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Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases

Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging...

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Main Authors: Lestari, Widya, Jaswir, Irwandi, Nordin, Nur Sazwi, Octavianti, Fitri, Nagao, Akihiko
Format: Conference or Workshop Item
Language:English
English
Published: 2014
Subjects:
RK Dentistry
Online Access:http://irep.iium.edu.my/42170/11/42170-certificate.pdf
http://irep.iium.edu.my/42170/13/42170_poster.pdf
http://irep.iium.edu.my/42170/
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spelling my.iium.irep.421702021-06-08T16:19:50Z http://irep.iium.edu.my/42170/ Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko RK Dentistry Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging DNA. Epidemiological evidences have suggested that intake of fruits and vegetables reduces the risk of both cancer and cardiovascular disease. Flavonoids, carotenoids, vitamin C, vitamin E and selenium are the major dietary antioxidants. Several large intervention studies have thus been conducted with beta-carotene and vitamin E, leading investigations on chemoprevention of chronic diseases with dietary antioxidants. However, beta-carotene supplementation has shown not only positive but also negative effects on human health. The antioxidant activity of these compounds may shift into prooxidant activity, depending on the redox potential of the carotenoid molecules as well as on the biological environment in which they act. The prooxidant potency of these compounds is determined by several factors, including oxygen tension, carotenoid concentration, and interactions with other antioxidants. Prooxidant activity can induce harmful results in biologic systems and influence the development of human chronic diseases. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/42170/11/42170-certificate.pdf application/pdf en http://irep.iium.edu.my/42170/13/42170_poster.pdf Lestari, Widya and Jaswir, Irwandi and Nordin, Nur Sazwi and Octavianti, Fitri and Nagao, Akihiko (2014) Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases. In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014), 11th -13th June 2014, Kuala Lumpur. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RK Dentistry
spellingShingle RK Dentistry
Lestari, Widya
Jaswir, Irwandi
Nordin, Nur Sazwi
Octavianti, Fitri
Nagao, Akihiko
Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
description Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging DNA. Epidemiological evidences have suggested that intake of fruits and vegetables reduces the risk of both cancer and cardiovascular disease. Flavonoids, carotenoids, vitamin C, vitamin E and selenium are the major dietary antioxidants. Several large intervention studies have thus been conducted with beta-carotene and vitamin E, leading investigations on chemoprevention of chronic diseases with dietary antioxidants. However, beta-carotene supplementation has shown not only positive but also negative effects on human health. The antioxidant activity of these compounds may shift into prooxidant activity, depending on the redox potential of the carotenoid molecules as well as on the biological environment in which they act. The prooxidant potency of these compounds is determined by several factors, including oxygen tension, carotenoid concentration, and interactions with other antioxidants. Prooxidant activity can induce harmful results in biologic systems and influence the development of human chronic diseases.
format Conference or Workshop Item
author Lestari, Widya
Jaswir, Irwandi
Nordin, Nur Sazwi
Octavianti, Fitri
Nagao, Akihiko
author_facet Lestari, Widya
Jaswir, Irwandi
Nordin, Nur Sazwi
Octavianti, Fitri
Nagao, Akihiko
author_sort Lestari, Widya
title Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_short Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_full Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_fullStr Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_full_unstemmed Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
title_sort dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
publishDate 2014
url http://irep.iium.edu.my/42170/11/42170-certificate.pdf
http://irep.iium.edu.my/42170/13/42170_poster.pdf
http://irep.iium.edu.my/42170/
_version_ 1702169432241995776
score 13.211869

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