Alcohol consumption and its effect on testicular structure and on sperm count and motility in parent mice and their offspring
Introduction: The goal of the present study was to examine the effect of alcohol consumption on sperm count and motility and the morphological changes in the seminiferous tubules of parent mice and their offspring. Methods: Animals were divided into two groups, Group 1 (alcohol group) of twelve ma...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Islamic University Malaysia
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/30485/1/Alcohol_Consumption_and_Its_Effect_on_Testicular.pdf http://irep.iium.edu.my/30485/ |
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| Summary: | Introduction: The goal of the present study was to examine the effect of alcohol consumption on sperm count
and motility and the morphological changes in the seminiferous tubules of parent mice and their offspring.
Methods: Animals were divided into two groups, Group 1 (alcohol group) of twelve male and twelve female
mice, were given a daily dose of (3 g/kg body weight as 25%, v/v) ethanol by gastric gavage for four and eight
weeks. Group 2 (control group) also of twelve male and twelve female mice; received normal access of food
and water. After four weeks of treatment, the males and females in each group were allowed to mate, and
ethanol treatment continued for up to another four weeks. Twelve male offspring from group 1 and twelve male
offspring from group 2 were selected randomly and allowed to become mature. Male parent mice were killed at
the 4
th
and 8
weeks of treatment, and their male offsprings were killed when they reached maturity age. Results:
Physiological examination of the sperm solution showed that there was a significant decrease in sperm count
and motility after 4 and 8 weeks of ethanol treatment in parent male mice, but this decrease was not significant
in their adult offspring. Furthermore, histological investigations indicated testicular lesions in the parent male
mice and their adult male offspring. Conclusion: Alcohol abuse has deleterious effects on the testes structure
and on the sperm count and motility of the epididymal spermatozoa of both parent mice and their offspring. |
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