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Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats

Objectives: To study the effects of Eurycoma Longifolia jack (E.L.) root extract on the serum leptin and testosterone levels of male rats. Methodology: Mature male Albino Wistar rats were used in this study. Serum leptin and testosterone ;levels were analyzed before receiving treatment (control gr...

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Main Authors: Faisal, Ghasak Ghazi, Mustafa Al-Ahmad, Basma Ezzat, Najmuldeen, Ghazi Faisal, Mustafa, Nazih Shaban, Al-Ani, Ali Sabri Radeef, Althunibat, Osama Yousef
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/42547/1/42547.pdf
http://irep.iium.edu.my/42547/
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spelling my.iium.irep.425472018-12-12T04:13:58Z http://irep.iium.edu.my/42547/ Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats Faisal, Ghasak Ghazi Mustafa Al-Ahmad, Basma Ezzat Najmuldeen, Ghazi Faisal Mustafa, Nazih Shaban Al-Ani, Ali Sabri Radeef Althunibat, Osama Yousef RB Pathology Objectives: To study the effects of Eurycoma Longifolia jack (E.L.) root extract on the serum leptin and testosterone levels of male rats. Methodology: Mature male Albino Wistar rats were used in this study. Serum leptin and testosterone ;levels were analyzed before receiving treatment (control group), then the rats were divided into two groups. Group A received 5mg/kg twice daily of pure E.L. root extract. Group B received 10mg/kg twice daily of the same extract. The duration of treatment was 6 weeks for both groups at the end of which, serum leptin and testosterone levels of both groups were analyzed again. Results: The mean serum leptin and testosterone levels for the control group were 1.13ng/ml, 0.79ng/ml. While for group A were1.08ng/ml, 0.98ng/ml and for Group B were 0.89ng/ml,1.75ng/ml respectively. Statistical analysis showed that the serum leptin level of group B was significantly lower than that of control group (p<0.001) and group A(p<0.05). On the other hand, no significant difference in serum leptin levels was observed between the control group and group A. The serum testosterone level was significantly higher in group B than control and group A while group A did not show a statistically significant difference than control. Conclusion: E.L. root extract can significantly decrease serum leptin and increase serum testosterone levels and these effects are dose dependant. 2015 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/42547/1/42547.pdf Faisal, Ghasak Ghazi and Mustafa Al-Ahmad, Basma Ezzat and Najmuldeen, Ghazi Faisal and Mustafa, Nazih Shaban and Al-Ani, Ali Sabri Radeef and Althunibat, Osama Yousef (2015) Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats. In: International Conference on Natural Products 2015, 24-25 March 2015, Double Tree by Hilton, Johor Bahru. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RB Pathology
spellingShingle RB Pathology
Faisal, Ghasak Ghazi
Mustafa Al-Ahmad, Basma Ezzat
Najmuldeen, Ghazi Faisal
Mustafa, Nazih Shaban
Al-Ani, Ali Sabri Radeef
Althunibat, Osama Yousef
Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats
description Objectives: To study the effects of Eurycoma Longifolia jack (E.L.) root extract on the serum leptin and testosterone levels of male rats. Methodology: Mature male Albino Wistar rats were used in this study. Serum leptin and testosterone ;levels were analyzed before receiving treatment (control group), then the rats were divided into two groups. Group A received 5mg/kg twice daily of pure E.L. root extract. Group B received 10mg/kg twice daily of the same extract. The duration of treatment was 6 weeks for both groups at the end of which, serum leptin and testosterone levels of both groups were analyzed again. Results: The mean serum leptin and testosterone levels for the control group were 1.13ng/ml, 0.79ng/ml. While for group A were1.08ng/ml, 0.98ng/ml and for Group B were 0.89ng/ml,1.75ng/ml respectively. Statistical analysis showed that the serum leptin level of group B was significantly lower than that of control group (p<0.001) and group A(p<0.05). On the other hand, no significant difference in serum leptin levels was observed between the control group and group A. The serum testosterone level was significantly higher in group B than control and group A while group A did not show a statistically significant difference than control. Conclusion: E.L. root extract can significantly decrease serum leptin and increase serum testosterone levels and these effects are dose dependant.
format Conference or Workshop Item
author Faisal, Ghasak Ghazi
Mustafa Al-Ahmad, Basma Ezzat
Najmuldeen, Ghazi Faisal
Mustafa, Nazih Shaban
Al-Ani, Ali Sabri Radeef
Althunibat, Osama Yousef
author_facet Faisal, Ghasak Ghazi
Mustafa Al-Ahmad, Basma Ezzat
Najmuldeen, Ghazi Faisal
Mustafa, Nazih Shaban
Al-Ani, Ali Sabri Radeef
Althunibat, Osama Yousef
author_sort Faisal, Ghasak Ghazi
title Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats
title_short Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats
title_full Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats
title_fullStr Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats
title_full_unstemmed Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats
title_sort changes in leptin and testosterone hormones associated with eurycoma longifolia jack (tongkat ali) root extract consumption in male rats
publishDate 2015
url http://irep.iium.edu.my/42547/1/42547.pdf
http://irep.iium.edu.my/42547/
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score 13.211869

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