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Serum cancer antigen 125 in patients with pleural effusions

We studied the prevalence of raised serum CA125 in patients with pleural effusions and explored factors affecting its level. Sixty four patients with benign effusions and 36 patients with malignant effusions admitted to the University Malaya Medical Centre from May 2001 to January 2002 were included...

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Main Authors: How, Soon Hin, Liam, C K, Ab Rahman, Jamalludin, Chin, S P, Zal, A. B.
Format: Article
Language:English
Published: Malaysian Medical Association 2006
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/3662/1/Serum_Cancer_Antigen_125.pdf
http://irep.iium.edu.my/3662/
http://www.e-mjm.org/2006/v61n5/Serum_Cancer_Antigen_125.pdf
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spelling my.iium.irep.36622016-03-10T06:49:38Z http://irep.iium.edu.my/3662/ Serum cancer antigen 125 in patients with pleural effusions How, Soon Hin Liam, C K Ab Rahman, Jamalludin Chin, S P Zal, A. B. R Medicine (General) We studied the prevalence of raised serum CA125 in patients with pleural effusions and explored factors affecting its level. Sixty four patients with benign effusions and 36 patients with malignant effusions admitted to the University Malaya Medical Centre from May 2001 to January 2002 were included in the study. There were no significant differences in age, gender and ethnicity of the patients with benign and malignant effusions. There was also no difference in the frequency of the side of pleural effusion between the two groups but compared to benign effusions, a higher proportion of malignant effusions was moderate to large in size (66% versus 39%, p = 0.011). Serum CA125 levels were above 35U/dL in 83.3% and 78.1% of patients with malignant and benign effusions, respectively (p = 0.532). All patients with underlying malignancy and 95.3% of patients with benign effusions had pleural fluid CA125 levels above 35U/dL (p = 0.187). The median levels of CA125 were higher in the pleural fluid than in the serum in all aetiological groups. Higher serum CA125 levels were more likely to be found in patients with moderate to large effusions (p = 0.015), malignant effusions (p = 0.001) and in female patients (0.016). Serum CA125 level showed significant correlation with pleural fluid CA125 level (r = 0.532, p < 0.001) but not with pleural fluid total white blood cell count (r = -0.092, p = 0.362), red blood cell count (r = -0.082, p = 0.417) and lactate dehydrogenase level (r = 0.062, p = 0.541). We conclude that serum CA125 is commonly elevated in patients with benign and malignant pleural effusions. Malaysian Medical Association 2006 Article REM application/pdf en http://irep.iium.edu.my/3662/1/Serum_Cancer_Antigen_125.pdf How, Soon Hin and Liam, C K and Ab Rahman, Jamalludin and Chin, S P and Zal, A. B. (2006) Serum cancer antigen 125 in patients with pleural effusions. The Medical Journal of Malaysia, 61 (5). pp. 558-563. ISSN 0300-5283 http://www.e-mjm.org/2006/v61n5/Serum_Cancer_Antigen_125.pdf
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
How, Soon Hin
Liam, C K
Ab Rahman, Jamalludin
Chin, S P
Zal, A. B.
Serum cancer antigen 125 in patients with pleural effusions
description We studied the prevalence of raised serum CA125 in patients with pleural effusions and explored factors affecting its level. Sixty four patients with benign effusions and 36 patients with malignant effusions admitted to the University Malaya Medical Centre from May 2001 to January 2002 were included in the study. There were no significant differences in age, gender and ethnicity of the patients with benign and malignant effusions. There was also no difference in the frequency of the side of pleural effusion between the two groups but compared to benign effusions, a higher proportion of malignant effusions was moderate to large in size (66% versus 39%, p = 0.011). Serum CA125 levels were above 35U/dL in 83.3% and 78.1% of patients with malignant and benign effusions, respectively (p = 0.532). All patients with underlying malignancy and 95.3% of patients with benign effusions had pleural fluid CA125 levels above 35U/dL (p = 0.187). The median levels of CA125 were higher in the pleural fluid than in the serum in all aetiological groups. Higher serum CA125 levels were more likely to be found in patients with moderate to large effusions (p = 0.015), malignant effusions (p = 0.001) and in female patients (0.016). Serum CA125 level showed significant correlation with pleural fluid CA125 level (r = 0.532, p < 0.001) but not with pleural fluid total white blood cell count (r = -0.092, p = 0.362), red blood cell count (r = -0.082, p = 0.417) and lactate dehydrogenase level (r = 0.062, p = 0.541). We conclude that serum CA125 is commonly elevated in patients with benign and malignant pleural effusions.
format Article
author How, Soon Hin
Liam, C K
Ab Rahman, Jamalludin
Chin, S P
Zal, A. B.
author_facet How, Soon Hin
Liam, C K
Ab Rahman, Jamalludin
Chin, S P
Zal, A. B.
author_sort How, Soon Hin
title Serum cancer antigen 125 in patients with pleural effusions
title_short Serum cancer antigen 125 in patients with pleural effusions
title_full Serum cancer antigen 125 in patients with pleural effusions
title_fullStr Serum cancer antigen 125 in patients with pleural effusions
title_full_unstemmed Serum cancer antigen 125 in patients with pleural effusions
title_sort serum cancer antigen 125 in patients with pleural effusions
publisher Malaysian Medical Association
publishDate 2006
url http://irep.iium.edu.my/3662/1/Serum_Cancer_Antigen_125.pdf
http://irep.iium.edu.my/3662/
http://www.e-mjm.org/2006/v61n5/Serum_Cancer_Antigen_125.pdf
_version_ 1643605185917878272
score 13.211869

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