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Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats

Nigella sativa (NS), more commonly known as ‘’Habbattu Sauda’’, is a plant that is traditionally used to control hypertension. Evidence based studies revealed that NS exerts diuretic and blood pressure lowering effect in spontaneously hypertensive rat. While the volatile oil of NS acts centrally by...

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Main Authors: Mizher, Hussam A., Noor, Noriah Mohd, Azzubaidi, Marwan Saad
Format: Conference or Workshop Item
Language:English
English
English
English
Published: 2014
Subjects:
QP Physiology
R Medicine (General)
RM300 Drugs and their action
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/36627/1/Conf._NATPRO-5_2014.pdf
http://irep.iium.edu.my/36627/3/nutrient_topics_-_1.pdf
http://irep.iium.edu.my/36627/4/Poster_Session_number.pdf
http://irep.iium.edu.my/36627/6/Program_at_a_glance12.pdf
http://irep.iium.edu.my/36627/
http://www.natpro5.psu.ac.th/
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spelling my.iium.irep.366272014-05-15T01:54:17Z http://irep.iium.edu.my/36627/ Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats Mizher, Hussam A. Noor, Noriah Mohd Azzubaidi, Marwan Saad QP Physiology R Medicine (General) RM300 Drugs and their action RS Pharmacy and materia medica Nigella sativa (NS), more commonly known as ‘’Habbattu Sauda’’, is a plant that is traditionally used to control hypertension. Evidence based studies revealed that NS exerts diuretic and blood pressure lowering effect in spontaneously hypertensive rat. While the volatile oil of NS acts centrally by indirect and direct mechanisms to induce cardio-depressant effect in urethane-anaesthetized rats, Thymoquinone (TQ) represents the main active constituent in the volatile oil, which could be the principal substance of the direct mechanism. Objective was to evaluate the hypotensive effect of TQ and its dose-response relationship in normotensive adult rats using the non-invasive tail-cuff technique. To investigate TQ mechanism of action through muscarinic and β adrenergic receptors. Three doses of TQ (2.5, 5 and 10 mg\kg) were used for assessing TQ hypotensive effect in 3 groups of rats (n=5) under sodium pentobarbital anesthesia. TQ was administered intraperitoneally, and mean arterial blood pressure (MAP) was obtained from recording systolic and diastolic pressure readings using the non-invasive tail-cuff technique and the dose-response relationship was obtained. MAP was then measured for other 2 animal groups pretreated either with atropine (P-at) or propranolol (P-pro) followed by 10 mg/kg TQ. This study confirms the dose-related hypotensive effect of TQ. The study showed that the mechanism of TQ-induced hypotension involves at least stimulation of vascular muscarinic receptors, but not β-adrenergic receptors. This study provides an evidence for the traditional use of Nigella sativa for treatment of hypertension. 2014 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/36627/1/Conf._NATPRO-5_2014.pdf application/pdf en http://irep.iium.edu.my/36627/3/nutrient_topics_-_1.pdf application/pdf en http://irep.iium.edu.my/36627/4/Poster_Session_number.pdf application/pdf en http://irep.iium.edu.my/36627/6/Program_at_a_glance12.pdf Mizher, Hussam A. and Noor, Noriah Mohd and Azzubaidi, Marwan Saad (2014) Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats. In: The 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), May 6-8, 2014, Moevenpick Resort & Spa Karon Beach Phuket, Thailand. (Unpublished) http://www.natpro5.psu.ac.th/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
English
topic QP Physiology
R Medicine (General)
RM300 Drugs and their action
RS Pharmacy and materia medica
spellingShingle QP Physiology
R Medicine (General)
RM300 Drugs and their action
RS Pharmacy and materia medica
Mizher, Hussam A.
Noor, Noriah Mohd
Azzubaidi, Marwan Saad
Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
description Nigella sativa (NS), more commonly known as ‘’Habbattu Sauda’’, is a plant that is traditionally used to control hypertension. Evidence based studies revealed that NS exerts diuretic and blood pressure lowering effect in spontaneously hypertensive rat. While the volatile oil of NS acts centrally by indirect and direct mechanisms to induce cardio-depressant effect in urethane-anaesthetized rats, Thymoquinone (TQ) represents the main active constituent in the volatile oil, which could be the principal substance of the direct mechanism. Objective was to evaluate the hypotensive effect of TQ and its dose-response relationship in normotensive adult rats using the non-invasive tail-cuff technique. To investigate TQ mechanism of action through muscarinic and β adrenergic receptors. Three doses of TQ (2.5, 5 and 10 mg\kg) were used for assessing TQ hypotensive effect in 3 groups of rats (n=5) under sodium pentobarbital anesthesia. TQ was administered intraperitoneally, and mean arterial blood pressure (MAP) was obtained from recording systolic and diastolic pressure readings using the non-invasive tail-cuff technique and the dose-response relationship was obtained. MAP was then measured for other 2 animal groups pretreated either with atropine (P-at) or propranolol (P-pro) followed by 10 mg/kg TQ. This study confirms the dose-related hypotensive effect of TQ. The study showed that the mechanism of TQ-induced hypotension involves at least stimulation of vascular muscarinic receptors, but not β-adrenergic receptors. This study provides an evidence for the traditional use of Nigella sativa for treatment of hypertension.
format Conference or Workshop Item
author Mizher, Hussam A.
Noor, Noriah Mohd
Azzubaidi, Marwan Saad
author_facet Mizher, Hussam A.
Noor, Noriah Mohd
Azzubaidi, Marwan Saad
author_sort Mizher, Hussam A.
title Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_short Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_full Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_fullStr Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_full_unstemmed Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_sort receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
publishDate 2014
url http://irep.iium.edu.my/36627/1/Conf._NATPRO-5_2014.pdf
http://irep.iium.edu.my/36627/3/nutrient_topics_-_1.pdf
http://irep.iium.edu.my/36627/4/Poster_Session_number.pdf
http://irep.iium.edu.my/36627/6/Program_at_a_glance12.pdf
http://irep.iium.edu.my/36627/
http://www.natpro5.psu.ac.th/
_version_ 1643611027922747392
score 13.252925

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