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Vaccination: potential adverse effects and future challenges

Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related research, we have analyzed the possible changes in homeostasis of the haematopoieti...

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Main Authors: Aziz, Jazli, Rahman, Mohammad Tariqur
Format: Article
Language:English
Published: Kulliyyah of Science, IIUM 2011
Subjects:
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/29726/1/Vaccination.pdf
http://irep.iium.edu.my/29726/
http://www.iium.edu.my/revival/index.php/revival/article/view/28
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spelling my.iium.irep.297262013-07-31T01:26:05Z http://irep.iium.edu.my/29726/ Vaccination: potential adverse effects and future challenges Aziz, Jazli Rahman, Mohammad Tariqur RM Therapeutics. Pharmacology Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related research, we have analyzed the possible changes in homeostasis of the haematopoietic system in terms of level of antibody (Ab) after vaccination. Several vaccines were reported to increase a wide range of total Ab concentration such as <0.01%-2.40% in children and 0.02%-1.65% in adults. Reported increased level of IgG against Haemophilus influenza type-B was recorded as 605-1210 folds higher in children and 1226-2453 folds higher in adults than the required protective levels. Similar changes were also observed for other vaccines. Such increased level of total Abs at least theoretically can contribute to higher concentration of protein i.e., hyperproteinemia in blood. Since Ab is a polymer of amino acids; therefore hyperproteinemia due to increased level of Ab may in turn affect pH and osmosis of the blood. Therefore, an optimum dose of vaccine(s) for sufficient boost of immune mechanisms, rather than a dose required for highest efficiency, is recommended before an individual is vaccinated. Kulliyyah of Science, IIUM 2011 Article REM application/pdf en http://irep.iium.edu.my/29726/1/Vaccination.pdf Aziz, Jazli and Rahman, Mohammad Tariqur (2011) Vaccination: potential adverse effects and future challenges. Revelation and Science, 1 (2). pp. 25-33. ISSN 2229-9947 http://www.iium.edu.my/revival/index.php/revival/article/view/28
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Aziz, Jazli
Rahman, Mohammad Tariqur
Vaccination: potential adverse effects and future challenges
description Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related research, we have analyzed the possible changes in homeostasis of the haematopoietic system in terms of level of antibody (Ab) after vaccination. Several vaccines were reported to increase a wide range of total Ab concentration such as <0.01%-2.40% in children and 0.02%-1.65% in adults. Reported increased level of IgG against Haemophilus influenza type-B was recorded as 605-1210 folds higher in children and 1226-2453 folds higher in adults than the required protective levels. Similar changes were also observed for other vaccines. Such increased level of total Abs at least theoretically can contribute to higher concentration of protein i.e., hyperproteinemia in blood. Since Ab is a polymer of amino acids; therefore hyperproteinemia due to increased level of Ab may in turn affect pH and osmosis of the blood. Therefore, an optimum dose of vaccine(s) for sufficient boost of immune mechanisms, rather than a dose required for highest efficiency, is recommended before an individual is vaccinated.
format Article
author Aziz, Jazli
Rahman, Mohammad Tariqur
author_facet Aziz, Jazli
Rahman, Mohammad Tariqur
author_sort Aziz, Jazli
title Vaccination: potential adverse effects and future challenges
title_short Vaccination: potential adverse effects and future challenges
title_full Vaccination: potential adverse effects and future challenges
title_fullStr Vaccination: potential adverse effects and future challenges
title_full_unstemmed Vaccination: potential adverse effects and future challenges
title_sort vaccination: potential adverse effects and future challenges
publisher Kulliyyah of Science, IIUM
publishDate 2011
url http://irep.iium.edu.my/29726/1/Vaccination.pdf
http://irep.iium.edu.my/29726/
http://www.iium.edu.my/revival/index.php/revival/article/view/28
_version_ 1643609747149029376
score 13.211869

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