Cover Image

Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition

The healing efficiency of cutaneous wound increases when Se2+ is added to the unripe papaya phosphate buffered saline (PBS) extract. This study investigated protection against oxidative damage in cutaneous wound by using Se2+ or Zn2+ added unripe papaya PBS extract; Induced cutaneous wound on rat we...

Full description

Saved in:
Bibliographic Details
Main Authors: Nafiu, Bidemi Abdulrazaq, Rahman, Mohammad Tariqur
Format: Conference or Workshop Item
Language:English
Published: 2014
Subjects:
Q Science (General)
Online Access:http://irep.iium.edu.my/35982/1/Antioxidant_activity_of_papaya_extract.pdf
http://irep.iium.edu.my/35982/
http://www.ieomrs.com/icfp/cfp.html
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.35982
record_format dspace
spelling my.iium.irep.359822014-03-12T09:14:03Z http://irep.iium.edu.my/35982/ Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition Nafiu, Bidemi Abdulrazaq Rahman, Mohammad Tariqur Q Science (General) The healing efficiency of cutaneous wound increases when Se2+ is added to the unripe papaya phosphate buffered saline (PBS) extract. This study investigated protection against oxidative damage in cutaneous wound by using Se2+ or Zn2+ added unripe papaya PBS extract; Induced cutaneous wound on rat were topically treated twice/day with 20 μL of extract dissolved in deionised water (5 mg/mL) where Se2+ and Zn2+ was separately added at 0.1 μg/mg extract and 100 μM concentrations respectively. Control groups were treated with deionised water (negative) and solcoseryl (positive). The excised wound homogenate at day 4 and 10 post wounding was used to analyse antioxidants enzyme activities (catalase, superoxide dismutase, glutathione peroxidase) and lipid peroxidation. Se2+ added extract significantly (p< 0.05) reduced the wound size as compared to negative and positive controls throughout the observation period and on days 1 and 7 respectively. Positive control and the extract significantly (p< 0.05) reduced wound size on days 1-5 and 7-9 respectively. Se2+ added extract significantly (p< 0.05) increased the enzymes’ activities on day 4 and 10 compared to negative control and day 4 only when compared to positive control. Remaining treatments significantly (p< 0.05) increased activity of catalase on day 4 and 10 and superoxide dismutase on day 4 only when compared to negative control. All treatments significantly (p< 0.05) decreased lipid peroxidation at day 4 and 10 post wounding. Thus, Se2+ added papaya extracts provide increased protection against oxidative damage during wound repair. Keywords: Papaya extract, wound healing, Se, Zn and antioxidant enzymes 2014 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/35982/1/Antioxidant_activity_of_papaya_extract.pdf Nafiu, Bidemi Abdulrazaq and Rahman, Mohammad Tariqur (2014) Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition. In: 1st International Conference on Food Properties (iCFP2014), 24-26 January 2014, Kuala Lumpur, Malaysia. http://www.ieomrs.com/icfp/cfp.html
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Nafiu, Bidemi Abdulrazaq
Rahman, Mohammad Tariqur
Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition
description The healing efficiency of cutaneous wound increases when Se2+ is added to the unripe papaya phosphate buffered saline (PBS) extract. This study investigated protection against oxidative damage in cutaneous wound by using Se2+ or Zn2+ added unripe papaya PBS extract; Induced cutaneous wound on rat were topically treated twice/day with 20 μL of extract dissolved in deionised water (5 mg/mL) where Se2+ and Zn2+ was separately added at 0.1 μg/mg extract and 100 μM concentrations respectively. Control groups were treated with deionised water (negative) and solcoseryl (positive). The excised wound homogenate at day 4 and 10 post wounding was used to analyse antioxidants enzyme activities (catalase, superoxide dismutase, glutathione peroxidase) and lipid peroxidation. Se2+ added extract significantly (p< 0.05) reduced the wound size as compared to negative and positive controls throughout the observation period and on days 1 and 7 respectively. Positive control and the extract significantly (p< 0.05) reduced wound size on days 1-5 and 7-9 respectively. Se2+ added extract significantly (p< 0.05) increased the enzymes’ activities on day 4 and 10 compared to negative control and day 4 only when compared to positive control. Remaining treatments significantly (p< 0.05) increased activity of catalase on day 4 and 10 and superoxide dismutase on day 4 only when compared to negative control. All treatments significantly (p< 0.05) decreased lipid peroxidation at day 4 and 10 post wounding. Thus, Se2+ added papaya extracts provide increased protection against oxidative damage during wound repair. Keywords: Papaya extract, wound healing, Se, Zn and antioxidant enzymes
format Conference or Workshop Item
author Nafiu, Bidemi Abdulrazaq
Rahman, Mohammad Tariqur
author_facet Nafiu, Bidemi Abdulrazaq
Rahman, Mohammad Tariqur
author_sort Nafiu, Bidemi Abdulrazaq
title Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition
title_short Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition
title_full Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition
title_fullStr Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition
title_full_unstemmed Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition
title_sort antioxidant activity of papaya extract during wound healing is enhanced by se2+ addition
publishDate 2014
url http://irep.iium.edu.my/35982/1/Antioxidant_activity_of_papaya_extract.pdf
http://irep.iium.edu.my/35982/
http://www.ieomrs.com/icfp/cfp.html
_version_ 1643610891125522432
score 13.211869

Similar Items