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Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl

Entada spiralis ridl (lenguminoceae) is a liana or woody climber that grows in the wild in Malaysia and is known locally as "Beluru" or "Sintok". The isolation and characterization of the chemical constituent from an active fraction of E. spiralis stem bark has been carried out....

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Main Authors: Harun, Aiza, Mat So'ad, Siti Zaiton, Mohd Hassan, Norazian, Che Mohd Ramli, Neni Kartini
Format: Conference or Workshop Item
Language:English
English
Published: 2014
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/40051/1/Abstract_RCSTSS2014aiza_2014.pdf
http://irep.iium.edu.my/40051/2/Abstractrcstss2014.pdf
http://irep.iium.edu.my/40051/
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spelling my.iium.irep.400512015-01-06T07:34:26Z http://irep.iium.edu.my/40051/ Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini QD Chemistry Entada spiralis ridl (lenguminoceae) is a liana or woody climber that grows in the wild in Malaysia and is known locally as "Beluru" or "Sintok". The isolation and characterization of the chemical constituent from an active fraction of E. spiralis stem bark has been carried out. Our previous study revealed that methanol extract of E. spiralis stem bark exhibited promising antifungal activity against three dermatophyte strains, namely Trichophyton mentagrophytes ATCC 9533, Trichophyton tonsurans ATCC 28942 and Microsporum Gypseum ATCC 24102 that cause skin infection. This study was performed to elucidate the structure of active constituent known as ester saponin from the active fraction of E. spiralis stem bark. The factions were prepared using fractionation process and repeated antifungel test was conducted to identify the most active fraction. The structure elucidation of this compound was based on spectroscopis data (1H, 13C NMR, HMQC, HMBC and DEPT135) and comparison with literature. on the basis of spectroscopis analysis, the compound was identified as 28-α,L-rhamnopyranosyl-18,21,22-trihydroxy-12-en-29-(2-acetylamino-β-Dglucopyranosyl)triterpene ester. The current study provides important baseline information for the use of E. spiralis for the treatment of skin infection caused by the microorganism investigated in this study. 2014 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/40051/1/Abstract_RCSTSS2014aiza_2014.pdf application/pdf en http://irep.iium.edu.my/40051/2/Abstractrcstss2014.pdf Harun, Aiza and Mat So'ad, Siti Zaiton and Mohd Hassan, Norazian and Che Mohd Ramli, Neni Kartini (2014) Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl. In: Regional Conference On Science, Technology & Social Sciences , 23rd - 25th November 2014, Cameron Highlands, Pahang. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QD Chemistry
spellingShingle QD Chemistry
Harun, Aiza
Mat So'ad, Siti Zaiton
Mohd Hassan, Norazian
Che Mohd Ramli, Neni Kartini
Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
description Entada spiralis ridl (lenguminoceae) is a liana or woody climber that grows in the wild in Malaysia and is known locally as "Beluru" or "Sintok". The isolation and characterization of the chemical constituent from an active fraction of E. spiralis stem bark has been carried out. Our previous study revealed that methanol extract of E. spiralis stem bark exhibited promising antifungal activity against three dermatophyte strains, namely Trichophyton mentagrophytes ATCC 9533, Trichophyton tonsurans ATCC 28942 and Microsporum Gypseum ATCC 24102 that cause skin infection. This study was performed to elucidate the structure of active constituent known as ester saponin from the active fraction of E. spiralis stem bark. The factions were prepared using fractionation process and repeated antifungel test was conducted to identify the most active fraction. The structure elucidation of this compound was based on spectroscopis data (1H, 13C NMR, HMQC, HMBC and DEPT135) and comparison with literature. on the basis of spectroscopis analysis, the compound was identified as 28-α,L-rhamnopyranosyl-18,21,22-trihydroxy-12-en-29-(2-acetylamino-β-Dglucopyranosyl)triterpene ester. The current study provides important baseline information for the use of E. spiralis for the treatment of skin infection caused by the microorganism investigated in this study.
format Conference or Workshop Item
author Harun, Aiza
Mat So'ad, Siti Zaiton
Mohd Hassan, Norazian
Che Mohd Ramli, Neni Kartini
author_facet Harun, Aiza
Mat So'ad, Siti Zaiton
Mohd Hassan, Norazian
Che Mohd Ramli, Neni Kartini
author_sort Harun, Aiza
title Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
title_short Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
title_full Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
title_fullStr Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
title_full_unstemmed Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
title_sort bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
publishDate 2014
url http://irep.iium.edu.my/40051/1/Abstract_RCSTSS2014aiza_2014.pdf
http://irep.iium.edu.my/40051/2/Abstractrcstss2014.pdf
http://irep.iium.edu.my/40051/
_version_ 1643611751135051776
score 13.211869

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