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Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit

Momordica charantia or bitter melon is widely used as traditional medicine for diabetic patient. This study developed a statistical model in predicting the alpha-glucosidase inhibitory activity of M. charantia fruit based on Fourier Transform Infrared Spectroscopy (FTIR). A total of six different...

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主要な著者: Perumal, Vikneswari, Khatib, Alfi, Uzir, Bisha Fathamah, Abas, Faridah, Bajrai, Aishah, Ahmed, Qamar Uddin, Nik Yusoff, Nik Mohd. Idris
フォーマット: Conference or Workshop Item
言語:English
English
出版事項: 2014
主題:
R Medicine (General)
オンライン･アクセス:http://irep.iium.edu.my/39565/1/IHCI_2014_Programme_Book.pdf
http://irep.iium.edu.my/39565/2/IHCI_2014_Abstract_Book.pdf
http://irep.iium.edu.my/39565/
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spelling my.iium.irep.395652018-05-23T07:00:23Z http://irep.iium.edu.my/39565/ Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit Perumal, Vikneswari Khatib, Alfi Uzir, Bisha Fathamah Abas, Faridah Bajrai, Aishah Ahmed, Qamar Uddin Nik Yusoff, Nik Mohd. Idris R Medicine (General) Momordica charantia or bitter melon is widely used as traditional medicine for diabetic patient. This study developed a statistical model in predicting the alpha-glucosidase inhibitory activity of M. charantia fruit based on Fourier Transform Infrared Spectroscopy (FTIR). A total of six different ethanol extracts (0, 20, 40, 60, 80, and 100%) of this plant were prepared. The chemical profiles of the extracts was conducted using FTIR spectroscopy between 4000 and 600/cm at a resolution of 4/cm. Multivariate Data Analysis (MVDA) was developed by correlating the bioactivity and the third derivative FTIR spectra of each individual extract using Orthogonal Partial Least Square (OPLS). The result revealed that the regression coefficient (R2) between actual and predicted α-glucosidase inhibitory activity was high (>0.80), and the standard error of prediction (SEP) and standard error of estimation (SEE) were acceptable. In conclusion, FTIR spectroscopy is a cheap and high-throughput technique that can be used as to predict the α-glucosidase inhibition activity of M. charantia fruit . 2014-12-03 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/39565/1/IHCI_2014_Programme_Book.pdf application/pdf en http://irep.iium.edu.my/39565/2/IHCI_2014_Abstract_Book.pdf Perumal, Vikneswari and Khatib, Alfi and Uzir, Bisha Fathamah and Abas, Faridah and Bajrai, Aishah and Ahmed, Qamar Uddin and Nik Yusoff, Nik Mohd. Idris (2014) Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit. In: International Health Conference IIUM 2014, 3rd - 4th December 2014, Kuantan, Pahang.
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Perumal, Vikneswari
Khatib, Alfi
Uzir, Bisha Fathamah
Abas, Faridah
Bajrai, Aishah
Ahmed, Qamar Uddin
Nik Yusoff, Nik Mohd. Idris
Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit
description Momordica charantia or bitter melon is widely used as traditional medicine for diabetic patient. This study developed a statistical model in predicting the alpha-glucosidase inhibitory activity of M. charantia fruit based on Fourier Transform Infrared Spectroscopy (FTIR). A total of six different ethanol extracts (0, 20, 40, 60, 80, and 100%) of this plant were prepared. The chemical profiles of the extracts was conducted using FTIR spectroscopy between 4000 and 600/cm at a resolution of 4/cm. Multivariate Data Analysis (MVDA) was developed by correlating the bioactivity and the third derivative FTIR spectra of each individual extract using Orthogonal Partial Least Square (OPLS). The result revealed that the regression coefficient (R2) between actual and predicted α-glucosidase inhibitory activity was high (>0.80), and the standard error of prediction (SEP) and standard error of estimation (SEE) were acceptable. In conclusion, FTIR spectroscopy is a cheap and high-throughput technique that can be used as to predict the α-glucosidase inhibition activity of M. charantia fruit .
format Conference or Workshop Item
author Perumal, Vikneswari
Khatib, Alfi
Uzir, Bisha Fathamah
Abas, Faridah
Bajrai, Aishah
Ahmed, Qamar Uddin
Nik Yusoff, Nik Mohd. Idris
author_facet Perumal, Vikneswari
Khatib, Alfi
Uzir, Bisha Fathamah
Abas, Faridah
Bajrai, Aishah
Ahmed, Qamar Uddin
Nik Yusoff, Nik Mohd. Idris
author_sort Perumal, Vikneswari
title Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit
title_short Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit
title_full Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit
title_fullStr Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit
title_full_unstemmed Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit
title_sort multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit
publishDate 2014
url http://irep.iium.edu.my/39565/1/IHCI_2014_Programme_Book.pdf
http://irep.iium.edu.my/39565/2/IHCI_2014_Abstract_Book.pdf
http://irep.iium.edu.my/39565/
_version_ 1643611660920815616
score 13.251813

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