Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is fo...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academic Journals
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/31142/1/JMPR_2013.pdf http://irep.iium.edu.my/31142/ http://www.academicjournals.org/JMPR/abstracts/abstracts/abstracts2013/25May/Ghalib%20et%20al.htm |
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| Summary: | 3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus
falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed
that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that
eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis. The study suggests that the
anti-proliferative property of eupalitin towards the human colorectal tumor cells may be probably due to
its capability to induce apoptosis in cells. |
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