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Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects

Purpose. The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young and elderly subjects. Methods. Doppler FD-OCT blood flow w...

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Main Authors: Tayyari, Faryan Tayyari, Yusof, Firdaus, Vymyslicky, Michal, Tan, Ou, Huang, David, Flanagan, John G. Flanagan, Hudson, Christopher
Format: Article
Language:English
English
Published: The Association for Research in Vision and Ophthalmology, Inc. 2014
Subjects:
QC Physics
RE Ophthalmology
Online Access:http://irep.iium.edu.my/40327/1/FYA_variability_IOVS_paper.pdf
http://irep.iium.edu.my/40327/4/40327_Variability%20and%20repeatability%20of%20quantitative_scopus.pdf
http://irep.iium.edu.my/40327/
http://www.iovs.org/content/current
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spelling my.iium.irep.403272017-09-19T02:57:15Z http://irep.iium.edu.my/40327/ Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects Tayyari, Faryan Tayyari Yusof, Firdaus Vymyslicky, Michal Tan, Ou Huang, David Flanagan, John G. Flanagan Hudson, Christopher QC Physics RE Ophthalmology Purpose. The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young and elderly subjects. Methods. Doppler FD-OCT blood flow was measured using the RTVue system. One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ±5.1 years) subjects was randomly selected, and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e., each separate measurement comprising an upper and a lower nasal pupil scan) were acquired at each session. Measurements were repeated approximately 2 weeks later. Total retinal blood flow was calculated by summing flow from all detectable venules surrounding the optic nerve head. The coefficient of variation (COV) and coefficient of repeatability (COR) were calculated for each individual. Results. The individual COVs for retinal blood flow for young subjects ranged from 0.4% to 20.4% (median 7.5%) and for the elderly subjects ranged from 0.6% to 34.6% (median 9.2%). The group mean CORs for retinal blood flow for young participants were 6.4 μL/min (median 5.91 μL/min, relative to a mean effect 39.8 μL/min) and for elderly subjects were 10.5 μL/min (median 9.2 μL/min, relative to a mean effect 46.4 μL/min). Conclusions. Doppler FD-OCT gave consistent and repeatable blood flow measurements within retinal venules in normal subjects. Considering the individual variation in blood flow measurements, confidence limits for retinal hemodynamics need to be determined on an individual basis. The Association for Research in Vision and Ophthalmology, Inc. 2014 Article REM application/pdf en http://irep.iium.edu.my/40327/1/FYA_variability_IOVS_paper.pdf application/pdf en http://irep.iium.edu.my/40327/4/40327_Variability%20and%20repeatability%20of%20quantitative_scopus.pdf Tayyari, Faryan Tayyari and Yusof, Firdaus and Vymyslicky, Michal and Tan, Ou and Huang, David and Flanagan, John G. Flanagan and Hudson, Christopher (2014) Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects. Investigative Ophthalmology & Visual Science, 55 (12). pp. 7716-7725. ISSN 0146-0404 http://www.iovs.org/content/current 10.1167/iovs.14-14430
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QC Physics
RE Ophthalmology
spellingShingle QC Physics
RE Ophthalmology
Tayyari, Faryan Tayyari
Yusof, Firdaus
Vymyslicky, Michal
Tan, Ou
Huang, David
Flanagan, John G. Flanagan
Hudson, Christopher
Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
description Purpose. The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young and elderly subjects. Methods. Doppler FD-OCT blood flow was measured using the RTVue system. One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ±5.1 years) subjects was randomly selected, and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e., each separate measurement comprising an upper and a lower nasal pupil scan) were acquired at each session. Measurements were repeated approximately 2 weeks later. Total retinal blood flow was calculated by summing flow from all detectable venules surrounding the optic nerve head. The coefficient of variation (COV) and coefficient of repeatability (COR) were calculated for each individual. Results. The individual COVs for retinal blood flow for young subjects ranged from 0.4% to 20.4% (median 7.5%) and for the elderly subjects ranged from 0.6% to 34.6% (median 9.2%). The group mean CORs for retinal blood flow for young participants were 6.4 μL/min (median 5.91 μL/min, relative to a mean effect 39.8 μL/min) and for elderly subjects were 10.5 μL/min (median 9.2 μL/min, relative to a mean effect 46.4 μL/min). Conclusions. Doppler FD-OCT gave consistent and repeatable blood flow measurements within retinal venules in normal subjects. Considering the individual variation in blood flow measurements, confidence limits for retinal hemodynamics need to be determined on an individual basis.
format Article
author Tayyari, Faryan Tayyari
Yusof, Firdaus
Vymyslicky, Michal
Tan, Ou
Huang, David
Flanagan, John G. Flanagan
Hudson, Christopher
author_facet Tayyari, Faryan Tayyari
Yusof, Firdaus
Vymyslicky, Michal
Tan, Ou
Huang, David
Flanagan, John G. Flanagan
Hudson, Christopher
author_sort Tayyari, Faryan Tayyari
title Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_short Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_full Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_fullStr Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_full_unstemmed Variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
title_sort variability and repeatability of quantitative, fourier-domain optical coherence tomography doppler blood flow in young and elderly healthy subjects
publisher The Association for Research in Vision and Ophthalmology, Inc.
publishDate 2014
url http://irep.iium.edu.my/40327/1/FYA_variability_IOVS_paper.pdf
http://irep.iium.edu.my/40327/4/40327_Variability%20and%20repeatability%20of%20quantitative_scopus.pdf
http://irep.iium.edu.my/40327/
http://www.iovs.org/content/current
_version_ 1643611799958847488
score 13.211869

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