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Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi

The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia , on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcohol extracts of both leaves and seeds ca...

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Main Authors: Ahmed, Qamar Uddin, Parveen, Nazneen, Khan, N. U., Singhal, K. C.
Format: Article
Language:English
Published: Elsevier Ireland Ltd 2002
Subjects:
QL Zoology
Online Access:http://irep.iium.edu.my/41004/1/Potential_anti%EF%AC%81larial_activity_of_the_leaves_and_seeds_extracts_of_Psoralea_corylifolia.pdf
http://irep.iium.edu.my/41004/
http://www.sciencedirect.com/science/article/pii/S0378874102001411
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spelling my.iium.irep.410042015-03-11T01:41:44Z http://irep.iium.edu.my/41004/ Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi Ahmed, Qamar Uddin Parveen, Nazneen Khan, N. U. Singhal, K. C. QL Zoology The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia , on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcohol extracts of both leaves and seeds caused the inhibition of spontaneous movements of the whole worm and the nerve muscle preparation of S. cervi , characterised by initial, short lasting small increase in tone of contractions followed by paralysis. The initial stimulatory effect was not observed by alcohol extract of leaves on nerve muscle preparation. The concentrations required to inhibit the movements of whole worm and nerve muscle preparations for alcohol extracts of leaves and seeds were 160, 30, and 150, 20 mg/ml, respectively suggesting a cuticular permeability barrier. Alcohol extracts of both leaves and seeds caused death of microfilariae in vitro, LC50 and LC90 being 15 and 25 ng/ml for alcohol extract of leaves and 12 and 18 ng/ml for alcohol extract of seeds,respectively. Elsevier Ireland Ltd 2002-09-01 Article REM application/pdf en http://irep.iium.edu.my/41004/1/Potential_anti%EF%AC%81larial_activity_of_the_leaves_and_seeds_extracts_of_Psoralea_corylifolia.pdf Ahmed, Qamar Uddin and Parveen, Nazneen and Khan, N. U. and Singhal, K. C. (2002) Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi. Journal of Ethnopharmacology, 82 (1). pp. 23-28. ISSN 0378-8741 http://www.sciencedirect.com/science/article/pii/S0378874102001411 10.1016/S0378-8741(02)00141-1
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QL Zoology
spellingShingle QL Zoology
Ahmed, Qamar Uddin
Parveen, Nazneen
Khan, N. U.
Singhal, K. C.
Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
description The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia , on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcohol extracts of both leaves and seeds caused the inhibition of spontaneous movements of the whole worm and the nerve muscle preparation of S. cervi , characterised by initial, short lasting small increase in tone of contractions followed by paralysis. The initial stimulatory effect was not observed by alcohol extract of leaves on nerve muscle preparation. The concentrations required to inhibit the movements of whole worm and nerve muscle preparations for alcohol extracts of leaves and seeds were 160, 30, and 150, 20 mg/ml, respectively suggesting a cuticular permeability barrier. Alcohol extracts of both leaves and seeds caused death of microfilariae in vitro, LC50 and LC90 being 15 and 25 ng/ml for alcohol extract of leaves and 12 and 18 ng/ml for alcohol extract of seeds,respectively.
format Article
author Ahmed, Qamar Uddin
Parveen, Nazneen
Khan, N. U.
Singhal, K. C.
author_facet Ahmed, Qamar Uddin
Parveen, Nazneen
Khan, N. U.
Singhal, K. C.
author_sort Ahmed, Qamar Uddin
title Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_short Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_full Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_fullStr Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_full_unstemmed Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_sort potential antifilarial activity of the leaves and seeds extracts of psoralea corylifolia on cattle filarial parasite setaria cervi
publisher Elsevier Ireland Ltd
publishDate 2002
url http://irep.iium.edu.my/41004/1/Potential_anti%EF%AC%81larial_activity_of_the_leaves_and_seeds_extracts_of_Psoralea_corylifolia.pdf
http://irep.iium.edu.my/41004/
http://www.sciencedirect.com/science/article/pii/S0378874102001411
_version_ 1643611929645678592
score 13.211869

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