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Synthesis and characterization of various type of Azines as potential bioactive agents

Five Azines (HMB, ANGDA, HHS, HBrS and EMB) were successfully synthesized and evaluated for their antimicrobial activities against various strains of microbes and cytotoxic activities against human breast adenocarcinoma (MCF-7) and non-small lung carcinoma (H1299) cell lines. All the compounds were...

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Main Authors: How, Fiona Ni Foong, Abdul Malek, Nurfathiah, Solachuddin Jauhari, Arief Ichwan
Format: Conference or Workshop Item
Language:English
Published: 2013
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/34700/1/rp011_ICECB2013-C0023.pdf
http://irep.iium.edu.my/34700/
http://www.ipcbee.com/vol59/009-ICECB2013-C0023.pdf
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spelling my.iium.irep.347002014-02-24T06:16:21Z http://irep.iium.edu.my/34700/ Synthesis and characterization of various type of Azines as potential bioactive agents How, Fiona Ni Foong Abdul Malek, Nurfathiah Solachuddin Jauhari, Arief Ichwan QD Chemistry Five Azines (HMB, ANGDA, HHS, HBrS and EMB) were successfully synthesized and evaluated for their antimicrobial activities against various strains of microbes and cytotoxic activities against human breast adenocarcinoma (MCF-7) and non-small lung carcinoma (H1299) cell lines. All the compounds were characterized with FTIR spectroscopy and further confirmed with single crystal X-Ray diffraction analyses. Screening of antimicrobial activities showed HMB was selectively against K. pneumonia and C. albicans. Cytotoxic activity was evaluated against breast adenocarcinoma, MCF-7 and non-small lung, H1299 cancer cell lines. All of the compounds were active, particularly ANGDA and HMB were tested to be most potent against both MCF-7 and H1299 cell lines. 2013 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/34700/1/rp011_ICECB2013-C0023.pdf How, Fiona Ni Foong and Abdul Malek, Nurfathiah and Solachuddin Jauhari, Arief Ichwan (2013) Synthesis and characterization of various type of Azines as potential bioactive agents. In: 2013 2nd International Conference on Environment, Chemistry and Biology (IPCBEE), 13th - 14th Dec. 2013, Stockholm, Sweden. http://www.ipcbee.com/vol59/009-ICECB2013-C0023.pdf
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
How, Fiona Ni Foong
Abdul Malek, Nurfathiah
Solachuddin Jauhari, Arief Ichwan
Synthesis and characterization of various type of Azines as potential bioactive agents
description Five Azines (HMB, ANGDA, HHS, HBrS and EMB) were successfully synthesized and evaluated for their antimicrobial activities against various strains of microbes and cytotoxic activities against human breast adenocarcinoma (MCF-7) and non-small lung carcinoma (H1299) cell lines. All the compounds were characterized with FTIR spectroscopy and further confirmed with single crystal X-Ray diffraction analyses. Screening of antimicrobial activities showed HMB was selectively against K. pneumonia and C. albicans. Cytotoxic activity was evaluated against breast adenocarcinoma, MCF-7 and non-small lung, H1299 cancer cell lines. All of the compounds were active, particularly ANGDA and HMB were tested to be most potent against both MCF-7 and H1299 cell lines.
format Conference or Workshop Item
author How, Fiona Ni Foong
Abdul Malek, Nurfathiah
Solachuddin Jauhari, Arief Ichwan
author_facet How, Fiona Ni Foong
Abdul Malek, Nurfathiah
Solachuddin Jauhari, Arief Ichwan
author_sort How, Fiona Ni Foong
title Synthesis and characterization of various type of Azines as potential bioactive agents
title_short Synthesis and characterization of various type of Azines as potential bioactive agents
title_full Synthesis and characterization of various type of Azines as potential bioactive agents
title_fullStr Synthesis and characterization of various type of Azines as potential bioactive agents
title_full_unstemmed Synthesis and characterization of various type of Azines as potential bioactive agents
title_sort synthesis and characterization of various type of azines as potential bioactive agents
publishDate 2013
url http://irep.iium.edu.my/34700/1/rp011_ICECB2013-C0023.pdf
http://irep.iium.edu.my/34700/
http://www.ipcbee.com/vol59/009-ICECB2013-C0023.pdf
_version_ 1643610666205970432
score 13.211869

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