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Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats

Neurodegenerative conditions continue to affect a large number of people. Despite numerous studies carried out in the last few decades, no effective treatment has been found and current management of neurodegenerative conditions are not effective, marred by side-effects, costly and could only prov...

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Main Authors: Mohd Shafri, Mohd Affendi, Mohamed, Farahidah, Md. Jaffri, Juliana, Ithnin, Hairuszah, Kyu, Kim Min, Mat Jais, Abdul Manan
Format: Conference or Workshop Item
Language:English
Published: 2013
Subjects:
RZ Other systems of medicine
Online Access:http://irep.iium.edu.my/37102/1/p88_mohdshafri.pdf
http://irep.iium.edu.my/37102/
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spelling my.iium.irep.371022022-12-09T02:46:06Z http://irep.iium.edu.my/37102/ Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md. Jaffri, Juliana Ithnin, Hairuszah Kyu, Kim Min Mat Jais, Abdul Manan RZ Other systems of medicine Neurodegenerative conditions continue to affect a large number of people. Despite numerous studies carried out in the last few decades, no effective treatment has been found and current management of neurodegenerative conditions are not effective, marred by side-effects, costly and could only provide symptomatic alleviations. Haruan or Channa striatus, is rich in many important amino acids and fatty acids, which may act as suitable pharmacological modulators to neuron cells as they have potential to cross the blood-brain barrier, have anti-oxidative action and may trigger neurite growth receptor on neuron cell’s surface. In an in vivo experiment using Sprague Dawley rats, the effect of haruan traditional formulation (HTF) on rats’ nose-dipping and rearing behaviours in neuroprotective and neuroregenerative assays was studied using a hole board maze. Two neurodegenerative agents, ketamine and methamphetamine, were given intraperitoneally, 4 four times a day at 2 hour interval at different doses and rats were further classified into a short (1 day) or long exposure (5 days) groups (n=5 per group). It was found that HTF could provide some neuroprotective (p < 0.01 for the nose dip and p < 0.05 for rearing; one way ANOVA with Tukey’s post hoc analysis) and neuroregenerative (p < 0.001 for both nose dip and rearing; one way ANOVA with Tukey’s post hoc analysis) effects on rats’ behaviour for the long exposure to ketamine group and not in other groups. The results suggests that HTF is studied further for its potential neuro-modifying properties, and treatment of neurodegenerative condition must take into account type and nature of degeneration as well as functional and numerical changes of the brain. 2013-08-27 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/37102/1/p88_mohdshafri.pdf Mohd Shafri, Mohd Affendi and Mohamed, Farahidah and Md. Jaffri, Juliana and Ithnin, Hairuszah and Kyu, Kim Min and Mat Jais, Abdul Manan (2013) Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats. In: 9th International Conference on Cognitive Science (ICCS 2013), 27th-30th Aug. 2013, Kuching, Sarawak. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RZ Other systems of medicine
spellingShingle RZ Other systems of medicine
Mohd Shafri, Mohd Affendi
Mohamed, Farahidah
Md. Jaffri, Juliana
Ithnin, Hairuszah
Kyu, Kim Min
Mat Jais, Abdul Manan
Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats
description Neurodegenerative conditions continue to affect a large number of people. Despite numerous studies carried out in the last few decades, no effective treatment has been found and current management of neurodegenerative conditions are not effective, marred by side-effects, costly and could only provide symptomatic alleviations. Haruan or Channa striatus, is rich in many important amino acids and fatty acids, which may act as suitable pharmacological modulators to neuron cells as they have potential to cross the blood-brain barrier, have anti-oxidative action and may trigger neurite growth receptor on neuron cell’s surface. In an in vivo experiment using Sprague Dawley rats, the effect of haruan traditional formulation (HTF) on rats’ nose-dipping and rearing behaviours in neuroprotective and neuroregenerative assays was studied using a hole board maze. Two neurodegenerative agents, ketamine and methamphetamine, were given intraperitoneally, 4 four times a day at 2 hour interval at different doses and rats were further classified into a short (1 day) or long exposure (5 days) groups (n=5 per group). It was found that HTF could provide some neuroprotective (p < 0.01 for the nose dip and p < 0.05 for rearing; one way ANOVA with Tukey’s post hoc analysis) and neuroregenerative (p < 0.001 for both nose dip and rearing; one way ANOVA with Tukey’s post hoc analysis) effects on rats’ behaviour for the long exposure to ketamine group and not in other groups. The results suggests that HTF is studied further for its potential neuro-modifying properties, and treatment of neurodegenerative condition must take into account type and nature of degeneration as well as functional and numerical changes of the brain.
format Conference or Workshop Item
author Mohd Shafri, Mohd Affendi
Mohamed, Farahidah
Md. Jaffri, Juliana
Ithnin, Hairuszah
Kyu, Kim Min
Mat Jais, Abdul Manan
author_facet Mohd Shafri, Mohd Affendi
Mohamed, Farahidah
Md. Jaffri, Juliana
Ithnin, Hairuszah
Kyu, Kim Min
Mat Jais, Abdul Manan
author_sort Mohd Shafri, Mohd Affendi
title Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats
title_short Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats
title_full Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats
title_fullStr Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats
title_full_unstemmed Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats
title_sort assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced sprague dawley rats
publishDate 2013
url http://irep.iium.edu.my/37102/1/p88_mohdshafri.pdf
http://irep.iium.edu.my/37102/
_version_ 1752146269945462784
score 13.211869

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