Cover Image

Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion

Endotoxins from gram-negative microorganisms initiates clot formation in blood when it is accidentally encountered by horseshoe crab. This property was extensively studied by various researchers as a result Limulus Amebocyte Lysate (LAL) test was established. The LAL tests in general were 3 to 300 t...

Full description

Saved in:
Bibliographic Details
Main Authors: John, Akbar, Khan Chowdhury, Ahmed Jalal, Yunus, Kamaruzzaman, Kasim, Zaleha
Format: Article
Language:English
Published: Asian Network for Scientific Information 2010
Subjects:
QL Zoology
Online Access:http://irep.iium.edu.my/4215/1/1930-1936.pdf
http://irep.iium.edu.my/4215/
http://scialert.net/abstract/?doi=jas.2010.1930.1936
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.4215
record_format dspace
spelling my.iium.irep.42152017-12-07T04:55:08Z http://irep.iium.edu.my/4215/ Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion John, Akbar Khan Chowdhury, Ahmed Jalal Yunus, Kamaruzzaman Kasim, Zaleha QL Zoology Endotoxins from gram-negative microorganisms initiates clot formation in blood when it is accidentally encountered by horseshoe crab. This property was extensively studied by various researchers as a result Limulus Amebocyte Lysate (LAL) test was established. The LAL tests in general were 3 to 300 times more sensitive than the United States Pharmacopeial (USP) rabbit pyrogen test method. It should be noted that major differences among the LAL preparations lie in the area of sensitivity. Differences, up to 100-fold, exist in the sensitivity of the various LAL preparations to the same endotoxin. It is also considerate that the Information on the molecular level interaction between horseshoe crab blood and endotoxin would provide detailed information about the clotting process. Based on the above perspective review of literature was established to elucidate the compounds involved in the clot formation in horseshoe crab blood while encountering with bacterial endotoxin. Since LAL preparation is important for its application in clinical, pharmaceutical, public health and environmental areas, this paper will also discuss some molecular level details in Lysated Amebocyte interaction in clot formation Asian Network for Scientific Information 2010 Article REM application/pdf en http://irep.iium.edu.my/4215/1/1930-1936.pdf John, Akbar and Khan Chowdhury, Ahmed Jalal and Yunus, Kamaruzzaman and Kasim, Zaleha (2010) Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion. Journal of Applied Sciences, 10 (17). pp. 1930-1936. ISSN 1812-5662 (O), 1812-5654 (P) http://scialert.net/abstract/?doi=jas.2010.1930.1936 10.3923/jas.2010.1930.1936
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QL Zoology
spellingShingle QL Zoology
John, Akbar
Khan Chowdhury, Ahmed Jalal
Yunus, Kamaruzzaman
Kasim, Zaleha
Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
description Endotoxins from gram-negative microorganisms initiates clot formation in blood when it is accidentally encountered by horseshoe crab. This property was extensively studied by various researchers as a result Limulus Amebocyte Lysate (LAL) test was established. The LAL tests in general were 3 to 300 times more sensitive than the United States Pharmacopeial (USP) rabbit pyrogen test method. It should be noted that major differences among the LAL preparations lie in the area of sensitivity. Differences, up to 100-fold, exist in the sensitivity of the various LAL preparations to the same endotoxin. It is also considerate that the Information on the molecular level interaction between horseshoe crab blood and endotoxin would provide detailed information about the clotting process. Based on the above perspective review of literature was established to elucidate the compounds involved in the clot formation in horseshoe crab blood while encountering with bacterial endotoxin. Since LAL preparation is important for its application in clinical, pharmaceutical, public health and environmental areas, this paper will also discuss some molecular level details in Lysated Amebocyte interaction in clot formation
format Article
author John, Akbar
Khan Chowdhury, Ahmed Jalal
Yunus, Kamaruzzaman
Kasim, Zaleha
author_facet John, Akbar
Khan Chowdhury, Ahmed Jalal
Yunus, Kamaruzzaman
Kasim, Zaleha
author_sort John, Akbar
title Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_short Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_full Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_fullStr Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_full_unstemmed Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_sort mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
publisher Asian Network for Scientific Information
publishDate 2010
url http://irep.iium.edu.my/4215/1/1930-1936.pdf
http://irep.iium.edu.my/4215/
http://scialert.net/abstract/?doi=jas.2010.1930.1936
_version_ 1643605296224927744
score 13.211869

Similar Items