Acute kidney injury in a Malaysian intensive care unit: assessment of incidence, risk factors and outcome
Purpose Acute Kidney Injury (AKI) is common and carries a high mortality rate. Most epidemiological studies were retrospective and were done in Western populations. We aim to assess its incidence utilising both urine output and creatinine criteria, and its association with risk factors and outcome....
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM)
2015
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| Online Access: | http://irep.iium.edu.my/41224/9/EPI_AKI_PaperJCC.pdf http://irep.iium.edu.my/41224/ http://www.journals.elsevier.com/journal-of-critical-care/ |
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| Summary: | Purpose
Acute Kidney Injury (AKI) is common and carries a high mortality rate. Most epidemiological studies were retrospective and were done in Western populations. We aim to assess its incidence utilising both urine output and creatinine criteria, and its association with risk factors and outcome.
Material and Methods
This was a single centre, prospective observational study. All ICU patients more than 18 years were screened for inclusion in the study. Admission of less than 48 hours, post-elective surgery and ICU readmission were excluded.
Results
A total of 143 patients were recruited, of these, 65% had AKI, of which 18 (19%) were Stage 1, 23 (25%) Stage 2 and 52 (56%) Stage 3. Independent risk factors for AKI includes high APACHE II score and septic shock (OR of 1.20 (1.09 to 1.33) and 8.41 (1.49 to 47.6), respectively). 38% were classified as AKICr, and 61% as AKIuo, and in 34%, both AKICr and AKIuo were present. AKI was an independent risk factor for mortality (HR 2.61 (1.06 to 6.42)).
Conclusions
AKI is common in our ICU, and almost half are highest severity stage. Patients with high severity of illness and septic shock were at risk for AKI. The presence of AKI independently predicted mortality.
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