Antimalarial activity of Neopetrosia exigua extract in mice

Objective: To evaluate the antimalarial activity of ethanolic extract of Neopetrosia exigua in ICR mice. The safety of the extracts was also ICR mice by the acute oral toxicity test. Methods: The crude ethanol extract of Neopetrosia exigua (50, 100, 200 and 400 mg/kg) was investigated for its ant...

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Main Authors: Abdillah, Syamsudin, Ahmad, Rahmatul Wahidah, Muzaki, Farid Kamal, Mohd Noor, Noriah
Format: Article
Language:English
Published: Association of Pharmaceutical Innovators 2013
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Online Access:http://irep.iium.edu.my/39965/1/1-s2.0-S0974694313003149-main.pdf
http://irep.iium.edu.my/39965/
http://www.sciencedirect.com/science/article/pii/S0974694313003149
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spelling my.iium.irep.399652014-12-16T03:02:34Z http://irep.iium.edu.my/39965/ Antimalarial activity of Neopetrosia exigua extract in mice Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Muzaki, Farid Kamal Mohd Noor, Noriah RC Internal medicine Objective: To evaluate the antimalarial activity of ethanolic extract of Neopetrosia exigua in ICR mice. The safety of the extracts was also ICR mice by the acute oral toxicity test. Methods: The crude ethanol extract of Neopetrosia exigua (50, 100, 200 and 400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei during early infection. The acute toxicity of the extract was also investigated. At the end of 14 days, mice were sacrificed for histopathology study. Results: The extract of Neopetrosia exigua demonstrated significant ( p <0.05) schizonticidal activity. The acute toxicity test showed that the extract of Neopetrosia exigua is toxicological safe by oral administration. Histopathological study revealed normal architecture of kidney and liver of mice. Association of Pharmaceutical Innovators 2013 Article REM application/pdf en http://irep.iium.edu.my/39965/1/1-s2.0-S0974694313003149-main.pdf Abdillah, Syamsudin and Ahmad, Rahmatul Wahidah and Muzaki, Farid Kamal and Mohd Noor, Noriah (2013) Antimalarial activity of Neopetrosia exigua extract in mice. Journal of Pharmacy Research , 6 (8). pp. 799-803. ISSN 0974-6943 http://www.sciencedirect.com/science/article/pii/S0974694313003149 10.1016/j.jopr.2013.08.001
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
Abdillah, Syamsudin
Ahmad, Rahmatul Wahidah
Muzaki, Farid Kamal
Mohd Noor, Noriah
Antimalarial activity of Neopetrosia exigua extract in mice
description Objective: To evaluate the antimalarial activity of ethanolic extract of Neopetrosia exigua in ICR mice. The safety of the extracts was also ICR mice by the acute oral toxicity test. Methods: The crude ethanol extract of Neopetrosia exigua (50, 100, 200 and 400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei during early infection. The acute toxicity of the extract was also investigated. At the end of 14 days, mice were sacrificed for histopathology study. Results: The extract of Neopetrosia exigua demonstrated significant ( p <0.05) schizonticidal activity. The acute toxicity test showed that the extract of Neopetrosia exigua is toxicological safe by oral administration. Histopathological study revealed normal architecture of kidney and liver of mice.
format Article
author Abdillah, Syamsudin
Ahmad, Rahmatul Wahidah
Muzaki, Farid Kamal
Mohd Noor, Noriah
author_facet Abdillah, Syamsudin
Ahmad, Rahmatul Wahidah
Muzaki, Farid Kamal
Mohd Noor, Noriah
author_sort Abdillah, Syamsudin
title Antimalarial activity of Neopetrosia exigua extract in mice
title_short Antimalarial activity of Neopetrosia exigua extract in mice
title_full Antimalarial activity of Neopetrosia exigua extract in mice
title_fullStr Antimalarial activity of Neopetrosia exigua extract in mice
title_full_unstemmed Antimalarial activity of Neopetrosia exigua extract in mice
title_sort antimalarial activity of neopetrosia exigua extract in mice
publisher Association of Pharmaceutical Innovators
publishDate 2013
url http://irep.iium.edu.my/39965/1/1-s2.0-S0974694313003149-main.pdf
http://irep.iium.edu.my/39965/
http://www.sciencedirect.com/science/article/pii/S0974694313003149
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score 13.211869