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Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats

The antiarthritic effect of water extraction of C. asiatica leaves in the adjuvant-induced arthritis in rats was investigated. Prior to this, the chemical constituents in C. asiatica leaves were determined through phytochemical analysis and were found to contain alkaloids, terpenoid, flavonoid an...

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Main Authors: Hashim, Ridzwan, Md Radai, Wan Syahirah, Althunibat, Osama Yousef, Zulkipli, Farah Hanis
Format: Article
Language:English
Published: Academic Journals 2013
Subjects:
Q Science (General)
Online Access:http://irep.iium.edu.my/34515/1/ANTIARTHRITIC_EFFECTS_OF_WATER_EXTRACTION_OF_Centella_asiatica.pdf
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spelling my.iium.irep.345152014-01-20T04:08:25Z http://irep.iium.edu.my/34515/ Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats Hashim, Ridzwan Md Radai, Wan Syahirah Althunibat, Osama Yousef Zulkipli, Farah Hanis Q Science (General) The antiarthritic effect of water extraction of C. asiatica leaves in the adjuvant-induced arthritis in rats was investigated. Prior to this, the chemical constituents in C. asiatica leaves were determined through phytochemical analysis and were found to contain alkaloids, terpenoid, flavonoid and tannin. Leaves of C. asiatica were subjected to water extraction by using blender, filtrated and then freeze-dried to produce dried powder. C. asiatica extracts (CAE) as well as the positive control, dexamethasone showed significant effects when applied to establish adjuvant arthritis. Foot volume of rats was measured by using water displacement method known as plethysmography. Intraperitoneal (i.p) administration of CAE for doses 30 mg/kg and 300 mg/kg b.w. reduced the arthritic edema in the ipsilateral paw of rats with maximal inhibition 54.19 ± 6.43% and 41.05 ± 3.41%, respectively. CAE (doses 30 and 300 mg/kg i.p) was able to prevent the spread of the edema from the ipsilateral to the contralateral paws, which indicated the systemic inhibition. Similar results were observed using steroidal anti-inflammatory agent, dexamethasone (1 mg/kg b.w. i.p). Thus, the findings suggests that the water extract of leaves C. asiatica exerted an antiarthritic activity. Academic Journals 2013-11 Article REM application/pdf en http://irep.iium.edu.my/34515/1/ANTIARTHRITIC_EFFECTS_OF_WATER_EXTRACTION_OF_Centella_asiatica.pdf Hashim, Ridzwan and Md Radai, Wan Syahirah and Althunibat, Osama Yousef and Zulkipli, Farah Hanis (2013) Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats. International Journal of Recent Scientific Research , 4 (11). pp. 1701-1705. ISSN 0976-3031 http://www.recentscientific.com
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Hashim, Ridzwan
Md Radai, Wan Syahirah
Althunibat, Osama Yousef
Zulkipli, Farah Hanis
Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats
description The antiarthritic effect of water extraction of C. asiatica leaves in the adjuvant-induced arthritis in rats was investigated. Prior to this, the chemical constituents in C. asiatica leaves were determined through phytochemical analysis and were found to contain alkaloids, terpenoid, flavonoid and tannin. Leaves of C. asiatica were subjected to water extraction by using blender, filtrated and then freeze-dried to produce dried powder. C. asiatica extracts (CAE) as well as the positive control, dexamethasone showed significant effects when applied to establish adjuvant arthritis. Foot volume of rats was measured by using water displacement method known as plethysmography. Intraperitoneal (i.p) administration of CAE for doses 30 mg/kg and 300 mg/kg b.w. reduced the arthritic edema in the ipsilateral paw of rats with maximal inhibition 54.19 ± 6.43% and 41.05 ± 3.41%, respectively. CAE (doses 30 and 300 mg/kg i.p) was able to prevent the spread of the edema from the ipsilateral to the contralateral paws, which indicated the systemic inhibition. Similar results were observed using steroidal anti-inflammatory agent, dexamethasone (1 mg/kg b.w. i.p). Thus, the findings suggests that the water extract of leaves C. asiatica exerted an antiarthritic activity.
format Article
author Hashim, Ridzwan
Md Radai, Wan Syahirah
Althunibat, Osama Yousef
Zulkipli, Farah Hanis
author_facet Hashim, Ridzwan
Md Radai, Wan Syahirah
Althunibat, Osama Yousef
Zulkipli, Farah Hanis
author_sort Hashim, Ridzwan
title Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats
title_short Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats
title_full Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats
title_fullStr Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats
title_full_unstemmed Antiarthritic effects of water extraction of Centella asiatica L. leaves on adjuvant-induced arthritis in rats
title_sort antiarthritic effects of water extraction of centella asiatica l. leaves on adjuvant-induced arthritis in rats
publisher Academic Journals
publishDate 2013
url http://irep.iium.edu.my/34515/1/ANTIARTHRITIC_EFFECTS_OF_WATER_EXTRACTION_OF_Centella_asiatica.pdf
http://irep.iium.edu.my/34515/
http://www.recentscientific.com
_version_ 1643610642539610112
score 13.211869

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