, Bashir Sitholey, Prabhat RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ101 Child Health. Child health services Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present study, salivary antioxidant activity (AOA) in children with ADHD was compared with age-matched normal control subjects, both as a whole and also with regard to the three subtypes. Additionally, the effect of therapy on the altered AOA levels was investigated following short term (<3 months) and long term (1–3 years) treatments. AOA and catalase activities in the saliva were estimated employing previously reported biochemical procedures. Results: While AOA is decreased in ADHD patients as compared to normal subjects, statistically significant decrease is seen only in the combined and the hyperactive-impulsive subtypes. Restoration of AOA and catalase activities is seen only after sustained therapy and not in the short term. Conclusion: It is concluded that ADHD is associated with decrease in AOA and this should possibly also be addressed for limiting the long term outcomes of this condition. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2011-06 Article REM application/pdf en http://irep.iium.edu.my/4276/1/ADHD.pdf Kukreja, Ruchi and Saxena, Anil Kumar and Gurtu, Sunil and Ali, Bashir and Sitholey, Prabhat (2011) Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children. The International Medical Journal Malaysia, 10 (1). pp. 31-35. ISSN 1823-4631 http://www.e-imj.com/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
RJ101 Child Health. Child health services
spellingShingle RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
RJ101 Child Health. Child health services
Kukreja, Ruchi
Saxena, Anil Kumar
Gurtu, Sunil
Ali, Bashir
Sitholey, Prabhat
Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
description Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present study, salivary antioxidant activity (AOA) in children with ADHD was compared with age-matched normal control subjects, both as a whole and also with regard to the three subtypes. Additionally, the effect of therapy on the altered AOA levels was investigated following short term (<3 months) and long term (1–3 years) treatments. AOA and catalase activities in the saliva were estimated employing previously reported biochemical procedures. Results: While AOA is decreased in ADHD patients as compared to normal subjects, statistically significant decrease is seen only in the combined and the hyperactive-impulsive subtypes. Restoration of AOA and catalase activities is seen only after sustained therapy and not in the short term. Conclusion: It is concluded that ADHD is associated with decrease in AOA and this should possibly also be addressed for limiting the long term outcomes of this condition.
format Article
author Kukreja, Ruchi
Saxena, Anil Kumar
Gurtu, Sunil
Ali, Bashir
Sitholey, Prabhat
author_facet Kukreja, Ruchi
Saxena, Anil Kumar
Gurtu, Sunil
Ali, Bashir
Sitholey, Prabhat
author_sort Kukreja, Ruchi
title Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
title_short Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
title_full Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
title_fullStr Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
title_full_unstemmed Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
title_sort antioxidant activity in children with adhd – a comparison in untreated and treated subjects with normal children
publisher Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate 2011
url http://irep.iium.edu.my/4276/1/ADHD.pdf
http://irep.iium.edu.my/4276/
http://www.e-imj.com/
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score 13.211869

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