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High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats

Background: An insult during a critical period of fetal development may result in increased risk for development of hypertension. Objective: This study aims at evaluating the effects of high maternal dietary sodium during pregnancy and lactation on their offspring’s blood pressure at 16 weeks upo...

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Main Authors: Aminuddin, Niferiti, Abdul Razak, Tariq, Azzubaidi, Marwan Saad, Tin, Myo Han, Mohd Noor, Noriah
Format: Conference or Workshop Item
Language:English
Published: 2014
Subjects:
QP Physiology
R Medicine (General)
RG Gynecology and obstetrics
RJ101 Child Health. Child health services
Online Access:http://irep.iium.edu.my/34815/1/HIGH_PERINATAL_SODIUM_CHLORIDE_2014_MSH.pdf
http://irep.iium.edu.my/34815/
http://www.msh.my/article.php?aid=367
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spelling my.iium.irep.348152014-12-12T02:39:06Z http://irep.iium.edu.my/34815/ High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats Aminuddin, Niferiti Abdul Razak, Tariq Azzubaidi, Marwan Saad Tin, Myo Han Mohd Noor, Noriah QP Physiology R Medicine (General) RG Gynecology and obstetrics RJ101 Child Health. Child health services Background: An insult during a critical period of fetal development may result in increased risk for development of hypertension. Objective: This study aims at evaluating the effects of high maternal dietary sodium during pregnancy and lactation on their offspring’s blood pressure at 16 weeks upon 1 month of high dietary sodium challenge. Materials and methods: Normotensive female Sprague-Dawley rats were subjected to timed pregnancy. Pregnant rats were randomly divided into two groups and were fed normal-sodium diet (1.0%NaCl)(n=10) or high-sodium diet (3.0%NaCl) (n=10) during pregnancy and four weeks of lactation. The offspring were weaned at 4 weeks old, Thereafter, both groups were fed with NSD (1.0%NaCl) until 12 weeks old and then challenge with 3%NaCl diet for 4 weeks. Blood pressure was measured in the offsprings at 12 and 16 weeks old. Results: At 12 weeks old, the offspring’s systolic blood pressure (SBP) were significantly higher in HSD than NSD dams respectively (138.42mmHg±2.62 vs 127.27mmHg±2.00). Upon high-sodium challenge, at 16 weeks, the offspring’s SBP were significantly higher in HSD than NSD dams (143.04mmHg ±3.09 vs 131.45mmHg ±1.37). The offspring’s SBP of HSD dams were significantly greater at 16 weeks than at 12 weeks old respectively (143.04mmHg±3.09 vs 138.42mmHg±2.62). Similarly, the offspring SBP of NSD dams were significantly greater at 16 weeks than at 12 weeks old respectively (131.45mmHg ±1.37 vs 127.27mmHg ±2.00). No difference in the heart rate and food intake in both groups at 12 and 16 weeks. However, the body weight of the offspring HSD dams at 12 and 16 weeks are significantly different (389.73g±4.65 vs 443.77g±4.46 ). Similarly, the body weight of the offspring NSD dams at 12 and 16 weeks are also significantly different (384.79g±2.28 vs 434.55g±2.99). Conclusions: This suggests that there were no differences in offspring’s SBP response upon chronic high-sodium challenge in both HSD and NSD dams offspring. However, the offspring of HSD dams is at greater risk of developing hypertension than NSD dams. 2014 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/34815/1/HIGH_PERINATAL_SODIUM_CHLORIDE_2014_MSH.pdf Aminuddin, Niferiti and Abdul Razak, Tariq and Azzubaidi, Marwan Saad and Tin, Myo Han and Mohd Noor, Noriah (2014) High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats. In: 11th Annual Scientific Meeting Malaysian Society of Hypertension (MSH 2014), 17th- 19th January 2014, Dhangri La Hotel, Kuala Lumpur. (In Press) http://www.msh.my/article.php?aid=367
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QP Physiology
R Medicine (General)
RG Gynecology and obstetrics
RJ101 Child Health. Child health services
spellingShingle QP Physiology
R Medicine (General)
RG Gynecology and obstetrics
RJ101 Child Health. Child health services
Aminuddin, Niferiti
Abdul Razak, Tariq
Azzubaidi, Marwan Saad
Tin, Myo Han
Mohd Noor, Noriah
High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats
description Background: An insult during a critical period of fetal development may result in increased risk for development of hypertension. Objective: This study aims at evaluating the effects of high maternal dietary sodium during pregnancy and lactation on their offspring’s blood pressure at 16 weeks upon 1 month of high dietary sodium challenge. Materials and methods: Normotensive female Sprague-Dawley rats were subjected to timed pregnancy. Pregnant rats were randomly divided into two groups and were fed normal-sodium diet (1.0%NaCl)(n=10) or high-sodium diet (3.0%NaCl) (n=10) during pregnancy and four weeks of lactation. The offspring were weaned at 4 weeks old, Thereafter, both groups were fed with NSD (1.0%NaCl) until 12 weeks old and then challenge with 3%NaCl diet for 4 weeks. Blood pressure was measured in the offsprings at 12 and 16 weeks old. Results: At 12 weeks old, the offspring’s systolic blood pressure (SBP) were significantly higher in HSD than NSD dams respectively (138.42mmHg±2.62 vs 127.27mmHg±2.00). Upon high-sodium challenge, at 16 weeks, the offspring’s SBP were significantly higher in HSD than NSD dams (143.04mmHg ±3.09 vs 131.45mmHg ±1.37). The offspring’s SBP of HSD dams were significantly greater at 16 weeks than at 12 weeks old respectively (143.04mmHg±3.09 vs 138.42mmHg±2.62). Similarly, the offspring SBP of NSD dams were significantly greater at 16 weeks than at 12 weeks old respectively (131.45mmHg ±1.37 vs 127.27mmHg ±2.00). No difference in the heart rate and food intake in both groups at 12 and 16 weeks. However, the body weight of the offspring HSD dams at 12 and 16 weeks are significantly different (389.73g±4.65 vs 443.77g±4.46 ). Similarly, the body weight of the offspring NSD dams at 12 and 16 weeks are also significantly different (384.79g±2.28 vs 434.55g±2.99). Conclusions: This suggests that there were no differences in offspring’s SBP response upon chronic high-sodium challenge in both HSD and NSD dams offspring. However, the offspring of HSD dams is at greater risk of developing hypertension than NSD dams.
format Conference or Workshop Item
author Aminuddin, Niferiti
Abdul Razak, Tariq
Azzubaidi, Marwan Saad
Tin, Myo Han
Mohd Noor, Noriah
author_facet Aminuddin, Niferiti
Abdul Razak, Tariq
Azzubaidi, Marwan Saad
Tin, Myo Han
Mohd Noor, Noriah
author_sort Aminuddin, Niferiti
title High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats
title_short High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats
title_full High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats
title_fullStr High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats
title_full_unstemmed High perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats
title_sort high perinatal sodium chloride exposure and blood pressure response to chronic high sodium challenge in adult rats
publishDate 2014
url http://irep.iium.edu.my/34815/1/HIGH_PERINATAL_SODIUM_CHLORIDE_2014_MSH.pdf
http://irep.iium.edu.my/34815/
http://www.msh.my/article.php?aid=367
_version_ 1643610687787761664
score 13.211869

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