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Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion

A number of antihypertensive drugs are known to be diabetogenic. This may contribute to less than expected decrease in the incidence of coronary heart disease with reduction in blood pressure with treatment in hypertensive patients. This study was aimed to determine the effects of a member, Valsarta...

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Main Authors: Ayob, Azizi, Hashim, Suhaimi, Azdan, Zulnizam, Abdul Razak, Tariq
Format: Article
Language:English
Published: Islamic World Academy of Sciences 2006
Subjects:
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/399/1/Medical_Journal_of_Islamic_World_Academy_of_Sciences.pdf
http://irep.iium.edu.my/399/
http://www.medicaljournal-ias.org/tr/Icerik.aspx?IcerikID=124
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spelling my.iium.irep.3992016-11-12T04:50:58Z http://irep.iium.edu.my/399/ Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion Ayob, Azizi Hashim, Suhaimi Azdan, Zulnizam Abdul Razak, Tariq RM Therapeutics. Pharmacology A number of antihypertensive drugs are known to be diabetogenic. This may contribute to less than expected decrease in the incidence of coronary heart disease with reduction in blood pressure with treatment in hypertensive patients. This study was aimed to determine the effects of a member, Valsartan, of a new class of drugs, angiotensin II receptor blocker, on glucose induced insulin secretion. Male albino rat pancreases were used. The isolated ancreases were perfused with Kreb's solution containing bovine albumin (200 mg/dl) with low glucose (60 mg/dl) followed by high glucose (300 mg/dl) at a rate of 4 ml/min. The dose of Valsartan used was based on the peak plasma level achieved in human at standard single oral dose of 80 mg daily, which was 1.64 mg/L. Five treatment groups were used: Control group, Valsartan at 10%, Valsartan at 100% and Valsartan at 10 times of the 1.64 mg/L, and Diazoxide 10 μg/ml group. Insulin levels in the perfusate were measured by radioimmunoassay. Valsartan at all concentrations significantly increases glucose induced insulin secretion (p < 0.05). Valsartan at 10 %, Valsartan at 100% and Valsartan at 10 times of the 16.4 mg/L, increases glucose induced insulin secretion by 226.4 %, 161.7 % and 156.3 %, respectively. Diazoxide, significantly inhibits glucose induced insulin secretion (p < 0.05). Valsartan at all concentrations enhances glucose-induced insulin secretion in isolated rat pancreas technique. Islamic World Academy of Sciences 2006-11 Article REM application/pdf en http://irep.iium.edu.my/399/1/Medical_Journal_of_Islamic_World_Academy_of_Sciences.pdf Ayob, Azizi and Hashim, Suhaimi and Azdan, Zulnizam and Abdul Razak, Tariq (2006) Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion. Medical Journal of Islamic World Academy of Sciences, 16 (1). pp. 11-17. ISSN 1016-3360 http://www.medicaljournal-ias.org/tr/Icerik.aspx?IcerikID=124
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Ayob, Azizi
Hashim, Suhaimi
Azdan, Zulnizam
Abdul Razak, Tariq
Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
description A number of antihypertensive drugs are known to be diabetogenic. This may contribute to less than expected decrease in the incidence of coronary heart disease with reduction in blood pressure with treatment in hypertensive patients. This study was aimed to determine the effects of a member, Valsartan, of a new class of drugs, angiotensin II receptor blocker, on glucose induced insulin secretion. Male albino rat pancreases were used. The isolated ancreases were perfused with Kreb's solution containing bovine albumin (200 mg/dl) with low glucose (60 mg/dl) followed by high glucose (300 mg/dl) at a rate of 4 ml/min. The dose of Valsartan used was based on the peak plasma level achieved in human at standard single oral dose of 80 mg daily, which was 1.64 mg/L. Five treatment groups were used: Control group, Valsartan at 10%, Valsartan at 100% and Valsartan at 10 times of the 1.64 mg/L, and Diazoxide 10 μg/ml group. Insulin levels in the perfusate were measured by radioimmunoassay. Valsartan at all concentrations significantly increases glucose induced insulin secretion (p < 0.05). Valsartan at 10 %, Valsartan at 100% and Valsartan at 10 times of the 16.4 mg/L, increases glucose induced insulin secretion by 226.4 %, 161.7 % and 156.3 %, respectively. Diazoxide, significantly inhibits glucose induced insulin secretion (p < 0.05). Valsartan at all concentrations enhances glucose-induced insulin secretion in isolated rat pancreas technique.
format Article
author Ayob, Azizi
Hashim, Suhaimi
Azdan, Zulnizam
Abdul Razak, Tariq
author_facet Ayob, Azizi
Hashim, Suhaimi
Azdan, Zulnizam
Abdul Razak, Tariq
author_sort Ayob, Azizi
title Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
title_short Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
title_full Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
title_fullStr Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
title_full_unstemmed Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
title_sort angiotensin ii receptor blocker valsartan enhances glucose-induced insulin secretion
publisher Islamic World Academy of Sciences
publishDate 2006
url http://irep.iium.edu.my/399/1/Medical_Journal_of_Islamic_World_Academy_of_Sciences.pdf
http://irep.iium.edu.my/399/
http://www.medicaljournal-ias.org/tr/Icerik.aspx?IcerikID=124
_version_ 1643604605453467648
score 13.211869

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